1. BLOOD CHAPTER 10

2. FUNCTIONS OF BLOOD BLOOD is in charge of homeostasis in 3 ways 1.BY TRANSPORTATION- -deliver nutrients, oxygen and hormones to cells -carry away waste, carbon dioxide, nitrogen substances (urea and uric acid) and the secretions of the cells

3. FUNCTIONS OF BLOOD 2.BY PROTECTION- - fights off harmful substances with white blood cells via phagocytosis and antibodies -protects against fluid loss- (clotting mechanism) 3.BY REGULATION -regulates acid-base balance -regulates body temperature

4. PROPERTIES OF BLOOD- COLOR- HEMOGLOBIN (the protein pigment in red blood cells) causes it to be red- contains the element IRON. Oxygen binds to the hemoglobin causing a bright crimson-red color. When blood has low oxygen levels blood appears dark-red with a slightly bluish tinge. - This is the color of our veins seen through the skin. We do not have BLUE or GREEN blood

5. PROPERTIES OF BLOOD- VOLUME-typically 8% of our body weight Typical male has 5-6 liters Typical female has 4-5 liters

6. PROPERTIES OF BLOOD- VISCOSITY- (resistance to flow) flows 5 times more slowly than water because blood is thicker, denser and more sticky than water

7. PROPERTIES OF BLOOD- pH- between 7.35 and 7.45-buffer system in place to keep narrow pH range Too much acid (6.0) would lead to ACIDOSIS- where the body cells stop functioning ALKALOSIS- or too little acid also occurs but is rare

8. PARTS OF BLOOD PLASMA- (55%) liquid portion of blood -92% water and 8% solutes (which are mainly proteins but can also be nutrients, electrolytes, and hormones) PLASMA PROTEINS- produced by the liver 1. ALBUMIN- 55%- thickens blood- increases osmotic pressure, Ph buffer 2. GLOBULIN- 38% - antibodies in the immune system 3. FIBRINOGEN-7%- precursor to protein fibrin used for blood clotting

9. ERYTHROCYTES

10. PARTS OF BLOOD FORMED ELEMENTS RED BLOOD CELLS- (45%) ERYTHROCYTES COUNT – called a HEMATOCRIT-4-6 million per cubic millimeter FUNCTION- carry oxygen to cells from lungs STRUCTURE--biconcave discs -no nucleus (anucleate) and no organelles - 120 DAY lifespan- phagocytized by WBC -HEMOGLOBIN- iron containing protein that transports oxygen (occupies 1/3 volume of the RBC)

11. ERYTHROCYTES DISORDERS- ANEMIA- lower than normal oxygen due to lack of RBC or abnormal hemoglobin SICKLE CELL ANEMIA- IRON DEFICIENCY ANEMIA

12. PARTS OF BLOOD WHITE BLOOD CELLS-LEUKOCYTES- COUNT-4,000- 11,000 per cubic millimeter (less than 1% of total volume) STRUCTURE-contain a nucleus and can change shape to travel outside the circulatory system FUNCTION -control diseases

13. LEUKOCYTES- 3 TYPES OF WBC- 1.GRANULOCYTES- cytoplasm contains granules that stain 2.AGRANULOCYTES- no granules in cytoplasm 3.PLATELETS- cell fragments of various shapes

14. White Blood Cells

15. GRANULOCYTES-(312) 1. NEUTROPHILS- (stain pink) phagocytes at infection site- (make up 40- 70% of WBC) 2. EOSINOPHILS-(stain red) phagocytes of parasitic worms, might help w/ allergies (make up 1-4% of WBC) 3. BASOPHILS-(stain blue) discharges histamine which allows blood to release from blood vessels-(swelling) (less than 1%)

16. AGRANULOCYTES 1.LYMPHOCYTES- B lymphocytes- produce antibodies T lymphocytes- help recognize previous infections- involved in graft rejection 2. MONOCYTES - phagocytize and clean up tissue

17. AGRANULOCYTES PLATELETS- involved in blood clotting

18. BLOOD TYPING ANTIGENS - surface proteins on the plasma membrane of red blood cells. These are genetically determined. ANTIBODIES (AGGLUTININS) - proteins in the plasma that will react with the antigens and cause the blood to clump. These proteins are automatically formed early in life.

19. ABO SYSTEM- ANTIGENSANTIBODIES A BLOOD A antibody to B B BLOODBantibody to A AB BLOODA and B NO ANTIBODIES O BLOODNO ANTIGENS antibody to A and B

20. DONORS AND RECEIVERS BLOOD TYPE DONATE TO RECEIVE FROM AA, ABA,O BB, ABB,O ABAB UNIVERSAL RECIPIENT O UNIVERSAL DONOR O

21. Rh BLOOD TYPING SYSTEM Rh POSITIVE- have Rh antigens (most people born this way) Rh NEGATIVEno Rh antigens Antibodies for Rh antigens are not formed until a person has become sensitized. (example- a blood transfusion of an Rh negative person with Rh positive blood, a Rh negative mother delivering an Rh positive child) The is no reaction to the first exposure but from then on after agglutination of the blood will occur.

22. Blood Clotting 3 stages needed to prevent blood loss 1. Platelet plug stage 2. Vascular spasm 3. Coagulation

23. Platelet plug stage Platelets which are repelled by endothelium (inner layer of blood vessel) are attracted to underlying collagen fibers. Platelets also release chemicals to attract more platelets to injury site. Eventually enough platelets pile up to form a PLATELET PLUG

24. VASCULAR SPASMS Platelet plug releases chemical (serotonin) that causes the blood vessel to go into spasms and narrow.

25. COAGULATION Chemicals are released which convert some plasma proteins to THROMBIN with binds with FIBRINOGEN PROTEINS in plasma to create a long hairlike fiber FIBRIN which will form a mesh to catch red blood cells

26. Clotting problems HEMOPHILIA- “bleeder’s disease”- can be caused by lack of any the clotting factors THROMBUS- blood clot in a healthy blood vessel that may travel (called an EMBOLUS) to heart or brain

27. HEMATOPOIESIS- blood cell formation Red blood cells (WBC and platelets) are formed in the red bone marrow found in spongy bone. Red blood cells are formed with nuclei then as they mature (3 to 5 days) the produce huge amounts of hemoglobin which eventually pushes the nucleus and organelles out of the cell.

28. HEMOGLOBIN Each red blood cell contains about 250 Million hemoglobin molecules. Each hemoglobin molecule can carry bind to 4 molecules of oxygen. EACH RED BLOOD CELL can carry 1 BILLION MOLECULES OF OXYGEN

29. KIDNEYS responsibility in HEMATOPOIESIS When blood oxygen levels drop then kidneys produce a hormone called ERYTHROPOIETIN that targets the red bone marrow for production of RBC.

30. How much blood can we lose? Clots usually form in 3 to 6 minutes to stop bleeding 30% of blood volume lost will cause severe shock. Blood banks can store blood for up to 35 days.