1. © Cancer Research UK 2005 Registered charity number 1089464 Table One: Numbers and rates of new cases, non-Hodgkin lymphoma, UK, 2006 EnglandWalesScotlandN.IrelandUK Cases Males4,7513344371365,658 Females4,0542924441214,911 Persons8,80562688125710,569 Crude rate per 100,000 population Males19.123.117.715.919.1 Females15.719.216.813.615.9 Persons17.321.117.214.817.4 Age-standardised rate (European) per 100,000 population Males16.418.215.015.616.3 95% CI15.916.816.320.213.616.412.918.215.916.8 Females11.613.011.911.211.7 95% CI11.312.011.514.510.813.09.213.311.412.1 Persons13.815.513.213.113.8 95% CI13.514.114.316.712.414.111.514.713.614.1

2. © Cancer Research UK 2005 Registered charity number 1089464 Figure One: Numbers of new cases and age specific incidence rates, by sex, non-Hodgkin lymphoma, UK 2006

3. © Cancer Research UK 2005 Registered charity number 1089464 Figure Two: Age-standardised incidence and mortality rates for NHL in males by region of the world, 2002 estimates

4. © Cancer Research UK 2005 Registered charity number 1089464 Figure Three: Age-standardised incidence rates, non-Hodgkin lymphoma, by sex, EU, 2002

5. © Cancer Research UK 2005 Registered charity number 1089464 Table Two: WHO Classification of NHL B-cell Mature B-cell lymphomas Precursor B-cell lymphoma Small lymphocytic lymphoma Lymphoplasmacytic lymphoma Splenic marginal zone lymphoma Hairy cell leukaemia Plasma cell neoplasms Extranodal marginal zone B-cell lymphoma of mucosa- associated lymphoid tissue (MALT lymphoma) Nodal marginal zone B-cell lymphoma Follicular lymphoma (grades 1, 2, 3a and 3b) Diffuse follicle centre lymphoma Mantle cell lymphoma Diffuse large B-cell lymphoma Mediastinal (thymic) large B-cell lymphoma Intravascular large B-cell lymphoma Primary effusion lymphoma Burkitt lymphoma B-cell proliferations of uncertain malignant potential Lymphomatoid granulomatosis Post-transplant lymphoproliferative disorder, polymorphic

6. © Cancer Research UK 2005 Registered charity number 1089464 Table Two (continued): WHO Classification of NHL T-cell and NK-cell Precursor T- and NK-cell lymphomas Precursor T lymphoblastic lymphoma Blastic NK-cell lymphoma Mature T-cell and NK-cell lymphomas T-cell prolymphocytic leukaemia T-cell large granular lymphocytic leukaemia Aggressive NK-cell leukaemia Adult T-cell lymphoma/leukaemia Extranodal NK-/T-cell lymphoma, nasal type Enteropathy-type T-cell lymphoma Hepatosplenic T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Mycosis fungoides Peripheral T-cell lymphoma unspecified Angioimmunoblastic T-cell lymphoma Anaplastic large cell lymphoma

7. © Cancer Research UK 2005 Registered charity number 1089464 Figure Four: Age standardised (European) incidence rates, non-Hodgkin lymphoma cancer, by sex, GB, 1975-2006

8. © Cancer Research UK 2005 Registered charity number 1089464 Figure Five: Percentage change in age-specific incidence of NHL from 1975, persons, Great Britain

9. © Cancer Research UK 2005 Registered charity number 1089464 Table Three: Examples of cytogenetic/molecular abnormalities in NHL

10. © Cancer Research UK 2005 Registered charity number 1089464 Table Four: Primary extranodal sites for NHL

11. © Cancer Research UK 2005 Registered charity number 1089464 Table Five: Number of deaths and mortality rates, NHL, UK by country, 2007 EnglandWalesScotlandN.IrelandUK Deaths Males2,047130225412,443 Females1,730104213432,090 Persons3,777234438844,533 Crude rate per 100,000 population Males8.28.99.14.88.2 Females6.76.88.04.86.7 Persons7.47.98.54.87.4 Age-standardised rate (European) per 100,000 population Males6.5 7.14.46.5 CI 95%6.26.75.47.76.28.13.15.86.26.7 Females4.03.95.13.54.1 CI 95%3.84.23.14.64.45.82.54.63.94.3 Persons5.15.05.93.95.2 CI 95%5.05.34.45.75.46.53.04.75.05.3

12. © Cancer Research UK 2005 Registered charity number 1089464 Figure Six: Number of deaths and mortality rates, NHL, UK by country, 2007

13. © Cancer Research UK 2005 Registered charity number 1089464 Figure Seven: One-, Five- and Ten-year relative survival for adults diagnosed with NHL in England and Wales during 1971-1995 and followed up to the end of 2001 and period survival estimates for patients alive with a diagnosis at some point during 2000-01

14. © Cancer Research UK 2005 Registered charity number 1089464 Figure Eight: Age-standardised relative five-year survival for men diagnosed with NHL 1990-1994, European countries