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MIPS Molecular Imaging Program at Stanford School of Medicine Department of Radiology Stem Cell Therapy & Cardiovascular Molecular Imaging Joseph Wu, MD, PhD Department of Medicine/Cardiology Department of Radiology/Nuclear Medicine Email: joewu@stanford.edu Stanford
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Coronary heart disease is the #1 cause of morbidity and mortality in the US. CHF is the #1 cause of hospitalization for those age >65 yo. Annual health care costs related to cardiovascular diseases was ~ $220 billion last year. Stem cell transplant is a promising and exciting therapy. Background 2004 American Heart Association Update Orlic D, et al. Nature 2001
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Bone marrow stem cells (BMSC) Endothelial progenitor cells (EPC) Mesenchymal stem cells (MSC) Skeletal myoblasts (SKM) Embryonic stem cells (ESC) Cardiac stem cells (CSC) Cardiac progenitor cells (isl1+) Available Stem Cells **Stem cells are capable of self-renewal, transformation into dedicated progenitor cells, and differentiation into specialized progeny
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Wu JC et al, Circulation 2003 Imaging Embryonic Cardiomyoblasts Survival Optical ImagingMicroPET Imaging
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Imaging Bone Marrow Stem Cells Engraftment in Living Subjects Ahmad Sheikh
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horizontalcoronalsagittal [18F]-FHBG [18F]-FDG Fusion 0%ID/g 1%ID/g 0%ID/g 3%ID/g PET Imaging of ESC Transplant
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PET Imaging of Teratoma Formation and Selective Ablation by GCV Treatment Feng Cao
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Imaging ES Cell Differentiation into Cardiomyocytes Nkx 2.5-eGFP 12 days after embryoid body differentiation
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Comparison of BMMNC vs MSC vs HSC Imaging of stem cell migration & homing Tissue engineering based on ESC EPC and diabetic cardiomyopathy Isolation of resident cardiac stem cells SiRNA knockdown of gene expression Other Projects
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