1. The Human Circulatory System and the Components of Blood

2. Circulatory System The circulatory system is also referred to as the cardiovascular system Functions very closely with digestive and respiratory systems Basic system requires: 1. a pump (heart); 2. vessels/pathways (veins, arteries, capillaries); 3. fluid (blood).

3. Circulatory System Key Roles: Maintains homeostasis – body temperature regulation – controls blood pressure Delivers and removes substances throughout body DeliversRemoves - nutrients - oxygen - messages (via hormones) - toxins - metabolic wastes - carbon dioxide - toxins

4. Components of Blood a sample of blood can be spun in a centrifuge – high speed, circular motion – causes blood to separate by the weights of its components

5. Components of Blood

6. Erythrocytes: Red Blood Cells Produced in bone marrow, stored in spleen Constantly destroyed and replaced Distinct biconcave shape – Flattened disc that is pinched in the centre – Makes it flexible for traveling through various blood vessels No nucleus No mitochondria Contains special hemoglobin molecule

7. Hemoglobin Complex protein made up of 4 protein chains, each with a central iron-containing heme group Iron gives RBCs their distinct red colour Iron binds with oxygen (4 O 2 molecules per hemoglobin molecule) – blood becomes oxygenated Iron is recycled in bone marrow

8. Anemia Medical condition when there is a less than normal amount of hemoglobin in the blood Less hemoglobin, less O 2 being delivered throughout the body Can be caused by a genetic disorder (e.g., sickle cell anemia or thalassemias) or by a great loss of blood

9. Leucocytes: White Blood Cells Produced in bone marrow Larger than red blood cells, but much fewer in number Amoeboid-shaped Contain nucleus and lysosomes

10. Leucocytes: White Blood Cells Part of body’s immune response system Detects and defends body from infection and diseases Lysosomes digest foreign bacteria Pus is formed at site of infection – White blood cells (living & dead) + bacteria – Body’s natural “soap” An increase in WBCs indicate the body is fighting an infection

11. Leukemia Cancer of the white blood cells White blood cells are produced in overabundance in the bone marrow Bone marrow becomes crowded and is unable to manufacture other blood cells Malignant WBCs can leave bone marrow, travel blood stream and affect other organs

12. Platelets Fragments of special cells from the bone marrow Important for circulatory system repair Form blood clots

13. Platelets – Blood Clotting Detect damaged blood vessels Burst and release special adhesive chemicals Platelets stick together and form a platelet plug Through chemical reactions, forms strand-like fibrin molecule A mesh of fibrin strands forms a blood clot Clot protects body from losing blood through the damaged vessel Holds vessel wound together until it can be reconstructed with new tissue growth

14. Hemophilia X-linked genetic disorder Individual lacks special proteins that are needed for creating blood clots Can bruise easily Can bleed excessively if cut – sometimes bleeding to death

15. Shock An actual medical condition – can be life-threatening Body (or parts of body) shut down because circulatory system cannot meet oxygen demands of some vital organs Body reduces blood flow to arms and legs so it can maximize O 2 getting to the vital organs (in body’s core) Can result from loss of blood, extreme fright or emotional disturbance First Aid: Put person in half upright position, keep warm Apply direct pressure to any areas of severe bleeding Get (call for) medical help