1. 1 Texas A&M One Health Grand Challenge Overview & Proposal Process November 26, 2013

2. What are the Grand Challenges?  One Health – human health, animal health and the connections between health and natural & man-made environments  Energy – power the future of our nation & world  Democracy – achieve a secure nation and safer world  Entrepreneurship – create opportunities in US & globally  STEM Education – promote educational achievements for all  Natural and Built Environments – ensuring a sustainable society 2

3. The collaborative effort of multiple disciplines working locally, nationally, and globally to attain sustainable optimal health for the ecosystem* What is One Health? Human Health Animal Health Connection between health and natural & man-made environments ONE HEALTH * a biological community of living organisms (humans, animals, plants, and microbes) and their physical environment interacting as a system

4. Agriculture & Life Sciences Nursing Veterinary Medicine & Biomedical Science Geosciences Education & Human Development Science Animal Health Human Health Engineering Medicine Dentistry Architecture Pharmacy Library Rural Public Health Bush School Law Business School Liberal Arts TAMU at Galveston Connection between health and natural & man-made environments

5. Research Criteria  One Health related (human health, animal health and the connections between health and natural & man-made environments)  High socioeconomic impact on state/national/global scale, that would attract funding - public, private, not-for-profit (“transformative”)  Leverage TAMU strengths in multiple colleges and university entities (“transdisciplinary”) 5

6. One Health Grand Challenge: Process & Timeline June - October Nov ------- Jan Feb. March SWOT Analysis TAMU Global One Health Issues Major Research Themes Chronic Diseases & Conditions Global Health & Security Accessible & Affordable Quality Healthcare Trans-Discip. Faculty Forums Multi-College Research Proposals Choose Hi-Impact Initiatives Create OH Report Outcomes-Driven Research Plan Sustainability & Governance + Safe & Available Food and Water (impact on human & animal health)

7. Major Thematic Research Areas 7 Safe and Available Food & Water (impact on Human and Animal Health) Global Health & Security Accessible & Affordable Quality Health Care Chronic Diseases & Conditions

8. Societal issues and research topics identified by One Health Campus Council, faculty surveys, and collaborative faculty forums Prevention and treatment of obesity in humans and animals Reproduction/developmental origins of health & disease StressMetabolic diseases Cardio-vascular diseaseWomen’s health Motor-neural diseasesHealthy aging in humans & animals DiabetesImpact of exercise & nutrition Genetic diseases and conditionsGenetics, relating to weight Genomics & metagenomicsBioEngineering

9. Global Health & Security Societal issues and research topics identified by One Health Campus Council, faculty surveys, and collaborative faculty forums Development, delivery and social acceptance of vaccines Pharmaceutical, medical device discoveries and deliveries in safe, efficacious ways Emerging infectious diseasesZoonotic diseases Health security, records, etc.Bio-Informatics Biodefense & bioterrorismRegenerative medicine Antibiotic resistanceDiagnostics, detection Natural products identificationBig data (reduction) New business paradigms for agriculture

10. Accessible & Affordable Healthcare Societal issues and research topics identified by One Health Campus Council, faculty surveys, and collaborative faculty forums Access to quality healthcare in under- served communities Policy issues relating to human & animal health; how impacted by natural and man-made environments Healthcare for humans & animalsPrevention of medical mistakes Health management systems, costs, quality, economics, etc. Education of healthcare, wellness and prevention professionals Remote healthcare & deliveryDevelopment & implementation of healthcare technology, devices etc. Deployable healthcare facilitiesZoonotic pandemics Data value, sharing, miningPatient communications Health educationEnd-of-life care, euthanasia

11. Safe and Available Food & Water (impact on human and animal health) Societal issues and research topics identified by One Health Campus Council, faculty surveys, and collaborative faculty forums Pre-natal under-nutritionBiodefense and bioterrorism in relationship to food and water Food safety and sustainability for growth of a healthy population Urban agriculture as a viable source of healthy nutrition Poverty and hungerFood & water quality & contaminants MicrobiologyPersonalized nutrition Food & water policyHealth systems info. Food wastageFood vs. biofuel competition Food & environ. safetyTreatments for disease

12. Collaborative Proposal Timeline 12 #TimingProcess Step 1Oct-Nov 2013 Decide on relevance of OHGC to your research interests (and vice versa) 2Nov 20 & 21, ‘13Participate in one or more collaboration forums 3Nov – Dec ‘13Identify suitable collaboration partners 4 Nov ’13 – - Jan ‘14 Form collaborative teams – create & submit proposals 5 January 21 ‘14Deadline for proposal submissions 6 Jan 21-Feb 7Window for adding additional collaborators 7 Mid-February ‘14 (exact timing TBD) Proposals reviewed 8 March ‘14OHGC Report submitted to Provost and other TAMU leaders Download detailed pdf at onehealth.tamu.edu/challenge

13. One Health Proposal Template 13 One Health Major Thematic Research Area Collaborative Research Title Collaborative Research Brief Descriptor – impact on One Health (human health, animal health and the connections between health and natural & man-made environments) NameCollege/Dept.Area of Expertise Principle Investigator (PI) PI contact informationTel:Email: Collaborators (1) – (12) Deliverables in the first 12 months     Budget estimate for first 12 months (itemized)     What are the major societal impacts of this proposal’s research in this proposal?       What extra-mural funding could be attracted? Which major TAMU strengths are leveraged?       Download from onehealth.tamu.edu/challenge

14. Agriculture & Life Sciences Nursing Veterinary Medicine & Biomedical Science Geosciences Education & Human Development Science Animal Health Human Health Engineering Medicine Dentistry Architecture Pharmacy Library Rural Public Health Bush School Law Business School Liberal Arts TAMU at Galveston Connection between health and natural & man-made environments Who’s on your One Health Research ‘Dream Team’ for a specific societal issue?

15. Collaborative Proposal Timeline 15 #TimingProcess Step 1Oct-Nov 2013 Decide on relevance of OHGC to your research interests (and vice versa) 2Nov 20 & 21, ‘13Participate in one or more collaboration forums 3Nov – Dec ‘13Identify suitable collaboration partners 4Nov ’13 – Jan ‘14 Form collaborative teams – create & submit proposals (note: all posted online when received) 5 January 21 ‘14Deadline for proposal submissions 6 Jan 21-Feb 7Window for adding additional collaborators 7 Mid-February ‘14 (exact timing TBD) Proposals reviewed 8 March ‘14OHGC Report submitted to Provost and other TAMU leaders Download detailed pdf at onehealth.tamu.edu/challenge

16. Collaborative Proposal Timeline 16 #TimingProcess Step 1Oct-Nov 2013 Decide on relevance of OHGC to your research interests (and vice versa) 2Nov 20 & 21, ‘13Participate in one or more collaboration forums 3Nov – Dec ‘13Identify suitable collaboration partners 4Nov ’13 – Jan ‘14 Form collaborative teams – create & submit proposals (note: all posted online when received) 5 January 21 ‘14Deadline for proposal submissions 6 Jan 21-Feb 7Window for adding additional collaborators 7 Mid-February ‘14 (exact timing TBD) Proposals reviewed (peer reviewed in a review meeting supported by external advisors) 8 March ‘14OHGC Report submitted to Provost and other TAMU leaders Download detailed pdf at onehealth.tamu.edu/challenge

17. 17 onehealth.tamu.edu/challenge

18. Contacts  onehealth.tamu.edu/challenge  Email: onehealth@tamu.edu  Dr. Mike Chaddock Assistant Dean for One Health & Strategic Initiatives 979-845-5617  Merrideth Holub One Health Program Coordinator 979-845-5039 18