1. XIX International AIDS Conference 25 July 2012 Lee Hall, MD, PhD Chief, Parasitology & International Programs Branch Division of Microbiology & Infectious Diseases

2. Interactions Between NTDs & HIV Are Bidirectional 2 Neglected Tropical Diseases HIV

3. Some Potential Effects of NTD-HIV Coinfections  Changes in Disease Progression or Clinical Manifestations  Changes in Transmissibility  Changes in Susceptibility  Impacts on Diagnostic Sensitivity or Specificity 3

4. Some Potential Effects of NTD-HIV Coinfections: Research Considerations  Qualitative vs. Quantitative Changes?  What Mechanisms Are Responsible for the Changes?  Are the Changes Reversible? Preventable?  What Would Be Considered a Meaningful Effect?  Do We Have Adequate Tools to Reverse or Prevent Changes?  What Alternatives Are Available to Achieve the Desired Changes? 4

5. Research Opportunities: Funding Mechanisms  Investigator-Initiated Research Projects –R01 Research Project Grant –R03 Small Grant –R21 Exploratory/Developmental Grant Clinical Trials –R34 Clinical Trial Planning Grant –U01 Clinical Trial Implementation Grant –mR01 Milestone-driven Clinical Trial Implementation Grant  Solicited Research Activities See NIAID Home Page (www.niaid.nih.gov) for Funding Opportunity Announcements  Research Resources 5

6. 6

7. Research Opportunities: Examples of Research Resources  Filariasis Research Reagent Resource Center (FR3)  Schistosomiasis Resource Center  International Collaborative Network for the Study of Human Helminth Co-infections  HIV/AIDS Clinical Trials Networks 7

8. For More Information: www.niaid.nih.gov  NIAID Home Page 8

9. 9