1. Patients Treated with Leksell Gamma Knife ® 1968-2014

2. Global Statistics Slide Number  Cumulative volume3  Indications treated annually4  2014 regional volume5  Average regional volume 6  Global case mix by year7  Cumulative regional case mix 8  2014 case mix9  Cumulative case mix10  Cumulative indications treated11  Indications treated 201412  Case mix by country13  Indications fractionated 2014 43 Indication-Specific Statistics  Vascular Disorders16  Functional Disorders21  Ocular Disorders26  Benign Tumors30  Malignant Tumors 37 Region & Country Statistics Asia (excluding Japan)  Cumulative volume46  Indications treated annually47  Cumulative case mix48  Cumulative indications treated 49  2014 volume50  China cumulative volume51  China case mix52  South Korea cumulative volume53  South Korea case mix54  Taiwan cumulative volume 55  Taiwan case mix 56 TABLE OF CONTENTS 2 North America  Cumulative volume58  Indications treated annually59  Cumulative case mix60  Cumulative indications treated 61  2014 volume62  United States cumulative volume63  United States case mix64 Japan  Cumulative volume66  Indications treated annually67  Cumulative case mix68  Cumulative indications treated 69  2014 volume70 Latin America  Cumulative volume72  Indications treated annually73  Cumulative case mix74  Cumulative indications treated 75  2014 volume76 Europe  Cumulative volume78  Indications treated annually79  Cumulative case mix80  Cumulative indications treated 81  2014 volume82  Turkey cumulative volume83  Turkey case mix84  United Kingdom cumulative volume85  United Kingdom case mix86 Middle East & Africa  Cumulative volume88  Indications treated annually89  Cumulative case mix90  Cumulative indications treated 91  2014 volume92 Please note that making detailed year over year comparisons is not advised due to the annual variability in number of centers reporting. The percent of centers reporting has ranged from 68% to 100%. The rate for 2014 is 95%. Data for specific countries is only provided for those countries with 7 or more Gamma Knives. The Society has increasingly improved the specificity of indication-specific reporting to allow for a more refined representation of clinical practice. For example, Essential Tremor treatments were reported within 'Other Functional Disorders' prior to 2012, but separately for the past three years. Please reference the Leksell Gamma Knife ® Society when using or distributing the data in this presentation and do not hesitate to contact the Secretariat for any questions regarding the data. CAVEATS

3. Leksell Gamma Knife ® OVER 884,000 PATIENTS TREATED THROUGH 2014, WORLDWIDE 3 68-100% centers reporting 1991 reflects cumulative numbers

4. Leksell Gamma Knife ® INDICATIONS TREATED ANNUALLY THROUGH 2014, WORLDWIDE 4 68-100% centers reporting 1991 reflects cumulative numbers

5. Leksell Gamma Knife ® TOTAL NUMBER OF TREATMENTS BY REGION 2014 95% centers reporting 17.632 1.070 21.536 2.950 12.448 5 18.608

6. Leksell Gamma Knife ® AVERAGE NUMBER OF PERFEXION TREATMENTS PER REGION AND CENTER 2014 AVERAGE NUMBER OF TREATMENTS PER CENTER WORLDWIDE: 293 US: 183 Canada: 316 6 95% centers reporting

7. Leksell Gamma Knife ® GLOBAL CASE MIX BY YEAR 13% 27% 49% 46 % 38% 33% 36% 34% 40% 42% 45% 48% 46% 45% 46% 43% 44% 43% 46% 45% 47% 43% 44% 33% 31% 38% 42% 41% 42% 39% 35% 37% 34% 31% 33% 32%33% 35% 38% 39% 40% 51% 40% 27% 22% 19% 18% 16% 14% 13% 12% 11% 10% 11% 10% 11% 10% 3% 1% 2% 1% 2% 3% 1% 4% 6% 8% 9% 8% 9% 8% 7% 1% 7% 7 68-100% centers reporting 1991 reflects cumulative numbers

8. Leksell Gamma Knife ® CASE MIX FOR 1991 – 2014 BY REGION 27% 16% 31% 15% 71% 7% 21% 30% 13% 15% 49% 7% 51% 5% 46% 6% 20% 2% 1% 41% 6% 1% 67% 4% 28% 16% 8 68-100% centers reporting 1991 reflects cumulative numbers

9. Leksell Gamma Knife ® CASE MIX FOR 2014 BY REGION 29% 32% 76% 24% 17% 57% 52% 49% 18% 47% 67% 25% 15% 11% 5% 19% 12% 4% 5% 6% 9% 5% 13% 1% 9 95% centers reporting

10. Leksell Gamma Knife ® TREATMENTS BY INDICATION 1991 – 2014, WORLDWIDE 325.009 386.895 3.317 64.995 103.991 10 68-100% centers reporting 1991 reflects cumulative numbers

