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Neurological Disorders
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During this presentation we will cover…
Huntington’s Encephalitis Menegitis Alzheimer’s Parkinsons Spina Bifita Tourette’s Prions/Crutchfield Jacob’s Epilepsy Concussions Stroke Brain Cancer Mononeuropathy Polyneuropathy
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Huntington’s Disease A genetic disease that causes degeneration of brain cells in certain areas of the brain, it is also known as Huntington’s Chorea It can only be transmitted genetically Early symptoms are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision Later symptoms are intellectual tasks become increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing.
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Huntington’s Disease There is no cure for Huntington’s
Treatments are meant to lessen the symptoms of mental instability, pain, and depression Length of the disease and progression varies from person to person Can be diagnosed through symtoms, CT, PET, and MRI scans Can be diagnosed through genetic screening, if you have Hungtion’s your children have a 50% chance of getting the disease
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Huntington’s Disease
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Encephalitis The inflammation of the brain, most often caused by viral infections Elderly and young children/babies are more likely to get the disease As the brain tissue swells, nerves may become damaged and bleeding can occur, both of these can lead to permanent brain damage
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Encephalitis Initial/early symptoms of the disease resemble that of the flu Severe/emergency symptoms include loss of consciousness, seizure, sudden mental impairment It is treated with antivirals, antibiotics, anti-seizure medication, sedatives and steroids
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Encephalitis
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Meningitis It is the inflammation of the membranes that cover the brain and spinal chord The viral version is less severe than the bacterial version The bacterial version is preventable through the meningitis vaccine
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Meningitis Some minor symptoms can come across as flu like: fever/chills, vomiting, stiff neck and headache Severe symptoms include rapid breathing, loss of consciousness, agitation, and strange posture Meningitis can result in death or permanent brain damage if not treated soon enough with antibiotics, IV fluid, and steroids.
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Meningitis
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Alzheimer’s It is a type of dementia that causes problems with memory, thinking, and behavior. It is the most common form of dementia It is a progressive disease, so symptoms get worse over time It is not a normal part of aging It can onset as early as the 40’s but most commonly appears in the late 60’s or early 70’s of an individual
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Alzheimer’s Results in the continual degeneration and death of brain cells The primary cause of it is uncertain. Scientists do know it is a combination of genetics, lifestyle, and environment. Risk Factors: Age, Family History, Female gender, Cognitive Impairment, Activity Level (both physical and mental), Smoking, Heart health
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Alzheimer’s There is no cure for Alzheimer’s at this time, doctors can prescribe drugs that boost brain cell communication but this is only effective in the initial stages of the disease. Death will occur eventually 1 in 85 is predicted to have Alzheimers Is diagnosed through symptoms, CT, MRI, and PET scans
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Alzheimer’s
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Parkinson’s It is a motor system disorder
It is caused by the loss of dopamine producing brain cells Results in loss of muscle control Common symptoms of this are: tremor, impaired balance, stiffness, lack of coordination in movements, trouble speaking
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Parkinson’s Scientists unsure of direct cause of damage to dopamine producing brain cells Stress, physical damage, gender, exposure to toxins and genetics all are contributing factors Seen in 1% of the population that is over 60 and 4% of the population that is over 80 Usually diagnosed through symptoms and MRI Can be treated with surgery, physical therapy, and medication (things that are converted to dopamine or mimic it)
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Parkinson’s Does not necessarily lead to death
Famous people with Parkinsons Michael J. Fox, Muhammed Ali, Billy Kennedy, Billy Graham
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Spina Bifida It is a birth defect in which the backbone and spinal canal do not close before birth Can be mild or severe Mild form, which is most common, cannot be detected without X-ray and does not create problems Severe form has two types Meningocele, fluid leaks out of spine and pushes against skin Myelomeningocele, most severe, nerves push out of spine and become damaged. Creates problems with walking, bowel/bladder control, learning disabilities and muscle coordination
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Spina Bifida Cause is unknown, Genes and birth history play a role. Mother’s health plays contributes towards likelihood. Individuals with it can have a normal life, 10% of the population has the mild form of the disease. Individuals with the most severe form of the disease have the ability to live up to with modern medicine
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Spina Bifida Treatments can range from surgery, orthotics, physical/occupational therapy, catheterization
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Tourette’s a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics most people with the condition experience their worst tic symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood
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Tourette’s The direct cause of the disorder, it effects multiple regions of the brain which use multiple types of neurotransmitters. Genetics due play a contributing role. Neuroleptics, stimulants, and blood pressure medication can be used to alleviate some of the tics
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Prion’s / Creutzfeldt Jakob’s
Prions are proteins, when they take on an infectious form they clump together and attack brain tissue Creutzfeldt Jakob’s disease is where through bacterial or viral infection prions convert to an infectious form and attack the brain. Believed to be caused by a slow virus or another organism, but scientists have yet to find it. 5-10% of the cases are genetic
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Prion’s / Creutzfeldt Jakob’s
Mad Cow, also known as Bovine Spongiform Encephalitis was considered a variant form of Creutzfeldt Jakob’s, but their prions while both infectious were slightly different Kuru is another version of spongiform encephalopathy where after consuming brain tissue of an individual with the disease the consumers prions become infectious and attack the brain
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Prion’s / Creutzfeldt Jakob’s
Diagnosed through symptoms and ruling out all other causes of mental instability. Only true way to diagnose as specifically Prion’s / Creutzfeldt Jakob’s is through autopsy Symptoms include progressive dementia: muscle coordination, personality change, impaired memory/judgement, muscle jerks and blindness. Always will result in death
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Prion’s / Creutzfeldt Jakob’s
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Prion’s / Creutzfeldt Jakob’s
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Epilepsy Epilepsy is a brain disorder in which a person has repeated seizures (convulsions) over time. Epilepsy occurs when permanent changes in brain tissue cause the brain to be too excitable or jumpy. Causes: Stroke, Dementia, Brain Injury, HIV, AIDS, Congenital Birth Defects, Metabolism, Brain Tumor, Abnormal Brain Blood Vessels, Illnesses that damage or destroy brain tissue.
