1. A centre of expertise in digital information management www.ukoln.ac.uk UKOLN is supported by: Open Science at Genome Scale Dr Liz Lyon, Director, UKOLN, University of Bath, UK Associate Director, UK Digital Curation Centre Survive or Thrive Workshop, Manchester, June 2010. This work is licensed under a Creative Commons Licence Attribution-ShareAlike 2.0

2. 1.Scale, Complexity, Predictive Potential 2.Continuum of Openness 3.Citizen Science 4.Credentials, Incentives, Rewards 5.Institutional Readiness & Response 6.Data Informatics Capacity & Capability http://www.ukoln.ac.uk/ukoln/staff/e.j.lyon/publications.html#november-2009 Open Science at Web-Scale Consultation: Write-To-Reply Keynote Presentations: eResearch Australasia Nov 2009 CNI, Baltimore April 2010 http://www.ukoln.ac.uk/ukoln/staff/e.j.lyon/presentations.html

4. ...Next next generation technology race to market $1000 genome in <15 minutes....by 2013?

5. ...data deluge challenges.... Large-scale data storage that is: –Cost-effective (rent on-demand) –Secure (privacy and IPR) –Robust and resilient –Low entry barrier / ease-of-use –Has data-handling / transfer / analysis capability Move sequencing out of genome centres....analyse an entire human genome in a single day sitting with a laptop at your local Starbucks....cloud services?

6. Clients in the cloud

7. The new genome informatics ecosystem The case for cloud computing in genome informatics. Lincoln D Stein, May 2010

8. Data sets are becoming the new instruments of science

9. Post-genome decade Human genomes: >24 published & almost 200 unpublished

10. P4 medicine : Predictive, Personalised, Preventive, Participatory. Leroy Hood – Institute for Systems Biology Image from Scientific American...medicine is going to become an information science...

11. P4 medicine Each patients genome sequenced Your genome is basis of your medical record New method to anonymise medical records for genomics research at Vanderbilt Univ (April 10) New predictive models of health and disease Personalised treatments focus on preventative therapies Genome scale network biology Genomic data as a commodity

12. They have shared their data….

13. Share my data?

14. Sage Bionetworks : Integrative genomics Open data in the Sage Commons repository Human and mouse: clinical and genetics data Develop predictive models of disease: liver / breast / colon cancer, diabetes, obesity Crowd-sourced effort : global scope Stephen Friend

15. Participatory medicine : Empowering the patient... Sage Congress San Francisco April 2010

16. Calls for action, new metrics

17. How to cite large-scale predictive network models? Incentivise: get credit Attribution granularity Multiple data sources & standards Linked data approach Workflow integration Curate the data......

18. Human Genome printed http://www.flickr.com/photos/johnjobby/2252981353/sizes/l/ Discuss.... 1.Scaleable data infrastructure? 2.Personal genomics - share your data? 3.Transform 21stC medicine / bioscience? 4.Credit & attribution for data and models?