1. Science & Technology Centers Program National Science Foundation Science & Technology Centers Program Bryn Mawr Howard MIT Princeton Purdue Stanford UC Berkeley UC San Diego UIUC NSF STC 2010

2. Science & Technology Centers Program Bryn Mawr College: D. Kumar Howard University: C. Liu MIT: M. Sudan (co-PI), P. Shor. Purdue University (lead): W. Szpankowski (PI) Princeton University: S. Verdu (co-PI) Stanford University: A. Goldsmith (co-PI) University of California, Berkeley: Bin Yu (co-PI) University of California, San Diego: S. Subramaniam UIUC: P.R. Kumar, O. Milenkovic. Bin Yu, U.C. Berkeley Sergio Verdú, Princeton Peter Shor, MIT Andrea Goldsmith, Stanford Wojciech Szpankowski, Purdue 2

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4. The Information Revolution started in 1948, with the publication of: A Mathematical Theory of Communication. The digital age began. Claude Shannon: Shannon information quantifies the extent to which a recipient of data can reduce its statistical uncertainty. “semantic aspects of communication are irrelevant...” Applications Enabler/Driver: CD, iPod, DVD, video games, Internet, Facebook, WiFi, mobile, Google,.. Design Driver: universal data compression, voiceband modems, CDMA, multiantenna, discrete denoising, space-time codes, cryptography,... 4

5. Science & Technology Centers Program 5 Three Theorems of Shannon Theorem 1 & 3. [Shannon 1948; Lossless & Lossy Data Compression] compression bit rate ≥ source entropy H(X) for distortion level D: lossy bit rate ≥ rate distortion function R(D) Theorem 2. [Shannon 1948; Channel Coding ] In Shannon’s words: It is possible to send information at the capacity through the channel with as small a frequency of errors as desired by proper (long) encoding. This statement is not true for any rate greater than the capacity.

6. Science & Technology Centers Program 6 What is Information 1 ? C. F. Von Weizs¨acker: “Information is only that which produces information” (relativity). “Information is only that which is understood” (rationality). “Information has no absolute meaning”. Informally Speaking: A piece of data carries information if it can impact a recipient’s ability to achieve the objective of some activity in a given context within limited available resources. Event-Driven Paradigm: Systems, State, Event, Context, Attributes, Objective: Objective function objective(R,C) maps systems’ rule R and context C in to an objective space. Definition 1. The amount of information (in a faultless scenario) I(E) carried by the event E in the context C as measured for a system with the rules of conduct R is I R,C ( E ) = cost[objective R ( C(E )), objective R ( C ( E ) + E )] where the cost (weight, distance) is a cost function. 1 Russell’s reply to Wittgenstein’s precept “whereof one cannot speak, therefore one must be silent” was “... Mr. Wittgenstein manages to say a good deal about what cannot be said.”

7. Science & Technology Centers Program We aspire to extend classical Information Theory to meet challenges of today posed by rapid advances in biology, modern communication, and knowledge extraction. We need to extend traditional formalisms for information to include: structure, time, space, and semantics, and other aspects such as: dynamical information, physical information, representation- invariant information, limited resources, complexity, and cooperation & dependency. 7

8. Science & Technology Centers Program Structure: Measures are needed for quantifying information embodied in structures (e.g., information in material structures, nanostructures, biomolecules, gene regulatory networks, protein networks, social networks, financial transactions). Time & Space: Classical Information Theory is at its weakest in dealing with problems of delay (e.g., information arriving late maybe useless or has less value). Semantics & Learnable Information: How much information can be extracted for data repository? Is there a way to account for the meaning or semantics from data?

9. Science & Technology Centers Program Other related aspects of information: Limited Computational Resources: In many scenarios, information is limited by available computational resources (e.g., cell phone, living cell). Representation-invariance: How to know whether two representations of the same information are information equivalent? Cooperation: Often subsystems may be in conflict (e.g., denial of service) or in collusion (e.g., price fixing). How does cooperation impact information (nodes should cooperate in their own self-interest)?

