1. MASTERGRAFT® Granules & Mini Granules
Medical grade polyporous resorbable ceramic granules
Each granule is composed of:
15% hydroxyapatite (HA)
Slow resorbing3
85% beta-tricalcium phosphate (β-TCP)
Fast resorbing3
80% interconnected porosity3
500 µm average pore diameter3
125 µm average interconnected diameter3
85:15 ratio chosen due to:
Long-term stability3
Resorption rate3
3. Data On File

2. MASTERGRAFT® Granules in Extraction Socket Preservation – Proven Bone Formation7
7. Wakimoto M, Ueno T, Hirata A, Iida S, Aghaloo T, & Moy PK. Histologic Evaluation of Human Alveolar Sockets Treated With an Artificial Bone Substitute Material. J of Cranio Surg ;22(2):
Study Design
Seven patients (ages 35 – 82 years)
Teeth extracted and immediately grafted using MASTERGRAFT® Granules
No primary closure
Implants placed at 4 – 5 months post-grafting
A. MASTERGRAFT® Granules placed into the extracted socket as a graft material. B. MASTERGRAFT® Granules were covered with a cellulose sponge. C. Bone core samples were taken from the grafted sites at 4 months after grafting. D. Installed implant into the grafted site at 4 months after grafting.

3. MASTERGRAFT® Granules in Extraction Socket Preservation Proven Bone Formation7
7. Wakimoto M, Ueno T, Hirata A, Iida S, Aghaloo T, & Moy PK. Histologic Evaluation of Human Alveolar Sockets Treated With an Artificial Bone Substitute Material. J of Cranio Surg ;22(2):
MASTERGRAFT® Granules in Human Extraction Sockets demonstrated:
Osteoconductive scaffold for new bone formation
Maintenance of space within the defect
Support of new blood vessel formation
Support of osteoclasts and osteoblasts for bone remodeling
Effective for repairing bone defects

4. Basic Bone Biology8 Cells Organic Matrix Inorganic Matrix Bone Tissue
(DBM)
Inorganic
(Mineral)
Three main components
Cells
Build, resorb and maintain bone
Organic Matrix
Collagen to resist fracture
Proteins (including BMP)
Inorganic Matrix
Mineral (calcium phosphate) for strength
8. Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)
IRN
Internal Use Only. Do Not Copy. Do Not Circulate. Do Not Distribute.

5. Bone Matrix8-9 Calcium phosphate Composition of Bone
Composition of Inorganic Matrix
Calcium phosphate
Composition of Organic Matrix
8 Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)
9. Einhorn. Biomechanics of Bone. Principles of Bone Biology (1996)
Internal Use Only. Do Not Copy. Do Not Circulate. Do Not Distribute.

6. Bone Grafting8 Extension of Bone Remodeling
Protein Signals
Assuming the right signals exist:
Osteoclasts break down old bone
Release other signals to cells
Osteoblasts form new bone
May reside in transplanted bone
Under right conditions, may recruit other cells
8. Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)
Internal Use Only. Do Not Copy. Do Not Circulate. Do Not Distribute.

7. Bone Graft Incorporation10
Vascularity
– Graft porosity
– Vascularity of site/host
site preparation
Bone Formation
– Bone cells
– Osteoinduction
Graft/Host Union
– Stability of the construct
– Contact area
-Graft quantity
10. Kalfas. Principles of Bone Healing. Neurosurg Focus 10 (4): Article 1, (2001)
Internal Use Only. Do Not Copy. Do Not Circulate. Do Not Distribute.

8. MASTERGRAFT® Granules & Mini Granules
Medical grade polyporous resorbable ceramic granules
Each granule is composed of:
15% hydroxyapatite (HA)
Slow resorbing3
85% beta-tricalcium phosphate (β-TCP)
Fast resorbing3
80% interconnected porosity3
500 µm average pore diameter3
125 µm average interconnected diameter3
85:15 ratio chosen due to:
Long-term stability3
Resorption rate3
3. Data on File