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William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 11 DNA Replication and Recombination Copyright © 2006.

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Presentation on theme: "William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 11 DNA Replication and Recombination Copyright © 2006."— Presentation transcript:

1 William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 11 DNA Replication and Recombination Copyright © 2006 Pearson Prentice Hall, Inc.

2 DNA Is Reproduced by Semiconservative Replication

3 Figure 11-1 Copyright © 2006 Pearson Prentice Hall, Inc.

4 Figure 11-2 Copyright © 2006 Pearson Prentice Hall, Inc. blue

5 DNA Is Reproduced by Semiconservative Replication The Meselson–Stahl Experiment

6 Figure 11-3 Copyright © 2006 Pearson Prentice Hall, Inc.

7 Figure 11-4 Copyright © 2006 Pearson Prentice Hall, Inc.

8 DNA Is Reproduced by Semiconservative Replication Semiconservative Replication in Eukaryotes

9 Figure 11-5a Copyright © 2006 Pearson Prentice Hall, Inc.

10 Figure 11-5b Copyright © 2006 Pearson Prentice Hall, Inc.

11 Figure 11-5c Copyright © 2006 Pearson Prentice Hall, Inc.

12 DNA Is Reproduced by Semiconservative Replication Origins, Forks, and Units of Replication

13 Figure 11-6 Copyright © 2006 Pearson Prentice Hall, Inc.

14 DNA Synthesis in Bacteria Involves Five Polymerases, as well as Other Enzymes DNA Polymerase I

15 Figure 11-7 Copyright © 2006 Pearson Prentice Hall, Inc.

16 Figure 11-8 Copyright © 2006 Pearson Prentice Hall, Inc.

17 Table 11-1 Copyright © 2006 Pearson Prentice Hall, Inc.

18 DNA Synthesis in Bacteria Involves Five Polymerases, as well as Other Enzymes Synthesis of Biologically Active DNA DNA Polymerase II, III, IV, and V

19 Table 11-2 Copyright © 2006 Pearson Prentice Hall, Inc.

20 Table 11-3 Copyright © 2006 Pearson Prentice Hall, Inc.

21 Many Complex Issues Must Be Resolved during DNA Replication

22 The DNA Helix Must Be Unwound

23 Figure 11-9 Copyright © 2006 Pearson Prentice Hall, Inc.

24 Initiation of DNA Synthesis Requires an RNA Primer

25 Figure 11-10 Copyright © 2006 Pearson Prentice Hall, Inc.

26 Antiparallel Strands Require Continuous and Discontinuous DNA Synthesis

27 Figure 11-11 Copyright © 2006 Pearson Prentice Hall, Inc.

28 Concurrent Synthesis Occurs on the Leading and Lagging Strands

29 Figure 11-12 Copyright © 2006 Pearson Prentice Hall, Inc.

30 Proofreading and Error Correction Are an Integral Part of DNA Replication

31 A Coherent Model Summarizes DNA Replication

32 Figure 11-13 Copyright © 2006 Pearson Prentice Hall, Inc.

33 Replication Is Controlled by a Variety of Genes

34 Table 11-4 Copyright © 2006 Pearson Prentice Hall, Inc.

35 Eukaryotic DNA Synthesis Is Similar to Synthesis in Prokaryotes, but More Complex Multiple Replication Origins

36 Figure 11-14 Copyright © 2006 Pearson Prentice Hall, Inc.

37 Eukaryotic DNA Synthesis Is Similar to Synthesis in Prokaryotes, but More Complex Eukaryotic DNA Polymerases

38 Figure 11-15 Copyright © 2006 Pearson Prentice Hall, Inc.

39 Table 11-5 Copyright © 2006 Pearson Prentice Hall, Inc. zeta

40

41 The Ends of Linear Chromosomes Are Problematic during Replication

42 Figure 11-16 Copyright © 2006 Pearson Prentice Hall, Inc.

43 Figure 11-17 Copyright © 2006 Pearson Prentice Hall, Inc.

44

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46 DNA Recombination, Like DNA Replication, Is Directed by Specific Enzymes

47 Figure 11-18 Copyright © 2006 Pearson Prentice Hall, Inc.

48 Figure 11-18a Copyright © 2006 Pearson Prentice Hall, Inc.

49 Figure 11-18b Copyright © 2006 Pearson Prentice Hall, Inc.

50 Figure 11-18c Copyright © 2006 Pearson Prentice Hall, Inc.

51 Figure 11-18d Copyright © 2006 Pearson Prentice Hall, Inc.

52 Figure 11-18f Copyright © 2006 Pearson Prentice Hall, Inc.

53 Figure 11-18g Copyright © 2006 Pearson Prentice Hall, Inc.

54 Figure 11-18h Copyright © 2006 Pearson Prentice Hall, Inc.

55 Figure 11-18i Copyright © 2006 Pearson Prentice Hall, Inc.

56 Gene Conversion Is a Consequence of DNA Recombination

57 Figure 11-19 Copyright © 2006 Pearson Prentice Hall, Inc.


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