1. Copyright © 2009 Pearson Education, Inc. Art and Photos in PowerPoint ® Concepts of Genetics Ninth Edition Klug, Cummings, Spencer, Palladino Chapter 12 DNA Organization in Chromosomes Copyright © 2009 Pearson Education, Inc.

2. 12.1Viral and Bacterial Chromosomes Are Relatively Simple DNA Molecules

3. Copyright © 2009 Pearson Education, Inc. Figure 12.1

4. Copyright © 2009 Pearson Education, Inc. Table 12.1

5. Copyright © 2009 Pearson Education, Inc. Figure 12.2

6. Copyright © 2009 Pearson Education, Inc.

7. Figure 12.3

8. Copyright © 2009 Pearson Education, Inc.

9. 12.2 Supercoiling Facilitates Compaction of the DNA of Viral and Bacterial Chromosomes

10. Copyright © 2009 Pearson Education, Inc. Figure 12.4

11. Copyright © 2009 Pearson Education, Inc. Figure 12.4a

12. Copyright © 2009 Pearson Education, Inc. Figure 12.4b

13. Copyright © 2009 Pearson Education, Inc. Figure 12.4c

14. Copyright © 2009 Pearson Education, Inc. Figure 12.4d

15. Copyright © 2009 Pearson Education, Inc. 12.4DNA Is Organized into Chromatin in Eukaryotes 12.4.1 Chromatin Structure and Nucleosomes

16. Copyright © 2009 Pearson Education, Inc. DNA Fun Fact Length of DNA in human cell ~ 2 meters No. of cells in human body ~10 14 So, total length of DNA in human body ~ 2 x 10 14 meters = 2 x 10 11 km Distance from Earth to Sun ~ 1.5 x 10 8 km This means that you have enough DNA in your body to stretch back and forth between the Earth and Sun 1000 times!

17. Copyright © 2009 Pearson Education, Inc. Table 12.2

18. Copyright © 2009 Pearson Education, Inc. Figure 12.8

19. Copyright © 2009 Pearson Education, Inc. Figure 12.8a

20. Copyright © 2009 Pearson Education, Inc. Figure 12.8b

21. Copyright © 2009 Pearson Education, Inc. ~200 bp 147 bp digest linker DNA

22. Copyright © 2009 Pearson Education, Inc.

23. Figure 12.9

24. Copyright © 2009 Pearson Education, Inc.

26. 12.4DNA Is Organized into Chromatin in Eukaryotes 12.4.2 High Resolution Studies of the Nucleosome Core

27. Copyright © 2009 Pearson Education, Inc. Figure 12.10

28. Copyright © 2009 Pearson Education, Inc. 12.4DNA Is Organized into Chromatin in Eukaryotes 12.4.3 Heterochromatin

29. Copyright © 2009 Pearson Education, Inc. 12.5 Chromosome Banding Differentiates Regions along the Mitotic Chromosome

30. Copyright © 2009 Pearson Education, Inc. Figure 12.11

31. Copyright © 2009 Pearson Education, Inc. Figure 12.12

32. Copyright © 2009 Pearson Education, Inc. Figure 12.13

33. Copyright © 2009 Pearson Education, Inc. 12.6 Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA

34. Copyright © 2009 Pearson Education, Inc. Figure 12.14

35. Copyright © 2009 Pearson Education, Inc. 12.6 Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA 12.6.1 Satellite DNA

36. Copyright © 2009 Pearson Education, Inc. Figure 12.15

37. Copyright © 2009 Pearson Education, Inc. Figure 12.16

38. Copyright © 2009 Pearson Education, Inc. 12.6 Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA 12.6.2 Centromeric DNA Sequences

39. Copyright © 2009 Pearson Education, Inc. Centromeric DNA Sequences “point” versus “regional” centromeres

40. Copyright © 2009 Pearson Education, Inc. Figure 12.17

41. Copyright © 2009 Pearson Education, Inc. 12.6 Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA 12.6.3 Telomeric DNA Sequences 12.6.4 Middle Repetitive Sequences: VNTRs and STRs 12.6.5 Repetitive Transposed Sequences: SINEs and LINEs 12.6.6 Middle Repetitive Multiple-Copy Genes

42. Copyright © 2009 Pearson Education, Inc. 12.7 The Vast Majority of a Eukaryotic Genome Does Not Encode Functional Genes “C- value paradox”