1. OTIS ANNUAL RESEARCH MEETING JUNE 2010 Asthma and Asthma Medications in Pregnancy Study A Vaccines and Medications in Pregnancy Survelliance System (VAMPSS) Project

2. VAMPSS Project Vaccines and Medications in Pregnancy Surveillance System “VAMPSS” A Collaboration of: American Academy of Allergy Asthma and Immunology Organization of Teratology Information Specialist (OTIS) Slone Epidemiology Center at Boston University (SEC)

3. VAMPSS Project VAMPSS is a new nationwide post-marketing surveillance system established to comprehensively monitor the use and safety of vaccines and medications during pregnancy The VAMPSS system provides a coordinated effort involving: 1. prospective registry surveillance coordinated by OTIS 2. case-control surveillance coordinated by SEC

4. Asthma and Asthma Medications in Pregnancy Study-A VAMPSS Project Study began in November 2009 Prospective, observational cohort study Coordinating center is at the University of California, San Diego

5. Purpose The Asthma and Asthma Medications in Pregnancy study is researching the effects of short-acting and long-acting beta agonists used for the treatment of asthma in pregnancy

6. Study Participation Self-enrollment 4-5 phone interviews (intake, 20wk, 32wk, outcome, and 6 month post-partum) Medical records pertaining to the pregnancy and outcome of the pregnancy

7. Total Enrollment to Date Total as of June 7, 2010 Short-acting Beta- agonists 9 Long-acting Beta- agonists 13 Controls13 Total Enrolled35

8. Who Should be Referred? GroupsCriteria Short-Acting Beta Agonist Diagnosed with asthma Exposure to a short-acting beta agonist Less than 20 weeks gestation Long-Acting Beta Agonist Diagnosed with asthma Exposure to a long-acting beta agonist (Formoterol or Salmeterol) Less than 20 weeks gestation Non-Disease Controls Pregnant women who are less than 20 weeks gestation

9. How to Refer? Toll-free number at 877-311-8972 to refer patient OR provide the patient our toll-free number Contact via email at d4johnson@ucsd.edu Fax a referral sheet to OTIS which is found on our website at www.otispregnancy.org