1. Eating Disorders Anorexia nervosa (AN) Less common Across all times & cultures Anxious, rigid, perfectionist traits High mortality & burden No leading treatment Poor outcomes Bulimia nervosa (BN) More common Western culture-bound Personality traits mixed CBT= leading treatment Most do not access CBT Binge Eating Disorder (BED) Very common Rising prevalence Epidemiology, Risk Factors & Prevention Neurobiology: Genetics, Neuroimaging, Neuropsychology, rTMS Psychological Treatments Better treatments for AN E-health Other Clinical Trials

2. Brain-Directed Treatment rTMS and Eating Disorders Background rTMS reduces food craving, bingeing and salivary cortisol in Bulimia Nervosa & Binge Eating Disorder Case series of patients with AN, giving one session of high-frequency rTMS applied to the left DLPF cortex: –Reduction in feeling full/fat & anxiety Uher et al., 2005; Claudino et al., 2010; Van den Eynde, et al., 2010; 2011a,b,c

3. E-health Interventions Online-CBT for BN in adolescents & adults significantly reduce symptoms On-line skills training for carers of people with AN significantly reduce carer distress & unhelpful behaviours (e.g. expressed emotion) On-line personality targeted prevention for common mental disorders in students ( PLUS-online )– in progress Schmidt, 2003; Murray et al., 2003; Barra-Carril et al., 2004; Schmidt et al., 2007; 2008; Pretorius et al., 2009; Grover et al., 2010; 2011; Sanchez-Ortiz et al., 2011a,b; Musiat et al., in preparation

4. Further Questions? Contact: Ulrike Schmidt Professor of Eating Disorders ulrike.schmidt@kcl.ac.uk