1. 1/7/15 Starter: What affect do mutations have on proteins? 1/7/15 Mutations and Pedigrees Application: Ws Connection/Exit: Your cousin has hemophilia but no one else in your immediate family does. How could you go about finding where he/she got this disease? Practice: Explain Non-disjunction 125 126

2. January 7, 2015 AGENDA B.6 E Students will Identify and illustrate changes in DNA and evaluate the significance of these changes. by reading and writing during an activity. 1 Starter 2. Activity

3. Date Lecture/ Activity/ Lab Page 11/20 DNA Model 99-100 11/21 DNA Writing 101-102 12/1 DNA Replication Activity 103-104 12/2 DNA Replication Model 105-106 12/3 Cell Cycle Notes 107-108 12/4 Cell Cycle Lab 109-110 12/5 Cell Cycle Writing 111-112 12/8 Cell Cycle Activity 113-114 12/10 RNA Notes 115-116 12/11 Transcription and Translation 117-118 12/15 Protein Synthesis Simulation 119-120 12/16 Mutations 121-122 12/17 Mutations2 123-124 1/7 Mutations and Pedigrees 125-126 Table of Contents 11/19 DNA notes 97-98

4. Changes in DNA

5. Non-Disjunction Ex: Trisomy 21 or Down Syndrome Sometimes, there is an error in meiosis when egg or sperm cells divide resulting in too many or too few chromosomes. How do you think this type of change would impact an organism? Causes an abnormal number of chromosomes and often results in genetic disorders (ex. Down Syndrome, Turner’s Syndrome, Triple-X Syndrome). This can also result in death of the fetus. karyotype

6. Mutation Impact The impact of a mutation on an individual also depends on where and when it occurs. If there was a mutation in the DNA of a zygote, how would that impact the individual? How might a mutation in a skin cell affect an individual?

7. Pedigree Charts Pedigree charts are like a genetic family tree. They can use family information to trace genetic conditions that have been passed along in the family (genetic conditions caused by mutations). Genetic counselors use them to help people analyze their family history and determine the probability of them having or passing on a particular condition (mutation).

8. Pedigree Chart Symbols Empty Square = male Empty Circle = female Filled/Darkened Square = affected male Filled/Darkened Circle = affected female Square/Circle with Slash through = deceased individual

9. Pedigree Chart Example

10. 12/11/13 Starter: What is a “silent” point mutation, and what impact does it have on a point? What is an example? 12/11/13 113 114 Mutations and Pedigrees Application: Ws Connection/Exit: Your cousin has hemophilia but no one else in your immediate family does. How could you go about finding where he/she got this disease? Practice: Notes