1. Chapter 16 The Molecular Basis of Inheritance

2. Question? u Traits are inherited on chromosomes, but what in the chromosomes is the genetic material?

3. Qualifications

4. For testing: u Name(s) of experimenters u Outline of the experiment u Result of the experiment and the importance of the result

5. Griffith - 1928

6. Griffith’s Experiment

7. Result

8. Problem

9. Avery, McCarty and MacLeod - 1944

10. Hershey- Chase 1952

11. Bacteria with Phages

12. Phage Components

13. Used Tracers

14. Experiment

16. Result DNA is the genetic material.

17. Picture Proof

18. Chargaff - 1947

19. Chargaff’s Rule

20. Why?

22. Watson and Crick - 1953

23. Rosalind Franklin

24. Book

25. DNA Composition

26. DNA Backbone

27. Nitrogen Bases

30. Chargaff’s Rule

33. Watson and Crick

34. Replication

35. Models for DNA Replication

36. Replication Models

37. Meselson - Stahl late 1950’s

42. Results

43. Replication - Preview

45. Origins of Replication

46. Prokaryotic

47. Eukaryotic Cells

49. DNA Elongation

50. Energy for Replication

52. Problem of Antiparallel DNA

54. Leading Strand

55. Lagging Strand

56. Priming

59. Okazaki Fragments

60. Enzymes

61. Other Proteins in Replication

62. Enzyme Summary

65. DNA Replication Error Rate

66. Reasons for Accuracy

67. DNA Repair

68. Example:

69. Xeroderma Pigmentosum Cancer Protected from UV

70. Thymine Dimers

71. Excision Repair

73. Problem - ends of DNA

74. Result

76. Telomeres

79. Implication

80. Telomerase

82. Comment

83. Summary u Know the Scientists and their experiments. u Why DNA is an excellent genetic material. u How DNA replicates. u Problems in replication.