1. Translational Genomics Research Institute | www.tgen.org The Sarcoma Data Portal: Making High Content Sarcoma Datasets Available For All Users Jonathan Keats, PhD Translation Genomics Research Institute

2. Translational Genomics Research Institute | www.tgen.org Outline Some examples of other systems Outline of the initial concepts for the Sarcoma Portal

3. Translational Genomics Research Institute | www.tgen.org Myeloma Cell Line Portal - Query This project includes matched CGH, exome sequencing and RNA sequencing

4. Translational Genomics Research Institute | www.tgen.org Myeloma Cell Line Portal - Mutations

5. Translational Genomics Research Institute | www.tgen.org Myeloma Cell Line Portal - Expression

6. Translational Genomics Research Institute | www.tgen.org Multiple Myeloma Genomics Portal This supports a diverse collection of multiple datasets on multiple platforms

7. Translational Genomics Research Institute | www.tgen.org Multiple Myeloma Researcher Gateway

8. Translational Genomics Research Institute | www.tgen.org Sarcoma Portal Initial phase to focus on existing gene expression profiling datasets from large (>20) patient studies. – Preference for studies with overall survival or progression free survival The central design philosophy is to provide users with an easy way to interrogate datasets

9. Translational Genomics Research Institute | www.tgen.org Proposed General Layout

10. Translational Genomics Research Institute | www.tgen.org Kaplan-Meier Generation -Single Gene or Multiple Gene Analysis -Subset or Group Analysis -Multiple plot formats -Barplots (individual sample) -Box plots or dot plots (groups) -Histograms (dataset) -Kaplan-Meier (between groups) -Publication quality graphics -Experienced user recommendations

11. Translational Genomics Research Institute | www.tgen.org Suggestions are Welcome jkeats@tgen.org