1. -19.03.9hypothetical protein LOC554226LOC554226237794_at -8.33.9neurotrophic tyrosine kinase, receptor, type 3NTRK3206462_s_at -2.73.9nuclear receptor subfamily 6, group A, member 1NR6A1242724_x_at -12.94.0C1q and tumor necrosis factor related protein 3C1QTNF3237634_at -3.64.0Full length insert cDNA YN57B01no information1556777_a_at -4.34.1storkhead box 2STOX2231969_at -4.94.2 Transcribed locus, strongly similar to NP_061844.1 G protein-coupled receptor 27;super conserved receptor expressed in brain 1 [Homo sapiens] no information227769_at -2.44.8zinc finger protein 403ZNF403233937_at -3.05.0four and a half LIM domains 1FHL1201539_s_at -3.65.3hypothetical protein FLJ23861FLJ238611558595_at -3.55.4interleukin 1 receptor-like 1IL1RL1234066_at -2.26.0endothelin receptor type BEDNRB204271_s_at -5.76.1exostoses (multiple) 1EXT11562863_at -2.26.8FAT tumor suppressor homolog 4 (Drosophila)FAT4219427_at -3.26.9CDNA FLJ34880 fis, clone NT2NE2015885no information1557647_a_at -2.17.0sorbin and SH3 domain containing 2SORBS2233720_at -4.57.2 solute carrier family 2 (facilitated glucose transporter), member 3 SLC2A3202499_s_at -2.07.5tissue factor pathway inhibitor 2TFPI2209278_s_at -2.68.6receptor tyrosine kinase-like orphan receptor 1ROR1231142_at -13.79.1forkhead box P2FOXP21555516_at -2.19.5CDNA FLJ36837 fis, clone ASTRO2011422no information227383_at -2.89.5 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I ADCYAP1R1226690_at -5.610.2chemokine (C-X-C motif) receptor 4CXCR4217028_at -2.410.5tissue factor pathway inhibitor 2TFPI2209277_at -2.211.6WWC family member 3WWC3225273_at -2.412.5GPI deacylasePGAP1233479_at -19.313.7sprouty-related, EVH1 domain containing 1SPRED1233465_at -47.226.9 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) ELAVL4234904_x_at -3.035.2 potassium inwardly-rectifying channel, subfamily J, member 2 KCNJ2206765_at -14.248.9dachshund homolog 2 (Drosophila)DACH2239738_at CFPAC-1 shPAUF Panc-1 PAUF Gene TitleGene SymbolProbe ID Supplementary Table 1. List of upregulated genes by PAUF *

2. -3.62.5activating transcription factor 6ATF6241240_at -4.32.5hypothetical protein FLJ10213FLJ10213219906_at -9.02.6hydroxysteroid (17-beta) dehydrogenase 12HSD17B121557252_at -3.02.6chloride intracellular channel 6CLIC6242913_at -3.62.6no information 234082_at -3.12.6hypothetical gene CG012CG012215318_at -3.62.6mucolipin 3MCOLN3220484_at -8.22.6hypothetical gene supported by BX647608LOC399959233364_s_at -2.02.7palladin, cytoskeletal associated proteinPALLD200906_s_at -2.32.8cyclin-dependent kinase 6CDK6224848_at -2.22.8stearoyl-CoA desaturase 5SCD5224901_at -3.22.8thymus high mobility group box protein TOXTOX204530_s_at -3.92.9RAN binding protein 17RANBP17234137_s_at -3.23.0deiodinase, iodothyronine, type IIDIO2231240_at -2.23.0WAS/WASL interacting protein family, member 1WIPF1202665_s_at -2.13.1zinc finger, MYND domain containing 11ZMYND11243054_at -2.43.2claudin domain containing 1CLDND1239146_at -31.53.2exostoses (multiple) 1EXT11564378_a_at -3.13.2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 SERPINA1211429_s_at -2.23.2hypothetical gene supported by BX647608LOC399959232113_at -2.23.2cyclin-dependent kinase 6CDK6207143_at -2.13.3WWC family member 3WWC3219520_s_at -3.73.3formin binding protein 1FNBP1244286_at -26.83.3DDHD domain containing 1DDHD1231165_at -2.63.3histone deacetylase 3HDAC3240482_at -3.93.3Transcribed locusno information231513_at -2.03.4lymphocyte antigen 96LY96206584_at -4.33.4WAS/WASL interacting protein family, member 1WIPF1202664_at -2.73.5carboxypeptidase MCPM235706_at -2.93.7SEC24 related gene family, member D (S. cerevisiae)SEC24D215209_at -2.23.8phosphodiesterase 4D interacting protein (myomegalin)PDE4DIP232615_at -2.73.8mitogen-activated protein kinase kinase kinase 8MAP3K8235421_at -15.43.8gap junction protein, alpha 10, 59kDaGJA10221415_s_at -8.13.9carboxypeptidase MCPM206100_at CFPAC-1 shPAUF Panc-1 PAUF Gene TitleGene SymbolProbe ID Supplementary Table 1 - continued

