1. CHOLESTAGEL Health Economics Study México March 7, 2008

2. Health Economics Perspectives –No treatment (Davidson et al., Insull et al.) –Statin + placebo (Hunninghake et al., Knapp et al.) –Ezetimibe + placebo (Bays et al., Zema et al.) –Statin + EZE + placebo (no data available) Cholestagel monotherapy Statin + Cholestagel Ezetimibe + Cholestagel Statin + EZE + Cholestagel VS

3. FebMarAprMayJun 2009 Run Data Regulatory Affairs Time Line Health Economic Study Jan Inputs to K.Brito Guiamark Regulatory Affairs New Prod Especial. New Input: Statin + Cholestagel vs Statin + Placebo Dec Run Data Regulatory Affairs Finaly Report Conference Call (Mar 12,’08) To Define: - Ezetimibe + Cholestagel - Statin + Cholestagel 2008