2. Christina Leslie, Lonnie Welch, Chairs Gustavo Stolovitzky, Chair Andrea Califano, Chair Steven Leard, Chris Williams Manolis Kellis, Chair Alex Pico, Barry Demchak, Trey Ideker

3.  13 Keynote Speakers  63 Oral communications  152 Posters  4 Workshops (2 Cytoscape + 2 DREAM)  DREAM: 368 challenge submissions

5. A Dialogue on Reverse Engineering Assessment and Methods 8.5 + 9 Great demand from colleagues wishing to share their data challenges led us to organize winter (n+0.5) and spring challenges (n+1)

6. DREAM was a component of several grants funded in 2014 U54 NIH LINCS Program: Harvard Medical School: Pharmaco Response Signatures and Disease Mechanism OHSU: Extrinsic Perturbations of Cell Physiology and Associated Regulatory Networks U54 DCIC: ISMMS: Data Coordination and Integration Center for LINCS-BD2K Canada NSERC Cancer Genome Collaboratory (the Somatic Mutation Challenges) R21: Univ of Notre Dame: Transcript networks and crowdsourcing to predict drug combinations in malaria parasites And we are also involved in several other submitted grants

7. We organized the first DREAM Hackathon for the AML Challenge at Rice University Organized over 15 Webinars Two community phases following the competitive phase

8. DREAM 8.5 and 9 exceeded previous participation

9. Challenges DREAM 8.5 + 9 Registered Users Leader board Forum Entries Unique Submissions Unique Teams SMC360109412017350 RA3694914523221 AD5201972804324 AML2315831847242 GEP30028962334822 Total178011459669368159

10. Our association has led to a very productive year Feb 2013

11. Come to the Workshop Tuesday at 6:45PM (pizza & drinks on us) Synapse: collaborative platform for DREAM Challenges and much more

12.  http://dreamchallenges.org/ http://dreamchallenges.org/

13. NCI - DREAM Drug Sensitivity Prediction Challenge (Jun 2014) NCI - DREAM Drug Synergy Prediction Challenge (Dec 2014)

14. DREAM 7 - ALS Progression Prediction Challenge (Nov 2014) DREAM6+7: Net Inf & Param Estimation Challenge (Feb 2014)

16. We are organizing several Challenges that we will discuss later today (more info in dreamchallenges.org) DREAM 9.5 (this winter)  ICGC-TCGA DREAM SMC Challenges: RNA and heterogeneity  DREAM Olfaction prediction Challenge  Prostate Cancer Challenge DREAM10 (work in progress, next spring)  ALS Stratification Challenge (Indiegogo campaign)  Drug Synergy Prediction Challenge  Digital Mammography Challenge

17. Thanks: Conference Sponsors and Journals

18. Challenge Organizers

19. Too many thanks to express… The 159 teams that participated and Thea Norman!

20. There is a crew making a short video on DREAM. Let us know if you don’t want to appear in it. There is a board for posting information, jobs, etc. Take a look (I am looking for a post-doc). There will be a workshop at 6:00PM today, and another at 6:45PM tomorrow. Please write your name in the sheets that are going around to know how many pizzas and beer to order!