3. -2.12.1kelch-like 22 (Drosophila)KLHL22222141_at -32.62.1Fc receptor-like 5FCRL5224405_at -7.82.1no information 234704_at -2.32.1DBF4 homolog B (S. cerevisiae)DBF4B238757_at -3.02.1no information 208039_at -7.42.1regulatory factor X, 3 (influences HLA class II expression)RFX3207234_at -2.72.1sterile alpha motif domain containing 4ASAMD4A235756_at -2.32.1ring finger protein 34RNF34236288_at -3.52.1no information 1558732_at -2.72.2 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) MASP1210680_s_at -2.62.2suppressor of variegation 4-20 homolog 1 (Drosophila)SUV420H11565974_at -2.22.2 Full-length cDNA clone CL0BB018ZE07 of Neuroblastoma of Homo sapiens (human) no information41856_at -4.12.2no information 244755_at -3.22.2oxidized low density lipoprotein (lectin-like) receptor 1OLR1210004_at -2.72.2fibronectin type III domain containing 3BFNDC3B1569490_at -3.32.3RNA binding motif protein 41RBM41243673_at -3.02.3KIAA1128 1554131_at -4.62.3pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)PLRG1238137_at -2.12.3Homo sapiens, clone IMAGE:2960615, mRNAno information1569961_at -3.82.3 Transcribed locus, strongly similar to NP_002137.3 homeo box B3;homeo box 2G;homeobox protein Hox-B3 [Homo sapiens] no information237189_at -3.62.3zinc finger protein 545ZNF545235176_at -8.72.3GRB2-related adaptor proteinGRAP235102_x_at -3.52.3actin related protein 2/3 complex, subunit 5, 16kDaARPC51569325_at -2.52.4FGFR1 oncogene partner 2FGFR1OP21556282_at -9.32.4TDP-glucose 4,6-dehydrataseTGDS237346_at -2.22.4 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) EGFR211551_at -3.52.4 integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) ITGAV232797_at -3.12.4neuron navigator 1NAV1242986_at -8.62.5paired box gene 9PAX9231145_at -4.12.5acyl-CoA synthetase long-chain family member 4ACSL41557419_a_at CFPAC-1 shPAUF Panc-1 PAUF Gene TitleGene SymbolProbe ID Supplementary Table 1 - continued

4. -2.92.0CDNA FLJ37243 fis, clone BRAMY2004387no information228632_at -2.72.0PRO1496no information221155_x_at -2.82.0 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ICAM1202637_s_at -3.92.0ATP-binding cassette, sub-family G (WHITE), member 1ABCG1204567_s_at -8.92.0hypothetical protein LOC338653LOC3386531562960_at -2.02.0hypothetical protein LOC647946LOC647946240365_at -4.52.0CDNA clone IMAGE:5312582no information1557018_a_at -2.22.1CDNA clone IMAGE:4841343no information230672_at -2.82.1pentraxin-related gene, rapidly induced by IL-1 betaPTX3206157_at -2.92.1 integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) ITGAV241769_at CFPAC-1 shPAUF Panc-1 PAUF Gene TitleGene SymbolProbe ID Supplementary Table 1 - continued * List of 96 genes (104 fragments) expressed at levels more than two-fold higher in Panc- 1_PAUF than in Panc-1_Mock and more than twofold lower in CFPAC-1_shPAUF than in CFPAC-1_shCtrl.