1. European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership 19 July 2011 IAS 2011 Rome, Italy Charles S Mgone EDCTP Executive Director

2. About EDCTP Partnership between European member states, European Commission and Africa in collaboration with like minded organisations in fighting diseases of poverty – HIV/AIDS, malaria and tuberculosis This is realised by funding clinical trials and research capacity to accelerate development of intervention tools including drugs, vaccines, microbicides and diagnostics against these diseases

3. The partnership Benin Botswana Burkina Faso Cameroon Congo Cote d’Ivoire Democratic Republic of Congo Ethiopia Gabon Ghana Guinea Guinea-Bissau Guinea-Conakry Kenya Liberia Madagascar Malawi Mali Mozambique Namibia Nigeria Rwanda Senegal South Africa Sudan Tanzania The Gambia Togo Uganda Zambia Zimbabwe Austria Belgium Denmark France Germany Greece Ireland Italy Luxembourg Netherlands Norway Portugal Spain Sweden Switzerland United Kingdom EDCTP-EEIG member states Sub-Saharan African countries

4. Strengthening of clinical trials capacity and the enabling environment 1 2 3 4 5 6

5. EDCTP Regional Networks for Clinical Trials Western Africa: WANETAM Website: www.wanetam.org Project Coordinator: Prof. Soleymane Mboup Burkina Faso The Gambia Ghana Guinea-Bissau Mali Nigeria Senegal United States Southern Africa: TESA Website: www.tesafrica.org Project Coordinator: Dr Alexander Pym Botswana Malawi Mozambique South Africa Zambia Zimbabwe France Germany Netherlands United Kingdom Eastern Africa: EACCR Website: www.eaccr.org Project Coordinator: Dr Pontiano Kaleebu Kenya Sudan Ethiopia Tanzania Uganda Germany Sweden United Kingdom United States Central Africa: CANTAM Website: www.cantam.org Project Coordinator: Prof. Francine Ntoumi Cameroon Congo, Republic of the Gabon France Germany

6. Funded projects including clinical trials 2003-2011 Treatments 13 Vaccines9 Microbicides4 HIV/AIDS 26 clinical trials 108.30 M € Treatments7 Vaccines7 Diagnostics4 Tuberculosis 18 clinical trials 103.33 M € Treatments 10 Vaccines 2 Malaria 12 clinical trials 69.63 M € EDCTP has funded 174 projects in 29 African countries including 56 clinical trials on HIV/AIDS, malaria and TB

7. HIV/AIDS treatment and prevention trials Evaluation of paediatric formulations: fixed drug combinations/scored dispersible tablets Evaluation of second-line treatment HIV/TB co-infections Prevention of Mother to Child Transmission of HIV (PMTCT)

8. HIV preventive vaccine trials Capacity building in preparation for HIV vaccine trials- Joint EDCTP/BMGF grant DNA+MVA-CMDR (rgp 140/GLA-AF) phase I/II clinical trial (TaMoVac + AfrEVacc) in healthy young adults DNA + MVA-HIVA phase I/II in healthy infants born to HIV1 and HIV2 uninfected and infected mothers

9. Microbicide trials Site preparation/capacity strengthening Establishment of cohorts Characterisation of novel safety markers PRO 2000 vaginal gel phase III clinical trial

10. EDCTP-II Consolidation of the current focus on clinical trials Phase II and III clinical trials Expansion to phase I and IV clinical trials Health services/optimisation studies Neglected Tropical Diseases including co-morbidities Open collaborative projects with other developing countries beyond sub-Saharan Africa

11. Thank you http://www.edctp.org