1. 11 James K. Murray, Jr., PhD, Associate Professor & Chair, Chemistry Department, Immaculata University Barry F. Stein, PhD Senior Project Consultant Mary J. Burch, PhD Project Consultant

2. 22 jmurray@Immaculata.edu steinbf@verizon.net maryjburch@gmail.com

3. 33 Nano Overview Demonstrative Experiments Lessons & lesson plans Adaptation to your class

4. 44 Opening Salvo Profiles and backgrounds Objectives Quiz Nanotechnology Beginnings Feynman Article Definitions, Opportunities and Applications Videos Nano Gold Experiment Tyndall Effect Hands-on Au Experiment Tele-experimentation thru NTEN portal BREAK Workshop Content

5. 55 New Nano Materials Quantum Dots & Hard Drive Heads Carbon Nanotubes Disease Diagnosis & Treatment Experiment: Nanomaterial Effects Physical: Particle Size Effects Chemical: Surface Area Effects Nanoproducts and Wrap Up Today’s Products Risk & Risk Perception Post Quiz and Future Work LUNCH Workshop Content Continued

6. 66  The ability to manipulate and control materials at the level of atoms and molecules to design new functionality. The nanoscale: 1nm=10 -9 m  An enabling science that – applies to all disciplines – blurs the distinction between biology, chemistry, & physics Nanotechnology will be pervasive in the upcoming decades New career opportunities for students What is Nanotechnology?

7. 7 Nano Size Cell Size & Scale  http://learn.genetics.utah.edu/content/begin/cells/s cale/ http://learn.genetics.utah.edu/content/begin/cells/s cale/

8. 88 Generally nanotechnology deals with structures 100 nanometers or smaller, and involves developing materials or devices within that size.

9. 99 The Economic Driver of the 21st Century “Nanotechnology’s impact on health, wealth and security of the world’s people is expected to be at least as great as the combined influences in this century of antibiotics, the integrated circuit and human-made polymers.” Federal Interagency Working Group Report on Nanotechnology

10. 10  What's 100,000 times thinner than a strand of hair? A nanometer. Discover the nanotech boom in Berkeley, where researchers are working to unlock the potential of nanoscience to battle global warming and disease.  http://www.youtube.com/watch?v=S4CjZ-OkGDs http://www.youtube.com/watch?v=S4CjZ-OkGDs

11. 11 Magnification vs. Year Scanning Probe Microscopy (1980’s+) 0.0001 µm (0.1 nm)Atoms and molecules Electron Microscope (1930’s+) 0.01 µm IC’s and Material Science Optical Microscope (1660-1800) 2µm Water microorganisms 1600 1700 1800 1900 2000 1000 1 1000000

12. 12 Carbon nanotube

13. 13 ► As of August 2009, there were more than 1015 manufacturer-identified nanotech products 1 1 The Woodrow Wilson International Center for Scholars

14. 14

15. 15  Materials-nanotubes  Life Sciences-drug development & delivery, innovative therapies, diagnostics  Sensors-physical, chemical, biological  Ultra-high speed computing, Molecular Electronics  Nanomachines  Green technology: Fuel cells, solar cells, new light sources, microbial cleanup, filtration

16. 16 Clean Water Challenge Now! NanofiltrationNano for Remediation  Nanostructured ◦ Arrays of capillaries ◦ Carbon nanotubes  Nanoreactive Membranes ◦ Functionalized nanoparticles ◦ Dendritic polymers  Single enzyme nanoparticles  Zeolites  Nanoscale semiconductor photocatalysts  Carbon nanotubes

17. 17 Need to do a more general slide on risk, risk perception

18. 18 Nano-Sized: Risk and Risk Perception Carbon nanotubes: Scarring in mouse lung Carbon nanoparticles: no effect C&E News, Oct 27, 2009 "A key question to be answered is whether or not a particular nanoparticle has toxic or hazardous properties that are truly different from identical particles in their bulk form.“ Mark Wiesner, Duke University, Center for the Environmental Implications of NanoTechnology Nanotech Protection: Current Safety Equipment May Not Be AdequateNanotech Protection: Current Safety Equipment May Not Be Adequate (Oct. 16, 2009) — Canadian engineers suggest that research is needed into the risks associated with the growing field of nanotechnology manufacture so that appropriate protective equipment can be developed

19. 19 Hot Nanotechnology Career Areas Medicine: diagnostic s and therapeutics (e.g., drug delivery) Computers: the next generation Energy: capture, storage, & use; fuel cells, batteries Environmental remediation: in conjunction with genetically- modified (GM) microbes Robotics: many uses Manufacturing: sel f-assembly; “bottom-up” fabrication of novel materials Commerce: Radio Frequency Identification (RFID) “smart” tags Space exploration: space elevator NSF: By 2015 we need 2 million nanotech-savvy workers

20. 20 Colloidal Gold Experiment  Objective ◦ Gain an understanding that nano size leads to changes in optical properties of materials  Process ◦ Conduct Experiment ◦ Discuss & identify  How it relates to topics that you teach  Where this material can be inserted into your classroom

21. 21 Mesogold Mesosilver “The Blue Man” as seen on Today Show How do I know there are gold particles there? Why is the color pinkish-purple?

22. 22

23. 23 Color Wheel Shows Complementary Colors

24. 24 Nanospectra Biosciences, Inc.

25. 25 Cancer Treatment Application A Rifle Shot  Cisplatin is a drug that treats cancer successfully. Unfortunately, the drug can harm healthy cells as well as cancerous ones.  Nano gold particles combined with DNA deliver drugs directly to where they are needed inside a patient’s body.  Once inside the cancer cells, cisplatin is then released, selectively killing the cancer cells.

26. 26 Nano Size Experiments  Objectives ◦ Demonstrate that nano size leads to changes in the way that a material interacts both physically and chemically ◦ Gain an understanding of surface area and size and how they play a role in physical and chemical reactions  Process ◦ Conduct Experiments ◦ Discuss & identify  How they relate to topics that you teach  Where this material can be inserted into your classroom

27. 27 Your Task Deliver two nanotechnology lessons to two classes

28. 28 Nanotechnology for Middle/High School Teachers  A three-credit graduate course that serves as an introduction to nanotechnology, a field that is redefining the scientific landscape and will shape the future scientific careers of students ◦ One third of the course is on-line nanotechnology content ◦ Two-thirds is focused on the experiments and development of lesson plans that the individual teacher will deliver to students in the fall following the course