1. Neoplasia p.1 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Neoplasia Definitions Nomenclature Characteristics of benign and malignant neoplasms Epidemiology Carcinogenesis

2. Neoplasia p.1 63Squamous cells papilloma 286CIN (slides with CIN I and CIN II) 90CIN III 242Squamous cell carcinoma (larynx) 68 Adenocarcinoma (large intestine) 69 Small cell lung carcinoma (= SCLC)

3. -multiple projections -with a central central fibrovascular cores -covered by a typical, stratified squamous epithelium Squamous cells papilloma

6. CIN Cytological features: Cytological features: - loss in the uniformity of the individual cells - loss in the uniformity of the individual cells - considerable pleomorphism - hyperchromatic and enlarged nuclei - more abundant mitotic figures also in abnormal locations within epithelium Loss of the typical architectural orientation of cells Intact basal membrane review a few slides as they differ in grade (CIN 1 and CIN 2)

7. Cervical epithelium without CIN

8. CIN

11. - normal epithelium totally replaced by immature atypical cells, exhibiting no surface differentiation - intact basal membrane CIN III

14. Squamous cell carcinoma (keratinizing) (larynx) groups of malignant cells of epithelial origin with marked focal dyskeratosis infiltrating soft tissues

15. Squamous cell carcinoma (keratinizing) (larynx)

17. Adenocarcinoma (large intestine) Cytologically malignant columnar cells forming neoplastic glands, often cribriform, with central necrosis. Differentiation may range from tall, columnar cells to undifferentiated, frankly anaplastic masses.

18. Adenocarcinoma (large intestine)

20. Small cell lung carcinoma (= SCLC) The epithelial cells are small, with scant cytoplasm, ill- defined cell borders, finely granular nuclear chromatin (salt and pepper pattern), and absent or inconspicuous nucleoli. The cells are round, oval, and spindle-shaped, and nuclear molding is prominent. In general, tumor cells are smaller than small resting lymphocytes. The mitotic count is high. The cells grow in clusters that exhibit neither glandular nor squamous organization. Necrosis is common and often extensive. Grading is inappropriate, since all small cell carcinomas are high grade.

21. Small cell lung carcinoma (= SCLC)