Download presentation
Presentation is loading. Please wait.
Published byRafe Burns Modified over 9 years ago
1
Systematic identification of 3′-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons by Jonathan E. Cohen, Philip R. Lee, and R. Douglas Fields Philosophical Transactions B Volume 369(1652):20130509 September 26, 2014 ©2014 by The Royal Society
2
Activity-dependent, post-transcriptional gene regulation experiment. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369:20130509 ©2014 by The Royal Society
3
(Opposite.) Rapid, post-transcriptional regulation in hippocampal neurons mirrors activity- regulated genes in DRG axons. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369:20130509 ©2014 by The Royal Society
4
Discovery of enriched motifs for destabilized and stabilized genes. 3′-UTR analysis by MEME on downregulated (destabilized) and upregulated (stabilized) transcripts by MEME identifies miRNA-binding sites. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369:20130509 ©2014 by The Royal Society
5
Predicted miRNAs are developmentally regulated in the hippocampus and may control nervous system development. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369:20130509 ©2014 by The Royal Society
6
miR-485 blocks NGF-induced neurite outgrowth in PC12 cells. miR-485 overexpression inhibits NGF-induced neurite outgrowth in PC12 cells. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369:20130509 ©2014 by The Royal Society
7
miR-485 decreases tau expression in hippocampal neurons. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369:20130509 ©2014 by The Royal Society
8
miR-485 overexpression controls tau expression and axonal outgrowth in hippocampal neurons. miR-485-5p overexpression reduced the extent of axonal outgrowth in hippocampal neurons. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369:20130509 ©2014 by The Royal Society
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.