1. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: 1. Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; 2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; 3. Training in post-genomics and technological dissemination.

2. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: 1. Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; 2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; 3. Training in post-genomics and technological dissemination.

3. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: 1. Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; 2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; 3. Training in post-genomics and technological dissemination.

4. MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA P ROGETTO NEGOZIALE F.I.R.B. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer AIMS: 1. Identification of new panels of molecular markers to better prognostic evaluation of breast cancer lesions, with respect to prediction of the degree of hormone responsiveness and clinical evolution of the disease; 2. Generating a publicly available list of annotations on genes and gene networks relevant to mammary gland and breast cancer biology and to ovarian hormone action; 3. Training in post-genomics and technological dissemination.

5. Work Packages breakdown: Workpackage 4 Activity 1-5: Cellular models Coordination: Second Univ. Napoli Workpackage 2 Activity 1-4: Proteomics Coordination: ISA-Natl Res. Council Workpackage 3 Activity 1: Animal models Coordination: Univ. Milano Workpackage 4 Activity 1-3: Tumor profiling and clinical studies Coordination: Univ. Torino Workpackage 5 Activity 1-4: Bioiformatics Coordination: Second Univ. Napoli Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer

6. Clinical data (hormone responsiveness) Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer MOLECULAR PROFILING gene expression profiling of tumor samples FUNCTIONAL CHARACTERIZATION functional genomic and proteomic analyses in experimental models VALIDATION in situ analyses (tissue arrays and LCM)

7. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer FUNCTIONAL CHARACTERIZATION MOLECULAR PROFILING gene expression profiling of tumor samples functional genomic and proteomic analyses in experimental models in situ analyses (tissue arrays and LCM) clinical studies UniNa2 IRCC-To UniTo IEO-Mi UniFe IDI-Rm UniMi (in vivo) IST-Ge (in vivo) ISA-CNR (proteomics) IRCC-To UniFe UniNa2 ISA-CNR (proteomics) UniFe IRCC-To UniNa2 UniFe IRCC-To BIOINFORMATICS UniNa2ISA-CNR IST-GeIEO-Mi UniToIRCC-To CINECA-Bo UniFe VALIDATION

8. Identification and functional analysis of the gene expression profiles characterizing hormone-responsive breast cancer http://www.hrbc-genomics.net/ Alessandro Weisz Dipartimento di Patologia generale Seconda Università degli Studi di Napoli alessandro.weisz@unina2.it