11. Leksell Gamma Knife ® INDICATIONS TREATED 1991 – 2014, WORLDWIDE 11 *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 * 68-100% centers reporting 1991 reflects cumulative numbers

12. Leksell Gamma Knife ® INDICATIONS TREATED 2014, WORLDWIDE 12 95% centers reporting

13. Leksell Gamma Knife ® CASE MIX BY COUNTRY 2014 CHINAJAPAN SOUTH KOREA 13 2% 95% centers reporting

14. Leksell Gamma Knife ® CASE MIX BY COUNTRY 2014 TAIWAN UNITED KINGDOM 14 2.2% 95% centers reporting

15. Leksell Gamma Knife ® CASE MIX BY COUNTRY 2014 UNITED STATES 15 TURKEY 2% 95% centers reporting

16. Leksell Gamma Knife ® VASCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE 16 68-100% centers reporting 1991 reflects cumulative numbers

17. Leksell Gamma Knife ® VASCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE 86.987 353 5.905 10.136 610 17 68-100% centers reporting 1991 reflects cumulative numbers

18. Leksell Gamma Knife ® VASCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE 18 68-100% centers reporting 1991 reflects cumulative numbers

19. 5.352 Leksell Gamma Knife ® VASCULAR DISORDERS, PATIENTS TREATED 2014 WORLDWIDE 1.393 268 172 4 19 2.4% 95% centers reporting

20. Leksell Gamma Knife ® ARTERIOVENOUS MALFORMATIONS, CUMULATIVE PATIENTS TREATED WORLDWIDE 20 68-100% centers reporting 1991 reflects cumulative numbers

21. Leksell Gamma Knife ® FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE 21 68-100% centers reporting 1991 reflects cumulative numbers

22. Leksell Gamma Knife ® FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE 56.617 2.824 2.110 1.531 787 475 267 105 82 75 65 18 23 10 3 22 * 68-100% centers reporting 1991 reflects cumulative numbers 2.4% *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

23. Leksell Gamma Knife ® FUNCTIONAL DISORDERS TREATED ANNUALLY, WORLDWIDE 23 * 68-100% centers reporting 1991 reflects cumulative numbers *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

24. Leksell Gamma Knife ® FUNCTIONAL DISORDERS, PATIENTS TREATED 2014 WORLDWIDE 4.468 195 162 38 34 28 27 21 12 6 14 2 24 95% centers reporting

25. Leksell Gamma Knife ® TRIGEMINAL NEURALGIA, CUMULATIVE PATIENTS TREATED WORLDWIDE 25 68-100% centers reporting 1991 reflects cumulative numbers

26. Leksell Gamma Knife ® OCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE 26 68-100% centers reporting 1991 reflects cumulative numbers

27. Leksell Gamma Knife ® OCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE 350 321 2.646 27 68-100% centers reporting 1991 reflects cumulative numbers

28. Leksell Gamma Knife ® OCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE 28 68-100% centers reporting 1991 reflects cumulative numbers

29. Leksell Gamma Knife ® OCULAR DISORDERS, PATIENTS TREATED 2014 WORLDWIDE 227 33 3 29 95% centers reporting

30. Leksell Gamma Knife ® BENIGN TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE 30 68-100% centers reporting 1991 reflects cumulative numbers

31. Leksell Gamma Knife ® BENIGN TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE 125.760 85.324 63.692 9.189 8.277 6.254 5.527 5.194 3.912 3.341 3.311 2.869 1.985 120 90 31 164 68-100% centers reporting 1991 reflects cumulative numbers 1.9% 1.7%

32. Leksell Gamma Knife ® BENIGN TUMORS TREATED ANNUALLY, WORLDWIDE 32 68-100% centers reporting 1991 reflects cumulative numbers

33. Leksell Gamma Knife ® BENIGN TUMORS, PATIENTS TREATED 2014 WORLDWIDE 7.632 13.031 4.459 881 749 512 422 396 306 251 237 164 158 91 70 45 33 1.7% 95% centers reporting

34. Leksell Gamma Knife ® MENINGIOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE 34 68-100% centers reporting 1991 reflects cumulative numbers

35. Leksell Gamma Knife ® VESTIBULAR SCHWANNOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE 35 68-100% centers reporting 1991 reflects cumulative numbers

36. Leksell Gamma Knife ® PITUITARY ADENOMAS, CUMULATIVE PATIENTS TREATED WORLDWIDE 36 68-100% centers reporting 1991 reflects cumulative numbers

37. Leksell Gamma Knife ® MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE 37 68-100% centers reporting 1991 reflects cumulative numbers

38. Leksell Gamma Knife ® MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE 386.895 250 334 1.079 2.032 13.055 35.141 38 68-100% centers reporting 1991 reflects cumulative numbers

