1. Amphetamines Matthew Giannetti

2. Amphetamine Names Street Name: Co-pilots Speed Crank Dex Brand Name: Adderall Vyvanse Dexadrine Benzedrine in the past Chemical Name: alpha-methylphenethylamine

3. Drug Action Amphetamines modulate the neurotransmitters in the brain: dopamine serotonin norepinephrine Action happens in the nucleus accumbens, striatum, and prefrontal cortex. areas of the brain implicated in reward However, the action only takes place in specific places. Ex. Dompamine receptors in the hippocampus

4. Low DoseHigh Dose Drug Action

5. History & Medical Use January 18, 1887 Amphetamine is first synthesized at Universitat Berlin by Romanian chemist Lazar Edeleanu. 1930’s Amphetamine approved by AMA for sale in tablet form to treat narcolepsy and ADHD. 40’s & 50’s Amphetamine is distributed to troops in WWII and The Korean War

6. History & Medical Use cont. October 27, 1970 Injectable methamphetamine is named a Schedule II drug. Other amphetamines & non-injectable methamphetamine are named Schedule III drugs. July 7, 1971 Amphetamines and non-injectable methamphetamine are moved from Scdule III to Schedule II drugs. 1996 U.S. Congress passes act establishing new controls over key ingredients and strengthening criminal penalties for possession, distribution, and manufacturing

7. Amphetamine Derivatives

8. Physiological Effects of Amphetamines Clench/Grind teeth Rapid breathing Vasoconstriction Hyper and hypotension Hyperactivity and insomnia Diarrhea and/or constipation Tachycardia and Bradycardia Siezure, stroke, coma, heart attack, and death

9. Psychological Effects of Amphetamines Euphoria Sociability Self-esteem Anxiety and paranoia Irritability and agression Alterness and concentration Repetitive and obsessive behaviors

10. Possible Side Effects Depression Anxiety Increased appetite Agitation Vivid or lucid dreams Suicidal ideation

11. Bibliography "Erowid Amphetamine (Adderall) Vault." Erowid. 13 Jan. 2012. Web. 29 Feb. 2012.. "Methamphetamine." Home. Web. 29 Feb. 2012.. "Autonomic Pharmacology." Medical Pharmacology: Table_of_Contents. Web. 29 Feb. 2012.. "Amphetamines | CESAR." CESAR (Center for Substance Abuse Research). Web. 29 Feb. 2012.. "Important Facts About Amphetamine Abuse." Important Facts About Amphetamines: Main Line Health, Philadelphia, Pennsylvania. Web. 29 Feb. 2012..