1. Respiration 呼吸生理

2. 学习要点 呼吸的三个环节 呼吸的三个环节 肺通气的原理 肺通气的原理 肺内压和胸膜腔内压 肺内压和胸膜腔内压 肺通气的阻力 肺通气的阻力 肺容积、肺容量 肺容积、肺容量 肺通气功能的评价 肺通气功能的评价

3. Respiration Definition: Definition: –the bodily processes involved in exchange of oxygen (O 2 ) and carbon dioxide (CO 2 ) between an organism and the environment Consist of Consist of –Inspiration 吸入 : the inhalation of air into the lung –Expiration 呼出 : breathing out

4. The goals of respiration to provide oxygen to the tissues to remove carbon dioxide.

5. Fig. 13.06 Process of respiration:

6. Pulmonary ventilation 肺通气 Definition: The process of moving air into and out of the lungs

7. Structures of pulmonary ventilation 1. Respiratory muscle Primary muscles of respiration: external intercostals ( 肋 间外肌 )& diaphragm （膈肌）

8. 2. Thorax The thorax is a closed compartment that is bounded at the neck by muscles and connective tissue and completely separated from the abdomen by the diaphragm. The thorax is a closed compartment that is bounded at the neck by muscles and connective tissue and completely separated from the abdomen by the diaphragm.

9. Each of the clustered alveoli includes an abundance of pulmonary capillaries, thereby assuring that the ventilated air is brought into close proximity to the “pulmonary” blood, allowing efficient and thorough gas exchange between the air and the blood. 3. Alveoli

10. Extensive branching of alveoli produces lots of surface area for exchange between air and blood. Alveolar and capillary walls are thin, permitting rapid diffusion of gases.

11. Breathing is an active process To inhale – –Contraction of external intercostal muscles  elevation of ribs & sternum  increased front- to-back dimension of thoracic cavity  lowers air pressure in lungs  air moves into lungs – –Contraction of diaphragm  diaphragm moves downward  increases vertical dimension of thoracic cavity  lowers air pressure in lungs  air moves into lungs

12. Breathing is an active process To exhale – –Relaxation of external intercostal muscles & diaphragm  return of diaphragm, ribs, & sternum to resting position  restores thoracic cavity to preinspiratory volume  increases pressure in lungs  air is exhaled

13. Patterns of respiration Eupnea （平静呼吸） : inspiration is active, expiration is passive. Eupnea （平静呼吸） : inspiration is active, expiration is passive. –Abdominal breathing –Thoracic breathing Forced breathing （用力呼吸） : respiratory movement is greatly enhanced during physical exercise Forced breathing （用力呼吸） : respiratory movement is greatly enhanced during physical exercise

14. Principles of pulmonary ventilation Direct force of breathing Direct force of breathing –Pressure gradient between atmosphere and lung Original force of breathing Original force of breathing –Respiratory movement

15. Intrapulmonary pressure = Alveolar pressure =The pressure of air inside the lung alveoli

17. Intrapleural pressure is the pressure within pleural cavity. Intrapleural pressure is the pressure within pleural cavity. Intrapleural pressure （胸内压）

18. Intrapleural pressure Pleural cavity Pleural cavity –Pleural cavity is the closed space between parietal pleura & lungs covered with visceral pleura

20. Formation of intrapleural pressure Fetus lung （胎肺） Fetus lung （胎肺）

21. Formation of intrapleural pressure Air in lungs after delivery Air in lungs after delivery Because the elastic recoil causes the lungs to try to collapse, a negative force is always needed to the outside of the lungs to keep the lungs expanded. This force is provided by negative pressure in the normal pleural space. Because the elastic recoil causes the lungs to try to collapse, a negative force is always needed to the outside of the lungs to keep the lungs expanded. This force is provided by negative pressure in the normal pleural space.

