1. Clinical features and co-morbidities in dementia due to Alzheimer’s disease
Author : Gyero Reka
Coordinator : Prof. Dr. Gabos Grecu Iosif
Co-authors : Barmou Amani Diana, Georgescu Ion Mihai,
Julia Magyar, Zoltan Kovacs

2. “Memory is all we are. Moments and feelings, captured in amber, strung on filaments of reason. Take a man’s memories and you take all of him. Chip away a memory at a time and you destroy him as surely as if you hammered nail after nail through his skull.”  Mark Lawrence

3. Introduction of dementia due to Alzheimer’s disease (AD)
Alzheimer’s disease is the prototype of a cortical degenerative disease
AD is characterized pathologically by generalized atrophy of the cerebral cortex , neurofibrillary tangles, neuritic (amyloid ) plaques and granulovacuolar degeneration.
A study made in 2006 estimated that 0.40% of the world population (range million, absolute number 26.6 million) were afflicted by AD
Same study predicted that this prevalence would triple and the absolute number would quadruple by 2050

4. What is dementia?
An acquired syndrome of decline in memory and other cognitive functions suffcient to affect daily life in an alert patient
Progressive and disabling
NOT an inherent aspect of aging
Different from normal cognitive lapses

5. Orientative differentiation between normal lapses and dementia
Not recognizing family members
Substituting inappropriate words
Getting lost in own neighborhood
Not recognizing numbers
Rapid mood swings for no reason
Sudden, dramatic personality change
Forgetting a name
Finding right word
Forgetting date or day
Losing objects (keys, glasses)
Gradual changes with aging

6. Factors infulencing onset and progression of AD dementia
Protective factors
Risk factors
Age
Family history
Head injury
Educational background
Estrogen replacement therapy after menopause
NSAIDs
Antioxidants

7. Alzheimer’s Disease Progresses Through Distinct Stages
Mild
Memory loss
Language problems
Mood swings
Personality changes
Diminished judgment
Moderate
Behavioral, personality changes
Unable to learn/recall new info
Long-term memory affected
Wandering, agitation, agression, confusion
Require assistence in activities of daily living
Severe
Gait. Incontinence, motor disturbances
Bedridden
Unable to perform activites of daily living
Placement in long-term care needed
Symptoms

8. Method and subjects Method and subjects Method of study
Retrospective cohort study
Subjects
228 patients hospitalized in 2013
146 (64.03 %) female
82 (35.96 %) male
Average age of 82 years

9. Associated general medical conditions classified in system pathologies
Cardiovascular diseases

10. Associated general medical conditions classified in system pathologies

11. Associated general medical conditions classified in system pathologies

12. Associated general medical conditions classified in system pathologies

13. Associated general medical conditions classified in system pathologies

14. Associated general medical conditions classified in system pathologies

15. Associated general medical conditions classified in system pathologies

16. Associated general medical conditions classified in system pathologies

17. Psychopathologic findings

18. Psychopathologic findings

19. Psychopathologic findings

20. Psychopathologic findings

21. Conclusion
Dementias due to Alzheimer’s disease are pathologies affecting women and men in a ratio of 1.8:1
Majority of patients are diagnozed after the age of 65 years
3 most common underlying general medical conditions are: artherial hypertension, type II diabetes and chronic ischemic cardiomyopathy
Clinical sympotms such as cognitive impairment, loss of memory, apraxia, aphasia, decline in self-care and so on are sever enough to interfere with the patient’s daily living

22. Thank you for your anticipated support !