1. Metabolism Energy of Life

2. Metabolic Pathways Anabolic PathwaysCatabolic Pathways

3. Kinetic Energy

4. Potential Energy

5. First Law of Thermodynamics Energy can be transferred or transformed but it cannot be created or destroyed

6. Second Law of Thermodynamics Every energy transfer or transformation increases the entropy of the Universe

7. Free Energy Gibbs Equation  G =  H – T  S  G – Change in Free energy  H – Change in Total energy T – Absolute temperature in Kelvin  S – Change in Entropy

8. Free Energy and Metabolism

9. Exergonic Reactions Release of energy -G-G Spontaneous Downhill More energy in reactants than in products Ex. Cellular Respiration -686 kcal/mol Ex. ATP  ADP + P -7.3 kcal/mol Endergonic Reactions Absorbs energy +G+G Nonspontaneous Uphill More energy in products than in reactants Ex. Photosynthesis +686 kcal/mol Ex. ADP + P  ATP +7.3 kcal/mol

12. Enzymes Biological Catalyst Speed up metabolic reactions by lowering the energy of activation

14. Enzymes Substrate Specific Active Site Induced Fit Recycled

16. Enzymes Inhibitors Competitive Noncompetitive

17. Enzymes Allosteric Sites Cooperativity

18. Feedback Inhibition Pathway switched off