10. Science & Technology Centers Program Manfred Eigen (Nobel Prize, 1967) “The differentiable characteristic of the living systems is Information. Information assures the controlled reproduction of all constituents, ensuring conservation of viability.... Information theory, pioneered by Claude Shannon, cannot answer this question... in principle, the answer was formulated 130 years ago by Charles Darwin”. P. Nurse, (Nature, 2008, “Life, Logic, and Information”): Focusing on information flow will help to understand better how cells and organisms work.... the generation of spatial and temporal order, cell memory and reproduction are not fully understood. A. Zeilinger (Nature, 2005)... reality and information are two sides of the same coin, that is, they are in a deep sense indistinguishable

11. Science & Technology Centers Program The overarching vision of the Center for Science of Information is to develop principles and human resources guiding the extraction, manipulation, and exchange of information, integrating space, time, structure, and semantics. 11

12. Science & Technology Centers Program Advance science and technology through a new quantitative understanding of the representation, communication and processing of information in biological, physical, social and engineering systems. Some Specific Center’s Goals: define core theoretical principles governing transfer of information, develop meters and methods for information, apply to problems in physical and social sciences, and engineering, offer a venue for multi-disciplinary long-term collaborations, explore effective ways to educate students, train the next generation of researchers, broaden participation of underrepresented groups, transfer advances in research to education and industry. 12

13. Science & Technology Centers Program 13 Research Thrusts: 1. Information Flow in Biology 2. Information Transfer in Communication 3. Knowledge: Extraction, Computation & Physics S. Subramaniam A. Grama V. Anantharam T. Weissman S. Kulkarni M. Atallah Create a shared intellectual space, integral to the Center’s activities, providing a collaborative research environment that crosses disciplinary and institutional boundaries.

14. Science & Technology Centers Program 14 D. Kumar R. Hughes M. Ward B. Ladd Integrate cutting-edge, multidisciplinary research and education efforts across the center to advance the training and diversity of the work force

15. Science & Technology Centers Program Industrial affiliate program in the form of consortium: Considerable intellectual resources Access to students and post-docs Access to intellectual property Shape center research agenda Solve real-world problems Industrial perspective Knowledge Transfer Director: Ananth Grama 15 Develop effective mechanism for interactions between the center and external stakeholder to support the exchange of knowledge, data, and application of new technology.

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17. Science & Technology Centers Program Life Sciences 1.Knowledge extraction from data a.Integrating diverse datasets b.Defining the granularity of data c.Statistical methods with regularization d.Biology-constrained methods e.Information metrics f.Dealing with context 2.Dealing with noise in data a.Robustness of knowledge extraction to noise b.How to deal with missing data? 3.Classification of modularity from data a.Specification and identification of modules (functional, spatial, temporal, etc.) from data b.Quantifying information content of modules c.Quantitative and qualitative comparison of modules 4.Dealing with dynamical data a.How to deal with multivariate and high dimensional time series data? b.Understanding spatio-temporal information processing in systems c.Identifying suitable granularity and context for analyzing data 17

18. Science & Technology Centers Program Communication 1.Delay in Information Theory a.Quantifying the temporal value of information b.Information theory for finite block lengths c.Tradeoffs between delay, distortion, and reliability in feedback systems 2.Information and computation a.Quantifying fundamental limits of in-network computation, and the computing capacity of networks for different functions b.Complexity of distributed computation in wireless and wired networks c.Information theoretic study of aggregation for scalable query processing in distributed databases 3.New measures and notions of information a.Soft-information (beliefs) in rate distortion theory b.Semantics in information: framework, probabilistic modeling c.Modern communication networks 4.Interface with life sciences thrust a.Furthering our information theoretic understanding of deletion, substitution, and insertion channels b.Information theoretic models for evolution c.Models for stimuli d.Communication models for intra-neuron signaling e.Models to predict the behavior of various systems, ranging from intra-cellular signaling, to tissues, individuals, colonies, and ecosystems 18

19. Science & Technology Centers Program Knowledge Management 1.Information science for collaborative computing and inference 2.Semantic, goal-oriented, and communication 3.Learning and inference in networks 4.Environmental modeling and statistical emulation 19