22. Intrapleural pressure Pressures involved Pressures involved –Intrapulmonary pressure =Atmospheric (760 mmHg) pressure –Elastic recoil –Intrapleural pressure

23. Intrapleural pressure Intrapleural pressure = Intrapulmonary pressure – the recoil pressure of the lung Intrapleural pressure = Intrapulmonary pressure – the recoil pressure of the lung Intrapleural pressure = – the recoil pressure of the lung Intrapleural pressure = – the recoil pressure of the lung

24. Physiological significance of intrapleural negative pressure Allow expansion of the lungs Allow expansion of the lungs Facilitate the venous & lymphatic return Facilitate the venous & lymphatic return

25. Pneumothorax （气胸） Air escapes from the lungs or leaks through the chest wall and enters the pleural cavity--- Pneumothorax Air escapes from the lungs or leaks through the chest wall and enters the pleural cavity--- Pneumothorax

26. Lateral Bilateral

27. the goal of therapy for spontaneous pneumothorax is to eliminate air from the pleural space and to terminate an air leak

28. Resistances to Ventilation Elastic resistance: The ability of an elastic structure to resist stretching or distortion. 70% Elastic resistance: The ability of an elastic structure to resist stretching or distortion. 70% Non-elastic resistance: 30% Non-elastic resistance: 30%

29. Compliance of the lungs Compliance ( 顺应性 ): the expand ability of elastic tissues when acted on by foreign forces or the extent to which the lungs expand for each unit increase in pressure. Compliance ( 顺应性 ): the expand ability of elastic tissues when acted on by foreign forces or the extent to which the lungs expand for each unit increase in pressure. C=ΔV/ΔP (L/cmH 2 O) C=ΔV/ΔP (L/cmH 2 O) Elastic Resistance (R) Elastic Resistance (R)C=1/R

30. The sources of elastic resistance of the lung Elastic resistance of the lungs Elastic resistance of the lungs –1/3 Elastic forces of the lung tissue itself （肺 回缩力） –2/3 Elastic forces caused by surface tension （表面张力） of the fluid that lines the inside walls of the alveoli

31. Surface tension 表面张力 Tension of a liquid's surface. Due to the forces of attraction between molecules Tension of a liquid's surface. Due to the forces of attraction between molecules

32. Surface tension The surface tension at the air-water interfaces within the alveoli. The surface tension at the air-water interfaces within the alveoli. At an air-water interface, the attractive forces between the water molecules (surface tension) make the alveoli like stretched balloons that constantly try to shrink and resist further stretching. At an air-water interface, the attractive forces between the water molecules (surface tension) make the alveoli like stretched balloons that constantly try to shrink and resist further stretching.

33. Pierre Simon Laplace (1749 - 1827) Laplace ’ s law: P=2T/r

34. In the absence of surfactant, the attraction between water molecules can cause alveolar collapse. Laplace ’ s law: P=2T/r

35. Alveolar surfactant 表面活性物质 Secreted by type II alveolar epithelial cells Secreted by type II alveolar epithelial cells Surfactant is a complex mixture of Surfactant is a complex mixture of –Several phospholipids ( 二软脂酰卵磷脂 dipalmitoyl phosphatidyl choline, DPPC) –Surfactant-associated proteins –Ions (calcium)

37. Alveolar surfactant Physiological effect of surfactant Physiological effect of surfactant Reduces surface tension –Maintains the stability of the alveoli in different size –Keeps the dryness of the alveoli –Eases expansion of lung (increases compliance)

38. Laplace ’ s law: P=2T/r T a =T b T a >T b ra>rb Pa<Pb Pa=Pb

40. Neonatal respiratory distress syndrome ( 新生儿呼 吸窘迫综合症 NRDS): lack of surfactant cyanosis retraction of soft tissue on inspiration

41. Non-elastic resistance Airway resistance 气道阻力 : 80~90% Airway resistance 气道阻力 : 80~90% –Is caused by friction among gas molecules and between gas molecules and the inner wall of airway. –R  1/r 4 Inertial resistance 惯性阻力 Inertial resistance 惯性阻力 Viscous resistance 粘滞阻力 : The effect of surface friction between a particle and a liquid when the particle moves through the liquid. Viscous resistance 粘滞阻力 : The effect of surface friction between a particle and a liquid when the particle moves through the liquid.

