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Mendel and the Laws of Inheritance Biology Dobson High School Hope Finzer
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Who was Gregor Mendel? Austrian monk and scientist His work marks the start of modern genetics Used pea plants to study the passing of traits from generation to generation First person to succeed in predicting how traits are transferred from one generation to the next
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Why did Mendel choose pea plants? Pea plants have both male and female gametes in each plant They reproduce sexually by the transfer of pollen grains from the male gamete to the female ovule The plants reproductive structures are easily identified Short 90 day life cycle Distinct traits: seed shape, seed color, pod shape, pod cover, and height; are some examples
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Pea Traits
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How did Mendel control his experiment? By manually transferring pollen from one plant to another plant with traits that he wanted to test
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What is a cross? Manually transferring pollen from a designated plant with the desired trait to another plant with another desired trait
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What is pollination? The transfer of the male pollen grains to the female organ of flower, resulting in a fertilized mature seed
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Mendel’s Investigations His goal was to explain the patterns of inheritance at the time, no explanation could accurately explain heredity
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What is a hybrid? An organism that receives different genetic information for a trait from each parent
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Mendel’s Experiment Pure-bred – organisms that when allowed to self-fertilize, only produce offspring the parental trait(s) Mendel started by crossing pure-bred tall pea plants with pure- bred short pea plant
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What sort of plants did Mendel get in his first generation? He called the first pair the (P) or parental group and the first generation the first filial group or the F1 generation The F1 generation were all tall but each offspring had both the tall and short genes He then allowed the F1 group self-fertilize and they produced a F2 generation of 3/4th tall plants and 1/4th short plants
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Parent, F1 and F2 generations
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How did this happen? What did Mendel determine? That one trait must be stronger than the other
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What are the types of traits? Dominant – the trait that shows in a hybrid Recessive – trait that does not show in a hybrid
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Dominant & Recessive traits
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Mendel’s Hypothesis Each trait is controlled by something he called a “factor” within the organism We now call this factor a “gene” Gene – genetic factor that controls a trait Since 2 parents contribute to the offspring, there must be 2 genes that separate when gametes form Since traits can disappear for a generation and return unchanged to the next, they must be separate and distinct
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What is an allele? Gene form for each variation of a trait of an organism
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Mendel’s pea plants The pure-bred plants have 2 of the same alleles; example Mendel’s tall pea plants had 2 alleles for tallness The hybrid crosses have alleles of 2 different traits Example Mendel’s F1 generation had 1 allele for tallness and 1 allele for shortness
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Laws of Segregation The 2 alleles for each trait must separate when gametes form A parent passes on at random only 1 allele for each trait to each offspring
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What is a phenotype? The way an organism looks and behaves – the outward appearance regardless of what is in the genetic code Example Mendel’s F1 generation looked tall but had the gene for shortness
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What is a genotype? The gene combination an organism contains; example even though Mendel’s F1 generation was all tall plants, they all had for both tallness and shortness If the organism has the same alleles or traits; example having both tall alleles, usually written as TT; then the organism is considered homozygous
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What is a genotype? If the organism has different alleles or traits; example having one tall allele and one short allele, usually written as Tt; then the organism is considered heterozygous
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What is a Dihybrid cross? A cross involving two different traits
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What happens in the F1 generation? Mendel took a pea plant with round, yellow seeds (these are the dominant traits) and crossed this plant with a pea plant with wrinkled, green seeds (these are the recessive traits)
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What happens in the F1 generation? The genotypes of these are: RRYY and rryy The entire F1 generation were genotype – RrYy The entire F1 generation had the phenotype - round, yellow seeds
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What happens in the F2 generation? Mendel allowed the plants in the F1 generation to self- pollinate andMendel found that there were some plants with round, yellow seeds and some wrinkled, green seeds
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What happens in the F2 generation? He also found that some plants had round, green seeds and some wrinkled, yellow seed He found that the traits appeared in a fixed ratio of: 9 round, yellow 3 round, green 3 wrinkled, yellow 1 wrinkled, green
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Dihybrid Cross To independently sort your alleles (this happens in meiosis), use Use FOIL from your math class. Firsts, Outers, Inners, Lasts GGSS x ggss Put these gamete alleles on the side and top of the punnett square that is now a 4x4 box for a dihybrid cross.
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Dihybrid Cross
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What is Mendel’s Law of Independent Assortment? Genes for different traits are inherited independently of each other
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What is a Punnett Square? Short hand way of finding the expected proportions of possible genotype in offspring
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Monohybrid crosses in the Punnett Square The Punnett Square is 2 boxes tall and 2 boxes wide. One parents’ genotype is separated and placed on the top of the Punnett Square and the other parents genotype is separated and placed along the left side of the boxes
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Monohybrid crosses in the Punnett Square The alleles are then written into the squares that are underneath or beside them and then all possible offspring can be determined
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Examples:
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Exceptions to Mendel’s Laws Incomplete dominance Codominance Sex-linked traits Blood Typing
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Incomplete Dominance Shows the appearance of a third phenotype Example: crossing a red flowering snapdragon with a white flowering snapdragon produces pink flowering snapdragons in the F1 generation
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Incomplete Dominance
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Codominance Both alleles are expressed in the F1 generation Example: Cross a black feathered chicken with a white feathered chicken The F1 generation will show both black and white feathers in a checkerboard pattern
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Codominance
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Sex Linked Traits The expression of traits from genes found on the sex chromosomes – X or Y Example colorblindness
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Sex Linked Traits - a trait determined by alleles carried only on an X chromosome. Males only have 1 X chromosome, therefore any recessive allele present on that X chromosome will be expressed. Colorblindness in humans: recessive allele on the X chromosome. Males: X C Y or X c Y normal color blind Female:X C X C or X C X c or X c X c normal carrier color blind
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Hemophilia inability to produce a protein needed to clot blood. It's often called the "bleeder's disease". It is recessive and found on the X chromosome. Cross X H X hwith X H Y Cross – X C X c with X c Y
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Sex Determination MaleFemale XYXX Sex of an offspring is determined by the father. Write your Punnett Square
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Chromosomal Abnormalities Down's Syndrome (Trisomy 21): There is an extra #21 chromosome. So this person has 47 total chromosomes.
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Turner's Syndrome XO: She has only 45 chromosomes.
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Kleinfelter's Syndrome XXY: He has 47 chromosomes.
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Criminal Syndrome: XYY
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Examples: Incomplete Dominance
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Examples: Codominance
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Examples: Sex-linked traits
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