1. Improve your R&D Effectiveness and Manage Your Intellectual Property Assets with Luxid ® for Life Sciences

2. Copyright © 2008 TEMIS - All Rights ReservedSlide 2 Luxid ® - Complete Corporate Solution 1.Gather textual data from any sources 2.Perform domain-specific & detailed content analysis 3.Discover and understand information 4.Share information and alerts 2 Luxid ® Repository 3 4 1

3. Copyright © 2008 TEMIS - All Rights ReservedSlide 3 Luxid ® For Life Sciences Commercial Databases Public and web sources 2 Luxid ® Repository 3 4 1 Enterprise Content Management Additional information data sources +

4. Copyright © 2008 TEMIS - All Rights ReservedSlide 4 Luxid ® For Life Sciences 2 Luxid ® Repository 3 4 1 + Biological Entities Relationships Extraction of genes + proteins & interactions Medical Entities Relationships Extraction of diseases, disorders and adverse events Chemical Entities Relationships Extraction of chemical names and structures Additional domain-specific annotators

5. Copyright © 2008 TEMIS - All Rights ReservedSlide 5 Luxid ® For Life Sciences 2 Luxid® Repository 3 4 1 + Additional domain-specific features Sub-Structure SearchProtein Interactions

6. Copyright © 2008 TEMIS - All Rights ReservedSlide 6 Scenarios Use Case # 1 Target Validation Using Luxid® Scenario: find information about potential targets or biomarkers for a disease inside a corpus of patents Benefits: combine faceted search, multiple analysis and semantic navigation Use Case # 2 FTO Evaluation Around Chemical Structures Scenario: make a first analysis of recent patents to find chemical structures related to a disease Benefits: search directly documents using chemical structure, perform analysis on rich metadata content

7. Copyright © 2008 TEMIS - All Rights ReservedSlide 7 Secure and individual Luxid access

8. Copyright © 2008 TEMIS - All Rights ReservedSlide 8 Search for patents on ‘atherosclerosis’

9. Copyright © 2008 TEMIS - All Rights ReservedSlide 9 Results list and perform an analysis

10. Copyright © 2008 TEMIS - All Rights ReservedSlide 10 View top applicants in the field

11. Copyright © 2008 TEMIS - All Rights ReservedSlide 11 Save to share with colleagues

12. Copyright © 2008 TEMIS - All Rights ReservedSlide 12 View top inventors in the field

13. Copyright © 2008 TEMIS - All Rights ReservedSlide 13 Prepare a cross-tab applicants vs inventors

14. Copyright © 2008 TEMIS - All Rights ReservedSlide 14 Turned into an informative dashboard

15. Copyright © 2008 TEMIS - All Rights ReservedSlide 15 Inspect mentionned proteins

16. Copyright © 2008 TEMIS - All Rights ReservedSlide 16 Time analysis – Check new trends

17. Copyright © 2008 TEMIS - All Rights ReservedSlide 17 Proximity graph reveals associations between ‘atherosclerosis’ and ‘proteins’ – See sentence extracts with ‘IL-6’

18. Copyright © 2008 TEMIS - All Rights ReservedSlide 18 Proximity graph reveals associations between ‘IL-6’ and ‘chemical compounds’ – See sentence extracts with ‘atorvastatins’

19. Copyright © 2008 TEMIS - All Rights ReservedSlide 19 Save the dashboard again…

20. Copyright © 2008 TEMIS - All Rights ReservedSlide 20 One step further : Semantic network graph around ‘atorvastatin’ Conclusion: ‘atorvastatin’ is an effective treatment of atherosclerosis

21. Copyright © 2008 TEMIS - All Rights ReservedSlide 21 Let’s search for ‘atorvastatin’ analogues present in the patent full text by using the sub-structure search

22. Copyright © 2008 TEMIS - All Rights ReservedSlide 22 Start a new search around statins

23. Copyright © 2008 TEMIS - All Rights ReservedSlide 23 Access to stored information Exportable and sharable dashboard reports