42. Regulation of the respiratory smooth muscle by autonomic nervous system: Regulation of the respiratory smooth muscle by autonomic nervous system: –Vagus nerve: Ach  M receptor  Contraction –Sympathetic nerve: NE   2 -receptor  Relaxation Regulation of the respiratory smooth muscle by endocrine or paracrine factors: Regulation of the respiratory smooth muscle by endocrine or paracrine factors: –Histamine, Bradykinin  Contraction –NE, E, Isoproterenol  Relaxation

43. Pulmonary volumes and capacities Spirometer Spirometer a spirometer---a device used to measure lung health.

44. Pulmonary volumes Tidal volume ( 潮气量 TV) Tidal volume ( 潮气量 TV) –Volume of air inspired or expired with each normal breath Normal value: 400~500 ml Inspiratory reserve volume ( 补吸气量 IRV) Inspiratory reserve volume ( 补吸气量 IRV) –Amount of air that can be inspired above and beyond TV Normal value: 1500~2000 ml

45. Expiratory reserve volume ( 补呼气量 ERV) Expiratory reserve volume ( 补呼气量 ERV) –Amount of air that can be expired after a tidal expiration Normal value: 900~1200 ml Residual volume ( 残气量 RV) Residual volume ( 残气量 RV) –the volume of air remaining in the lungs at the end of a maximal exhalation Normal value: M 1500 ml, F 1000 ml

46. The tidal volume is the amount of air moved in (or out) of the airways in a single breathing cycle. Inspiratory and expiratory reserve volumes, are, respectively, the additional volume that can inspired or expired; all three quantities sum to the lung’s vital capacity. The residual volume is the amount of air that must remain in the lungs to prevent alveolar collapse.

47. Pulmonary capacities Inspiratory capacity 深吸气量 Inspiratory capacity 深吸气量=IRV+TV Functional residual capacity 功能残气量 Functional residual capacity 功能残气量 –Is the volume of air that still remains in the lungs after expiration of a resting tidal volume. –FRC=ERV+RV Vital volume ( 肺活量 Vital capacity, VC) Vital volume ( 肺活量 Vital capacity, VC) –Is the maximal of air that a person can expire after a maximal inspiration –VC=TV+IRV+ERV –Normal value: M 3500 ml, F 2500 ml

48. Pulmonary capacities Total lung capacity 肺总量 Total lung capacity 肺总量 –The maximal volume of air the lungs can accommodate –=VC+RV

50. Pulmonary capacities Forced expiratory volume ( 用力肺活量， timed vital volume 时间肺活量 ) Forced expiratory volume ( 用力肺活量， timed vital volume 时间肺活量 ) –The maximal volume of air that can be exhaled as fast as possible from the lungs following a maximal inspiration –Normal value: 1st sec. (FEV1) -- 83 ％ 2nd sec. (FEV2) -- 96 ％ 3rd sec. (FEV3) -- 99 ％

52. Pulmonary ventilation Pulmonary ventilation ( 每分通气量 V E ) Pulmonary ventilation ( 每分通气量 V E ) –The total amount of air inspired (or expired) during one minute –V E = TV x breaths/min = 500 X12 = 6000 ml

53. Pulmonary ventilation Alveolar ventilation ( 肺泡通气量 V A ) Alveolar ventilation ( 肺泡通气量 V A ) –The amount of inspired air that is available for gas exchange each minute –V A = (TV - dead space 无效腔 ) x breaths/min = (500-150) X12 = 4200 ml = (500-150) X12 = 4200 ml

54. Dead space

55. Anatomical dead space Anatomical dead space –Volume in respiratory passageways which can not be exchanged –~150ml Alveolar dead space Alveolar dead space –Alveoli which have little or no blood supply and cease to function in gas exchange –Normally ~0 Dead space

56. Because of the anatomic dead space, “Fresh” inspired air is diluted by the left over air remaining in the lungs from the previous breathing cycle.

57. Increased depth of breathing is far more effective in evaluating alveolar ventilation than is an equivalent increase in breathing rate.