1. PowerPoint ® Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings PART A 7 The Nervous System

2. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings I can diagram the flow of information through the nervous system  Bell Ringer – List the two major divisions of the nervous system  Agenda  BR  Notes – overview of nervous system  Lab activity – stimulus response time

3. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functions of the Nervous System 1. Sensory input—gathering information  To monitor changes occurring inside and outside the body  Changes = stimuli 2. Integration  To process and interpret sensory input and decide if action is needed 3. Motor output  A response to integrated stimuli  The response activates muscles or glands

4. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functions of the Nervous System Figure 7.1

5. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Structural Classification of the Nervous System  Central nervous system (CNS)  Brain  Spinal cord  Peripheral nervous system (PNS)  Nerves outside the brain and spinal cord  Spinal nerves  Cranial nerves

6. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Classification of the Peripheral Nervous System  Sensory (afferent) division  Nerve fibers that carry information to the central nervous system  Motor (efferent) division  Nerve fibers that carry impulses away from the central nervous system  Two subdivisions  Somatic nervous system = voluntary  Autonomic nervous system = involuntary

7. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Organization of the Nervous System Figure 7.2

8. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings I can describe the supporting cells of the CNS and PNS  Sensory Input  _______________  Central Nervous system  ________________

9. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells  Support cells in the CNS are grouped together as “neuroglia”  Function: to support, insulate, and protect neurons

10. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells  Astrocytes  Abundant, star-shaped cells  Brace neurons  Form barrier between capillaries and neurons  Control the chemical environment of the brain

11. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells Figure 7.3a

12. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells  Microglia  Spiderlike phagocytes  Dispose of debris

13. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells  Ependymal cells  Line cavities of the brain and spinal cord  Circulate cerebrospinal fluid

14. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells  Oligodendrocytes  Wrap around nerve fibers in the central nervous system  Produce myelin sheaths

15. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells Figure 7.3d

16. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells-PNS  Satellite cells  Protect neuron cell bodies  Schwann cells  Form myelin sheath in the peripheral nervous system

17. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Support Cells Figure 7.3e

18. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings I can describe the Anatomy and Physiology of a Neurons Bell Ringer – Matching A. Ependymal cellsB. Oligodentrocytes C.AstrocytesD. Microglia 1.Circulate cerebrospinal fluid 2.Spiderlike phagocytes 3.Control the chemical environment of the brain, brace neurons 4.Produce myelin sheaths in CNS

19. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons  Neurons = nerve cells  Cells specialized to transmit messages  Major regions of neurons  Cell body—nucleus and metabolic center of the cell  Processes—fibers that extend from the cell body

20. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons  Cell body  Nissl substance  Specialized rough endoplasmic reticulum  Neurofibrils  Intermediate cytoskeleton  Maintains cell shape

21. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons Figure 7.4

22. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons  Cell body  Nucleus  Large nucleolus  Processes outside the cell body  Dendrites—conduct impulses toward the cell body  Axons—conduct impulses away from the cell body

23. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons Figure 7.4

24. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons  Axons end in axonal terminals  Axonal terminals contain vesicles with neurotransmitters  Axonal terminals are separated from the next neuron by a gap  Synaptic cleft—gap between adjacent neurons  Synapse—junction between nerves

25. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons  Myelin sheath—whitish, fatty material covering axons  Schwann cells—produce myelin sheaths in jelly roll– like fashion  Nodes of Ranvier—gaps in myelin sheath along the axon

26. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissue: Neurons Figure 7.5

27. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Neuron Cell Body Location  Most neuron cell bodies are found in the central nervous system  Gray matter—cell bodies and unmyelinated fibers  Nuclei—clusters of cell bodies within the white matter of the central nervous system  Ganglia—collections of cell bodies outside the central nervous system

28. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Classification of Neurons  Sensory (afferent) neurons  Carry impulses from the sensory receptors to the CNS  Cutaneous sense organs  Proprioceptors—detect stretch or tension  Motor (efferent) neurons  Carry impulses from the central nervous system to viscera, muscles, or glands

29. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Classification of Neurons Figure 7.7

30. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Classification of Neurons  Interneurons (association neurons)  Found in neural pathways in the central nervous system  Connect sensory and motor neurons

31. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Neuron Classification Figure 7.6

32. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Figure 7.8a Structural Classification of Neurons  Multipolar neurons—many extensions from the cell body

33. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Structural Classification of Neurons  Bipolar neurons—one axon and one dendrite Figure 7.8b

34. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Structural Classification of Neurons  Unipolar neurons—have a short single process leaving the cell body Figure 7.8c

35. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Functional Properties of Neurons  Irritability  Ability to respond to stimuli  Conductivity  Ability to transmit an impulse

36. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nerve Impulses  Resting neuron  The plasma membrane at rest is polarized  Fewer positive ions are inside the cell than outside the cell

37. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nerve Impulses  Depolarization  A stimulus depolarizes the neuron’s membrane  A depolarized membrane allows sodium (Na+) to flow inside the membrane  The exchange of ions initiates an action potential in the neuron Figure 7.9a–b

38. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nerve Impulses  Action potential  If the action potential (nerve impulse) starts, it is propagated over the entire axon  Impulses travel faster when fibers have a myelin sheath

39. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nerve Impulses Figure 7.9c–d

40. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nerve Impulses  Repolarization  Potassium ions rush out of the neuron after sodium ions rush in, which repolarizes the membrane  The sodium-potassium pump, using ATP, restores the original configuration

41. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Nerve Impulses Figure 7.9e–f

42. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses  Impulses are able to cross the synapse to another nerve  Neurotransmitter is released from a nerve’s axon terminal  The dendrite of the next neuron has receptors that are stimulated by the neurotransmitter  An action potential is started in the dendrite Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Neurotrans- mitter is re- leased into synaptic cleft Neurotrans- mitter binds to receptor on receiving neuron’s membrane Vesicle fuses with plasma membrane Synaptic cleft Neurotransmitter molecules Ion channels Receiving neuron Transmitting neuron Receptor Neurotransmitter Na + Neurotransmitter broken down and released Ion channel opensIon channel closes

43. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Neurotrans- mitter is re- leased into synaptic cleft Neurotrans- mitter binds to receptor on receiving neuron’s membrane Vesicle fuses with plasma membrane Synaptic cleft Neurotransmitter molecules Ion channels Receiving neuron Transmitting neuron Receptor Neurotransmitter Na + Neurotransmitter broken down and released Ion channel opensIon channel closes

44. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10, step 1 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron

45. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10, step 2 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Vesicle fuses with plasma membrane Synaptic cleft Ion channels Receiving neuron Transmitting neuron

46. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10, step 3 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Neurotrans- mitter is re- leased into synaptic cleft Vesicle fuses with plasma membrane Synaptic cleft Neurotransmitter molecules Ion channels Receiving neuron Transmitting neuron

47. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10, step 4 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Neurotrans- mitter is re- leased into synaptic cleft Neurotrans- mitter binds to receptor on receiving neuron’s membrane Vesicle fuses with plasma membrane Synaptic cleft Neurotransmitter molecules Ion channels Receiving neuron Transmitting neuron

48. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10, step 5 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Neurotrans- mitter is re- leased into synaptic cleft Neurotrans- mitter binds to receptor on receiving neuron’s membrane Vesicle fuses with plasma membrane Synaptic cleft Neurotransmitter molecules Ion channels Receiving neuron Transmitting neuron Receptor Neurotransmitter Na + Ion channel opens

49. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10, step 6 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Neurotrans- mitter is re- leased into synaptic cleft Neurotrans- mitter binds to receptor on receiving neuron’s membrane Vesicle fuses with plasma membrane Synaptic cleft Neurotransmitter molecules Ion channels Receiving neuron Transmitting neuron Receptor Neurotransmitter Na + Neurotransmitter broken down and released Ion channel opensIon channel closes

50. Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Transmission of a Signal at Synapses Figure 7.10, step 7 Axon terminal Vesicles Synaptic cleft Action potential arrives Synapse Axon of transmitting neuron Receiving neuron Neurotrans- mitter is re- leased into synaptic cleft Neurotrans- mitter binds to receptor on receiving neuron’s membrane Vesicle fuses with plasma membrane Synaptic cleft Neurotransmitter molecules Ion channels Receiving neuron Transmitting neuron Receptor Neurotransmitter Na + Neurotransmitter broken down and released Ion channel opensIon channel closes