1. KARYOTYPING What do your chromosomes look like?

2. Karyotype Cell treated with chemical to stop in metaphase Chromosomes stained Picture taken Enlarged Cut out Matched by banding patterns Arranged by size and location of centromere

4. Click HERE to try your hand at matching up pairs of homologous chromosomes.HERE

5. Normal Male

6. Normal Female

7. What can you tell from a Karyotype?

8. From a Karyotype You can tell –Correct number of chromosomes –Correct size and shape of chromosomes –Gender

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10. Female with Trisomy 21 Down Syndrome

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12. Male with Trisomy 21 Down Syndrome

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14. Deletion of Long Arm Chromosome 4

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16. Extra X – Klinefelter’s Syndrome

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18. Missing X – Turner’s Syndrome

19. SKY – Spectral Karyotypes Uses fluorescent “tags” specific to each chromosome

21. Sources http://www.biology.arizona.edu/human_bio/activiti es/karyotyping/karyotyping.htmlhttp://www.biology.arizona.edu/human_bio/activiti es/karyotyping/karyotyping.html http://www.biology.arizona.edu/Human_Bio/curre nt/new_karyotyping/new_karyotyping.htmlhttp://www.biology.arizona.edu/Human_Bio/curre nt/new_karyotyping/new_karyotyping.html http://en.wikipedia.org/wiki/Template:Chromosom al_abnormalitieshttp://en.wikipedia.org/wiki/Template:Chromosom al_abnormalities