1. Pb09207223 张馨元 Pb10206066 张希良 Pb10207016 高绪远 Nano-Dendrimers Used in Drug Delivery

2. Outline Why dendrimers? What is dendrimers? How it works? Cytotoxicity Conjecture

3. Structures for Drug Delivery Liner polymers Larger nanoparticles Liposomes http://www.sciencedirect.com/science/article/pii /S1740674905000107 http://trialx.com/curetalk/2012/10/nanotechnolo gy-drug-delivery-systems-an-insight/ https://sitn.hms.harvard.edu/sitnflash_wp/2011/0 6/materials-for-drug-delivery/

4. What is dendrimers? Dendrimers are used as well-de fi ned scaffolding or nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties.

5. What is dendrimers? http://www.nanotechnologies.qc.ca/projects/nanopatterning/nanopatterning

6. What is dendrimers? http://www.pharmainfo.net/reviews/dendrimer-overview

7. What is dendrimers? Anupa R. Menjoge et. al, Drug Discovery Today, 2010

9. How it works?

10. Cytotoxicity Concentration Generation Surface charge dependent

11. Conjecture

12. ?

13. Hybrid tree If we combine two of the branches of the core with some other small molecules which can be easily hydrolyzed to release the active site of the core…

14. Parrott, M. C.; Benhabbour, S. R.; Saab, C.; Lemon, J. A.; Parker, S.; Valliant, J. F.; Adronov, A. J. Am. Chem. Soc. 2009, 131, 2906-2916.

15. Sub-Hybrid Tree If we add some other surface molecules which can combine the pre- surface, When the generation is over 4…

16. New cocktail? We know that the release of physically entrapped guest-type drugs in dendrimeric hosts might be controlled by both surface modification and the density of modifying groups. Well, what can we do?

17. Thanks!