39. Leksell Gamma Knife ® MALIGNANT TUMORS TREATED ANNUALLY, WORLDWIDE 39 68-100% centers reporting 1991 reflects cumulative numbers

40. Leksell Gamma Knife ® MALIGNANT TUMORS, PATIENTS TREATED 2014 WORLDWIDE 29.405 39 69 135 184 985 1.530 40 95% centers reporting

41. Leksell Gamma Knife ® METASTATIC TUMOR, CUMULATIVE PATIENTS TREATED WORLDWIDE 41 68-100% centers reporting 1991 reflects cumulative numbers

42. Leksell Gamma Knife ® GLIAL TUMOR, CUMULATIVE PATIENTS TREATED WORLDWIDE 42 68-100% centers reporting 1991 reflects cumulative numbers

43. Leksell Gamma Knife ® INDICATIONS FRACTIONATED 2014, USING THE LEKSELL FRAME OR WITH EXTEND™ 40 210 362 51 centers reporting 43

44. Leksell Gamma Knife ® INDICATIONS FRACTIONATED 2014, USING THE LEKSELL FRAME OR WITH EXTEND™ 51 centers reporting 44

45. Asia excluding Japan 1990 - 2014 PATIENTS TREATED WITH LEKSELL GAMMA KNIFE ®

46. 46 Leksell Gamma Knife ® OVER 235,000 PATIENTS TREATED THROUGH 2014 ASIA (excluding Japan) 68-100% centers reporting 1991 reflects cumulative numbers

47. 47 Leksell Gamma Knife ® INDICATIONS TREATED ANNUALLY ASIA (excluding Japan) 68-100% centers reporting 1991 reflects cumulative numbers

48. Leksell Gamma Knife ® CASE MIX 1991 - 2014 ASIA (excluding Japan) 355 12.412 39.023 64.698 120.246 48 68-100% centers reporting 1991 reflects cumulative numbers

49. Leksell Gamma Knife ® INDICATIONS TREATED 1991 – 2014, ASIA (excluding Japan) 49 * 68-100% centers reporting 1991 reflects cumulative numbers *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

50. Leksell Gamma Knife ® CASE MIX 2014 ASIA (excluding Japan) 21 1.120 11.103 3.127 6.165 50 100% centers reporting

51. Leksell Gamma Knife ® OVER 157,000 PATIENTS TREATED THROUGH 2014 CHINA 51 68-100% centers reporting 1991 reflects cumulative numbers

52. Leksell Gamma Knife ® CASE MIX 1991 - 2014 CHINA 9.129 82.592 42.368 289 23.362 52 68-100% centers reporting 1991 reflects cumulative numbers

53. Leksell Gamma Knife ® OVER 42,000 PATIENTS TREATED THROUGH 2014 SOUTH KOREA 53 68-100% centers reporting 1991 reflects cumulative numbers

54. Leksell Gamma Knife ® CASE MIX 1991 - 2014 SOUTH KOREA 16.302 17.991 50 7.326 1.216 54 68-100% centers reporting 1991 reflects cumulative numbers

55. Leksell Gamma Knife ® OVER 13,000 PATIENTS TREATED THROUGH 2014 TAIWAN 55 68-100% centers reporting

56. Leksell Gamma Knife ® CASE MIX 1993 - 2014 TAIWAN 1.055 3.034 12 6.549 2.981 56 68-100% centers reporting

57. North America 1987 - 2014 PATIENTS TREATED WITH LEKSELL GAMMA KNIFE ® 57

58. 58 Leksell Gamma Knife ® OVER 225,000 PATIENTS TREATED THROUGH 2014 NORTH AMERICA 68-100% centers reporting 1991 reflects cumulative numbers

59. 59 Leksell Gamma Knife ® INDICATIONS TREATED ANNUALLY NORTH AMERICA 68-100% centers reporting 1991 reflects cumulative numbers

60. Leksell Gamma Knife ® CASE MIX 1991 - 2014 NORTH AMERICA 63.547 35.604 16.703 109.738 128 60 68-100% centers reporting 1991 reflects cumulative numbers

61. Leksell Gamma Knife ® INDICATIONS TREATED 1991 – 2014, NORTH AMERICA 61 * 68-100% centers reporting 1991 reflects cumulative numbers *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

62. Leksell Gamma Knife ® CASE MIX 2014 NORTH AMERICA 4.444 2.372 766 10.035 15 62 93% centers reporting

63. Leksell Gamma Knife ® OVER 215,000 PATIENTS TREATED THROUGH 2014 UNITED STATES 63 68-100% centers reporting 1991 reflects cumulative numbers

64. Leksell Gamma Knife ® CASE MIX 1991 - 2014 UNITED STATES 59.999 34.002 106.260 15.813 107 64 68-100% centers reporting 1991 reflects cumulative numbers