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Epilepsy Some people may have simple staring spells, while others have violent shaking and loss of alertness Seizure types Absence seizure: prolonged staring Grand Mal seizure: convulsions and shaking of body Partial seizure: part of the brain becomes unresponsive
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Epilepsy Can be diagnosed through EEG, blood chemistry, blood count, liver function test, kidney function test, lumbar function test, CT scan, MRI Treatment can be anti-seizure medication, surgery to remove brain cells or repair abnormal blood vessels, implantation of VNS
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Epilepsy Can live a normal lifespan with condition, if not caused by a more severe disease Symptoms normally lessen with age and treatment
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Concussions Concussions are considered to be any traumatic brain injury that alters the way the brain functions. Effects are most often temporary, but repeated concussions will lead to permanent brain damage
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Concussions Signs and symptoms a concussion may have occurred Headache
Loss of consciousness Confusion Amnesia on the event that caused the injury Dizziness Ringing in ears Nausea and vomiting Slurred speech Tiredness/Fatigue
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Concussions What occurs in a concussion is the brain accelerates into the wall of the skull rapidly resulting in it hitting the skull To diagnose a concussion doctors will give you a neurological exam to test memory/coordination, vision, hearing, strength/sensation, balance, coordination, reflexes CT scan Observation
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Concussions Repeated concussions can result in Epilepsy
Progressive cognitive impairment Second Impact Syndrome
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Stroke A stroke is when the blood supply to the brain is interrupted or reduced. This deprives the brain of oxygen and nutrients, which in turn kills brain cells. Signs that someone is having a stroke or has just had one Trouble walking Trouble speaking or understanding Paralysis or numbness on one side of the body/face Trouble seeing in one or both eyes Headache
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Stroke There are two main types of stroke Ischemic and Hemorrhagic
Ischemic-makes up for 90% of strokes, can be thrombotic when a clot forms in one of the arteries that supplies blood to the brain or embolic when a clot occurs in a blood vessel away from the brain usually the heart, blood ends up pooling and not getting to the brain
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Stroke Hemorrhagic-occurs when blood vessel leaks or ruptures, can occur inside the brain (intracerebral) or on the surface of the brain (subarachnoid) Risk factors for stroke- family history, 55+, High B.P., High Cholesterol, smoking, diabetes, being overweight/obese, physical inactivity, heart disease, hormone medication, binge drinking, use of cocaine or methamphetamines
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Stroke Strokes will not lead to death but can lead to permanent or temporary brain damage Paralysis Difficulty walking/talking/understanding Pain Change in Behavior and Self Care (Physical and occupational therapy will help improve the above complications
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Brain Cancer Mass of abnormal cells growing in/on brain
Can be benign or malignant Some growths start in brain, others spread from spine/other parts of body
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Brain Cancer 9 types of brain cancer
Infiltrative astrocytoma Pilocytic astrocytoma Oligodendroglioma Mixed oligoastrocytoma Glioblastoma multiforme Ependymoma Medulloblastoma Meningioma Infiltrative astrocytoma and glioblastoma multiforme (GBM) account for nearly 85% of all brain tumors
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Brain Cancer SYMPTOMS OF BRAIN TUMORS
Frequent headaches that are more painful when lying down Vomiting, with or without nausea Blurred or double vision Seizures Impaired thinking, mental confusion, or even coma
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Brain Cancer Diagnosed through CT, PET or MRI scans; spinal tap, biopsy, Electroencephalograph, or Cerebral arteriograph Brain cancer is treated with radiation, surgery, chemotherapy, steroids, and anti-convulsant medication People can survive brain cancer depending on the tumor type and how soon it is treated, but it also can result in death even if treatment occurs.
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Mononeuropathy Mononeuropathy is a type of damage to nerves outside the brain and spinal cord Mononeuropathy is most often caused by injury, although body-wide disorders may cause isolated nerve damage. Long-term pressure on a nerve due to swelling or injury can result in mononeuropathy
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Mononeuropathy Symptoms depend on the specific nerve affected, and may include: Loss of sensation Paralysis Tingling, burning, pain, abnormal sensations Weakness
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Mononeuropathy Is diagnosed through EMG, nerve conduction test, nerve biopsy, MRI, CT Scan, thyroid test, blood test, Treated with physical therapy, occupational therapy, medication, orthothics, Mononeuropathy can result in permanent pain, loss of movement or sensation
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Polyneuropathy Polyneuropathy is a condition where nerve damage affects several areas The nerve damage results from either poor blood supply to the area or abnormal functioning of the nerve Diabetes is the major cause of chronic polyneuropathy, also result from old age, certain drugs, AIDS, and alcoholism.
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Polyneuropathy Symptoms depend on the specific nerve affected, and may include: Loss of sensation Paralysis Tingling, burning, pain, abnormal sensations Weakness
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Polyneuropathy Is diagnosed through EMG, nerve conduction test, nerve biopsy, MRI, CT Scan, thyroid test, blood test, Treated with physical therapy, occupational therapy, medication, orthothics, vitamin treatment Polyneuropathy can result in permanent pain, loss of movement or sensation
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