1. Coronary Phantom Design for K-edge Angiography John Jorgensen Sarah Pachtman Punam Patel Marcus Spallek Advisor: Dr. Frank Carroll

2. MXI Systems MX 200 –Applications Radiotherapy Crystallography Mammography Pediatrics K-edge Imaging –Angiography??? http://www.onlinetelemedicine.com/html/product/sa m_images/Angiography.jpg

3. Project Background Monochromatic tunable X-ray: –Reduced radiation dose to patient –Reduced contrast agent concentrations K-edge imaging FOR MORE INFO... Free Electron Laser Laboratory  http://www.vanderbilt.edu/fel/ Diagram of MX200’s laser paths and major elements. http://www.mxisystems.com/mx200.html

4. K-edge Effect

5. Project Goals Design a coronary phantom Test contrast agent concentrations –hypersensitivity reaction to iodine (3-12% patients) –current clinical dilution is 1:16 –using monochromatic plain films it is possible to see 1:256 dilutions Determine optimal angle for stereo imaging θ 30” 3” Tan θ = 3/30 = 0.10 θ ~ 6°

6. Solution Description Radio Translucent at 35 keV Flexible material –Fluid perfusion Phantom Size –7.5cm diameter Vasculature –Size Range 5 - 1 mm –Coronary arteries on surface –Curved channels –Hollow vessels Finger imaged at 19 keV Finger imaged at 26 keV

7. Phantom Designs Shelley Medical Imaging Technologies www.simutech.com Preliminary Sketch SolidWorks Model

8. Material Considerations Ideal Material –ReoFlex™ 20 polyurethane resin Actual Material –Z-Corp’s ZP 102 plaster-based powder –Compatible with printing machine used for prototyping process –Ideal for printing fine-detail or thin-walled models –Radiotranslucent and flexible formulation –Option to infiltrate with Synair Corporation Por-A-Mold polyurethane resin

9. Schedule FOR MORE INFO... http://vubme.vuse.vanderbilt.edu/srdesign/2003/group12/NCIIA %20Grant%20Proposal.htm November December January February MarchApril Research Material Testing & Design Manufacturing Testing

10. Current Status Work Completed –Design Finalized –Manufacturer Contacted –Prototype Being Made Expected by Early Next Week

11. Future Plans April –Create Pump for Dosimetry Testing –Start Testing Test Dosimetry for Imaging Test for Optimal Stereo Angle –Write Final Report –Create Poster

12. Testing Create Pump for Dosimetry Testing Run Tests –Test Dosimetry for Imaging Acquire series of images with different dilutions of contrast agent –Test for Optimal Stereo Angle Acquire series of images at different rotation angles

13. Team and Resources Advisor: Dr. Frank Carroll, M.D. Monochromatic x-ray machine W.M. Keck Free-electron Laser (FEL) Center at Vanderbilt University Materials and tools provided by BME Department and FEL Center –Polyurethane resins from outside contractors Photograph of device with laser cover removed http://www.vanderbilt.edu/fel/Xray/manuscripts/final%20report%20for%20ONR%20grant%2020021218.doc

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