1. Working with scientific collaborators as a grad student Eric F. Lock (with notes from Will Thomas)

2. RA setting Does applied biostatistics under supervision of Biostat faculty and external investigator(s). Level of interaction with investigator(s) depends on faculty supervisor and your performance Later in PhD program, perhaps find RA position in another department: work directly with investigator(s)

3. Phases of a collaborative project 1. Understanding the data, finding and resolving its problems –May take 50–75% of time for “analysis” 2. Performing the analysis, reporting results 3. Writing the paper 4. Responding to referee reports about the paper; resubmitting the paper

4. Be prepared Read the study protocol (if available): know how the data was collected and processed If the investigator has published on this subject, read the paper Try to learn some of the science

5. Listen carefully and critically Understand issues motivating the research, and specific questions for your analysis. Ask questions. Investigators may present the issue as a particular statistical problem –Check assumptions carefully Or, they may have little / no understanding of statistical concepts.

6. The data may have problems! Normal individuals Diseased individuals Me

7. Carefully present results Write a report to detail data processing and analysis List quantitative steps in enough detail to replicate analysis Interpret results, don’t just list them

8. Writing the paper Learn the structure of papers in medical journals. Statistician is responsible for figures and sections on analysis methods, results –Altman, et. al., The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med. 2001; 134:663-694. –http://www.consort-statement.org/ Learn to make publication-quality plots in R

9. Communication challenges They assume you know more about their science than you actually do. You assume they know more about statistics than they actually do. Try to avoid interactions like this: –http://www.youtube.com/watch?v=PbODigC ZqL8http://www.youtube.com/watch?v=PbODigC ZqL8