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Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s Programmes at the University.

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Presentation on theme: "Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s Programmes at the University."— Presentation transcript:

1 Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s Programmes at the University of Pécs and at the University of Debrecen Identification number: TÁMOP-4.1.2-08/1/A-2009-0011

2 CELL-SCAFFOLD INTERACTION Dr. Judit Pongrácz Three dimensional tissue cultures and tissue engineering – Lecture 11 Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s Programmes at the University of Pécs and at the University of Debrecen Identification number: TÁMOP-4.1.2-08/1/A-2009-0011

3 TÁMOP-4.1.2-08/1/A-2009-0011 I Scaffolds I Pre-made network of biomaterial One cell type seeded on one scaffold Several cell types seeded on a scaffold simultaneously or sequentially

4 TÁMOP-4.1.2-08/1/A-2009-0011 II Scaffolds II CO 2 Fused beeds Fused cube porogen Cube porogen Fused irregular Fleece

5 TÁMOP-4.1.2-08/1/A-2009-0011 Cell line cells nestling on a scaffold A549 (lung adenocarcinoma cell line)

6 TÁMOP-4.1.2-08/1/A-2009-0011 Matrigel® Matrigel: is the trade name for a gelatinous protein mixture secreted by mouse sarcoma cells This mixture resembles the complex extracellular environment found in many tissues Matrigel is marketed by BD Biosciences

7 TÁMOP-4.1.2-08/1/A-2009-0011 Primary SAEC (Small Airway Epithelial Cells) in matrigel

8 BIOFACTORS Dr. Judit Pongrácz Three dimensional tissue cultures and tissue engineering – Lecture 12 Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s Programmes at the University of Pécs and at the University of Debrecen Identification number: TÁMOP-4.1.2-08/1/A-2009-0011

9 TÁMOP-4.1.2-08/1/A-2009-0011 Biofactors PI3K Wnt GSK3 ATF2  -TrCP Wnt TCF PLC  TAK SMAD Elk1 HES Frizzled Disheveled FGF receptor BMP TGF-  BMP and TGF-  receptor Notch Jagged or Delta-like ligands ICD Cytosol Nucleus Adjacent cell  -catenin accumulation  -catenin degradation ProliferationDifferentiationMigration

10 TÁMOP-4.1.2-08/1/A-2009-0011 Main growth factors (GFs) used in tissue engineering VEGF VEGF – vascular endothelial growth factor KGF KGF – keratinocyte growth factor TGF-  TGF-  – transfroming growth factor beta BMP BMP – bone morphogenic protein FGF FGF – fibroblast growth factor PDGF PDGF – platelet-derived growth factor

11 TÁMOP-4.1.2-08/1/A-2009-0011 VEGF Primarily in endothelial cells Dimeric glycoprotein Four splice variants Receptors: VEGFR-1 and VEGFR-2

12 TÁMOP-4.1.2-08/1/A-2009-0011 TGF-  Superfamily member MW 21 kDa Synthesized by platelets and macrophages Induces differentiation in multiple cell types of various tissues

13 TÁMOP-4.1.2-08/1/A-2009-0011 BMP Osteoinductive peptide family Belongs to the TGF-  superfamily MW 25-30 kDa

14 TÁMOP-4.1.2-08/1/A-2009-0011 FGF 23 members of the family Multiple functions on multiple cell types Human FGF-2 18 kDa non-glycosylated polypeptide binds to heparin and heparan sulfate

15 TÁMOP-4.1.2-08/1/A-2009-0011 PDGF Exists as a dimer Two chains MW 14-17 kDa each Synthesized by platelets, macrophages, endothelium, connective tissue Effects: Mitogenesis, angiogenesis, macrophage activation

16 TÁMOP-4.1.2-08/1/A-2009-0011 Delivery of growth factors Injected Diffused from scaffolds Released from gels Genetically engineered into cells

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