1. Virology 1
PM2 Pathophysiology

2. Virus infectious particle DNA or RNA as its genetic material.
Needs to infect a host cell for replication
“toxic”, “poison”
virology
Tobacco mosaic virus

5. Baltimore classification of viruses
based on the mechanism of mRNA production.
I: dsDNA viruses
Adenoviruses, Herpesviruses, Poxviruses
II: ssDNA viruses (+)sense DNA
Parvoviruses
III: dsRNA viruses
Reoviruses
IV: (+)ssRNA viruses (+)sense RNA
Picornaviruses, Togaviruses
V: (-)ssRNA viruses (-)sense RNA
Orthomyxoviruses, Rhabdoviruses
VI: ssRNA-RT viruses (+)sense RNA :Retroviruses
VII: dsDNA-RT viruses :Hepadnaviruses

6. Icosahedral

7. Helical viruses
not grouped in capsomeres
ribbon-like structure        

8. Complex

10. Start

11. Forms of damage to the host cells
1. Cell lysis
2. Production of toxic substances
3. Cell transformation
4. Induction of formation of substances
5. Induction of structural alterations in the host cell ; Nuclear (including chromosomal) or Cytoplasmic changes

12. PRIONS Contain protein only small, proteinaceous particles Kuru
Creutzfeldt-Jakob disease syndrome

13. DNA VIRUSES Herpes Virus Hepatitis B virus Adenovirus Parvovirus
Polyomavirus
Papillomavirus

14. Herpesvirus herpes simplex virus type 1 herpes simplex virus type 2
varicella-zoster virus
Cytomegalovirus
Epstein-Barr virus
human herpesvirus 6
human herpesvirus 7
Kaposi's Sarcoma herpesvirus.

15. HSV
Causes encephalitis
DOC: Acyclovir

16. Varicella (chickenpox)

18. Herpes Zoster

19. CMV: 3 types of infections
1. Congenital cytomegalovirus infection
retinitis
petechial/purpuric skin rash
central nervous system defects
2. Mononucleosis syndrome
fever, malaise, atypical lymphocytosis, pharyngitis
3. immunocompromised individuals
life-threatening disease from either primary or reactivated infection

20. EBV
Epstein-Barr virus mononucleosis: most common that occurs in humans.
Infectious mononucleosis
Most cases: subclinical, (+) serology
Main cause of malignant B-cell lymphoma in organ transplants
PTLD:post-transplant lymphoproloferative disorder