1. CReST Program Update

2. The Story… “One in a billion” – genomic medicine discovers the cause of a young boy’s disease Howard Jacobs, PhD Human Molecular Genetics Center, Medical College of Wisconsin X-linked Inhibitor of Apoptosis (XIAP) Cysteine-aspartic acid proteases (caspases) XIAP and initiator caspase 9  biochemistry: structure and protein interactions  genetics: effect of mutations in XIAP

3. How students approach the story… Fall semester: integrated into two courses Biochemistry (Heather Mernitz)  Previous CReST student introduced XIAP/caspase  Model system for core concepts  Capstone project: Student teams investigated one of three pathways in detail Genetics (Carl Ball)  Genomics of “One in a Billion”  Capstone project: One student team investigated an genetic disorder in XIAP gene Capstone: Public joint poster session

4. How students approach the story… Spring semester: independent study Tina Jesulin, Sara Klosiewski, Phaya Lem, Jessica Weiss Build on foundation from course work Goal: model illustrating XIAP function  Biochemical principles  Genetic variants Research XIAP literature Selected problem – see their poster