1. 1 One-Minute NMR History Current Events 17 August 2006 Presented by Tim Peck & Dean Olson

2. 2 e-Seminar Etiquette Press *6 to mute Press #6 to un-mute (to ask a question) As a courtesy to others, please mute your phone line while listening:

3. 3 One-Minute NMR historical roots UIUC Campus Paul Lauterbur: MRI Herb Gutowski Memorial

4. 4 One-Minute NMR 2006 tour Am. Soc. of Pharmacognosy: Arlington, VA 8/6 – 8/9 ENC: Monterey, CA 4/24 – 4/28

5. 5 MicroFlow NMR The NMR Front End for the Modern Analytical Laboratory

6. 6 Live Participation Enter Your Sample Info

7. 7 System Operation Watch the Analysis!

8. 8 NMR Data Collected Pre-Conference Varian Inova 600 MHz

9. 9 View the Results! Automated Structure Confirmation Click … Thumbs Up! (Confirmation) Thumbs Down! (Rejection)

10. 10 View the Results! Automated Structure Confirmation Integrated ACD/Web Librarian

11. 11 Am. Soc. Pharmacognosy August 6-9, 2006

12. 12 Natural Products Chemical AssignmentRapid Dereplication M. Gronquist, J. Meinwald, F. C. Schroeder, JACS 2005, 127, pp. 10810-10811 dqf-COSY HMQC HMBC NOESY S. Van der Sar, J. Blunt, and M. Munro, Org. Let. 2006, 8(10), pp. 2059-2061

13. 13 Some time for fun…

14. 14 And re-connecting with old friends

15. 15 How Small is 10 μL?

16. 16 Autosampler Injection Port

17. 17 Autosampler Needle on a 96-Well Microtitre Plate

18. 18 Needle at Wash Station

19. 19 Autosampler Control Pad

20. 20 Solvent Conditioner Bottles

21. 21 Solvent Conditioner

22. 22 One-Minute NMR Features Sample Return Sample Return Stacked Sample Drawers

23. 23 One-Minute NMR System Configuration

24. 24

25. 25 Quiz Question: What is this?

26. 26 Hint: Am. Soc. Pharmacognosy Dinner Cruise was down the Potomac river