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BAA25: Leukocyte Telomere Dynamics, Cardiovascular Aging and Survival in the WHI Long Life Study.

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Presentation on theme: "BAA25: Leukocyte Telomere Dynamics, Cardiovascular Aging and Survival in the WHI Long Life Study."— Presentation transcript:

1 BAA25: Leukocyte Telomere Dynamics, Cardiovascular Aging and Survival in the WHI Long Life Study

2 Telomeres

3 CAC score vs. LTL in 2556 participants in the Family Heart Study

4 BAA25 Specific Aims

5 Testing DNA integrity in WHI DNA Samples

6 BAA25 Study Design

7 BAA25 sample selection Variable Cohort A (n=1,500) Cohort B (n=1,350) BAA set 1 (n=232) Total (n=3,082) CaseNon-caseDeath Age at baseline 63.7 (6.8)61.9 (7.1)66.4 (7.1)63.0 (7.1)65.1 (6.4)63.6 (7.1) Reported race on Form 2 White 250 (50.0%) 675 (50.0%)223 (96.1%)1648 (54.5%) Black 250 (50.0%) 675 (50.0%)9 (3.9%)1434 (46.5%) Reported race on Form 41 White 246 (52.3%)237 (51.8%)166 (59.9%)687 (53.1%)219 (95.6%)1555 (57.0%) Black 225 (47.9%)222 (48.5%)108 (39.0%)607 (46.9%)9 (3.9%)1171 (42.9%) Hispanic 4 (0.9%)2 (0.4%)1 (0.4%)5 (0.4%)0 (0.0%)12 (0.4%) Asian 0 (0.0%) 2 (0.2%)0 (0.0%) Other 1 (0.2%)2 (0.4%)2 (0.7%)11 (0.9%)1 (0.4%)17 (0.6%) In HT 317 (63.4%)310 (62.0%)301 (60.2%)819 (60.7%)232 (100%)1979 (64.2%) dbGAP ok 500 (100%) 1350 (100%)227 (97.8%)3077 (99.8%) Had GWAS data 402 (80.4%)378 (75.6%)415 (83.0%) 1256 (93.0%) 214 (92.2%)2665 (86.5%) Enrolled in LLS 181 (36.2%)161 (32.2%)0 (0.0%)1350 (100%)108 (46.6%)1800 (58.4%) Had LLS DNA 2 129 (25.8%)120 (24.0%)0 (0.0%)1350 (100%)74 (31.8%)1673 (54.3%)

8 BAA25 Specific Aims

9 Andrea LaCroix Cara Carty Abraham Aviv Charles Kooperberg

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