65. Japan 1990 - 2014 PATIENTS TREATED WITH LEKSELL GAMMA KNIFE ® 65

66. Leksell Gamma Knife ® OVER 210,000 PATIENTS TREATED THROUGH 2014 JAPAN 66 68-100% centers reporting 1991 reflects cumulative numbers

67. Leksell Gamma Knife ® INDICATIONS TREATED ANNUALLY JAPAN 67 68-100% centers reporting 1991 reflects cumulative numbers

68. Leksell Gamma Knife ® CASE MIX 1991 - 2014 JAPAN 4.930 15.366 107 41.423 150.456 68 2.3% 68-100% centers reporting 1991 reflects cumulative numbers

69. Leksell Gamma Knife ® INDICATIONS TREATED 1991 – 2014, JAPAN 69 * 68-100% centers reporting 1991 reflects cumulative numbers *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

70. Leksell Gamma Knife ® CASE MIX 2014 JAPAN 133 614 9 2.268 9.424 70 100% centers reporting

71. Latin America 1985 - 2014 PATIENTS TREATED WITH LEKSELL GAMMA KNIFE ® 71

72. 72 Leksell Gamma Knife ® OVER 5,500 PATIENTS TREATED THROUGH 2014 LATIN AMERICA 68-100% centers reporting 1991 reflects cumulative numbers

73. Leksell Gamma Knife ® INDICATIONS TREATED ANNUALLY LATIN AMERICA 73 68-100% centers reporting 1991 reflects cumulative numbers

74. Leksell Gamma Knife ® CASE MIX 1991 - 2014 LATIN AMERICA 1.744 1.217 60 2.376 358 74 68-100% centers reporting 1991 reflects cumulative numbers

75. Leksell Gamma Knife ® INDICATIONS TREATED 1991 – 2014, LATIN AMERICA 75 * 68-100% centers reporting 1991 reflects cumulative numbers *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

76. Leksell Gamma Knife ® CASE MIX 2014 LATIN AMERICA 261 205 8 498 98 76 90% centers reporting

77. Europe 1968 - 2014 PATIENTS TREATED WITH LEKSELL GAMMA KNIFE ® 77

78. Leksell Gamma Knife ® OVER 180,000 PATIENTS TREATED THROUGH 2014 EUROPE 78 68-100% centers reporting 1991 reflects cumulative numbers

79. Leksell Gamma Knife ® INDICATIONS TREATED ANNUALLY EUROPE 79 68-100% centers reporting 1991 reflects cumulative numbers

80. Leksell Gamma Knife ® CASE MIX 1991 - 2014 EUROPE 28.507 10.940 85.375 58.392 2.642 80 68-100% centers reporting 1991 reflects cumulative numbers

81. Leksell Gamma Knife ® INDICATIONS TREATED 1991 – 2014, EUROPE 81 * 68-100% centers reporting 1991 reflects cumulative numbers *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

82. Leksell Gamma Knife ® CASE MIX 2014 EUROPE 2.128 1.178 9.129 5.968 205 82 93% centers reporting

83. Leksell Gamma Knife ® OVER 22,000 PATIENTS TREATED THROUGH 2014 TURKEY 83 68-100% centers reporting

84. Leksell Gamma Knife ® CASE MIX 1997 - 2014 TURKEY 492 5.059 72 12.419 4.218 84 68-100% centers reporting

85. Leksell Gamma Knife ® OVER 22,000 PATIENTS TREATED THROUGH 2014 UNITED KINGDOM 85 68-100% centers reporting 1991 reflects cumulative numbers

86. Leksell Gamma Knife ® CASE MIX 1991 - 2014 UNITED KINGDOM 1.186 7.829 302 9.934 3.364 86 68-100% centers reporting 1991 reflects cumulative numbers

87. Middle East & Africa 1996 - 2014 PATIENTS TREATED WITH LEKSELL GAMMA KNIFE ® 87

88. 88 Leksell Gamma Knife ® OVER 17,000 PATIENTS TREATED THROUGH 2014 MIDDLE EAST & AFRICA 68-100% centers reporting

89. 89 Leksell Gamma Knife ® INDICATIONS TREATED ANNUALLY MIDDLE EAST & AFRICA 68-100% centers reporting

90. Leksell Gamma Knife ® CASE MIX 1996 - 2014 MIDDLE EAST & AFRICA 2.648 2.394 25 12.042 748 90 68-100% centers reporting

91. Leksell Gamma Knife ® CUMULATIVE INDICATIONS 1996 – 2014, MIDDLE EAST & AFRICA 91 * 68-100% centers reporting *Essential Tremor treatments reported as Other Functional Disorders prior to 2012

92. Leksell Gamma Knife ® CASE MIX 2014 MIDDLE EAST & AFRICA 494 349 5 1.962 140 92 88% centers reporting