1. Consider testing if person is: – Overweight or obese with additional risk factor for diabetes – Age 45 or older Obtain: A1C or FPG or 2-hour plasma glucose post 75g OGTT Repeat testing every 3 years if results are normal In patients with increased risk, identify and treat other CVD risk factors American Diabetes Association. Diabetes Care 2010; 33;(Suppl1).

2.  Objective: To determine if A1C is an optimal method for diagnosing diabetes and detecting pre-diabetes compared to IFG and IGT  Results: ◦ Detection of pre-diabetes  IFG: 69.1%  IGT: 59.5%  A1C: 23.6%  Conclusion: A1C is less sensitive for detecting pre- diabetic individuals than IFG and IGT Lorenzo et al. Diab Care. 2010 June 23. Epub ahead of print.

3. American Diabetes Association. Diabetes Care 2010; 33;(Suppl.1):S11-61..

5. 43%37%19%14%16%12% *P<0.05; †P<0.0001. Stratton IM, et al. BMJ. 2000;321(7258):405- 412. Lower-extremity amputation or fatal peripheral vascular disease† Microvascular disease† Cataract extraction† Myocardial infarction† Heart failure* Stroke* Cardiovascular complications

6. *Multivariate regression – adjusted for age and risk factor; †Multivariate regression – adjusted for age, sex, and risk factor. EPIC-Norfolk: The European Prospective Investigation into Cancer in Norfolk was a prospective population study of 4,662 men and 5,570 women aged 45-79 years. Average follow-up time was 6.3 years. Khaw KT et al. Ann Intern Med. 2004;141:413-420. 1% Increase in A1C Above 5% 1% Increase in A1C Above 7% CHDCVDTotal Mortality Increase in Relative Risk (%)* Increase in Relative Risk (%)† 0 10 20 30 40 40% 16% 26% Men 0 5 10 15 20 25 30 Total Mortality CHDCVD 21% 24% 25% Total Mortality CHDCVD Women 21% 28% 20%