1. Copyright © 2009 Pearson Education, Inc. Art and Photos in PowerPoint ® Concepts of Genetics Ninth Edition Klug, Cummings, Spencer, Palladino Chapter 20 Cell Cycle Regulation and Cancer Copyright © 2009 Pearson Education, Inc.

2. 20.1Cancer Is a Genetic Disease That Arises at the Level of Somatic Cells

3. Copyright © 2009 Pearson Education, Inc. Table 20.1

4. Copyright © 2009 Pearson Education, Inc. Figure 20.1

5. Copyright © 2009 Pearson Education, Inc. Figure 20.1a

6. Copyright © 2009 Pearson Education, Inc. Figure 20.1b

7. Copyright © 2009 Pearson Education, Inc. 20.1Cancer Is a Genetic Disease 20.1.1What Is Cancer? 20.1.2The Clonal Origin of Cancer Cells 20.1.3Cancer As a Multistep Process, Requiring Multiple Mutations

8. Copyright © 2009 Pearson Education, Inc. www.stemline.com/images/cscLarge.gif

9. Copyright © 2009 Pearson Education, Inc. Figure 18-2 Copyright © 2006 Pearson Prentice Hall, Inc.

10. Copyright © 2009 Pearson Education, Inc. 20.2Cancer Cells Contain Genetic Defects Affecting Genomic Stability, DNA Repair and Chromatin Modifications 20.2.1Genomic Instability and Defective DNA Repair

11. Copyright © 2009 Pearson Education, Inc. Figure 20.2a

12. Copyright © 2009 Pearson Education, Inc. Figure 20.2b Homogeneous

13. Copyright © 2009 Pearson Education, Inc. Figure 20.3

14. Copyright © 2009 Pearson Education, Inc.

16. Thursday, November 6, 2008 Scientists Decode Set of Cancer Genes By DENISE GRADYDENISE GRADY Published: November 5, 2008 For the first time, researchers have decoded all the genes of a person with cancer and found a set of mutations that may have caused the disease or aided its progression. Using cells donated by a woman in her 50s who died of leukemia, the scientists sequenced all the DNA from her cancer cells and compared it to the DNA from her own normal, healthy skin cells. Then, they zeroed in on 10 mutations that occurred only in the cancer cells, apparently spurring abnormal growth, preventing the cells from suppressing that growth and enabling them to fight off chemotherapy.cancer chemotherapy

17. Copyright © 2009 Pearson Education, Inc. NYTimes article on new teatment Link:

18. Copyright © 2009 Pearson Education, Inc. Figure 20.4 HNPCC- Hereditary Nonpolyposis Colorectal Cancer

19. Copyright © 2009 Pearson Education, Inc. 20.2Cancer Cells Contain Genetic Defects Affecting Genomic Stability, DNA Repair and Chromatin Modifications 20.2.2Chromatin Modifications and Cancer Epigenetics

20. Copyright © 2009 Pearson Education, Inc. 20.3Cancer Cells Contain Genetic Defects Affecting Cell-Cycle Regulation 20.3.1The Cell Cycle and Signal Transduction 20.3.2Cell Cycle Control and Checkpoints

21. Copyright © 2009 Pearson Education, Inc. Figure 20.5

22. Copyright © 2009 Pearson Education, Inc. Figure 20.6

23. Copyright © 2009 Pearson Education, Inc. Figure 20.7

24. Copyright © 2009 Pearson Education, Inc. 20.3Cancer Cells Contain Genetic Defects Affecting Cell-Cycle Regulation 20.2.3Control of Apoptosis

25. Copyright © 2009 Pearson Education, Inc. Figure 20.8

26. Copyright © 2009 Pearson Education, Inc. 20.4Many Cancer-Causing Genes Disrupt Control of the Cell Cycle

27. Copyright © 2009 Pearson Education, Inc. Table 20.2

28. Copyright © 2009 Pearson Education, Inc. 20.4Many Cancer-Causing Genes Disrupt Control of the Cell Cycle 20.4.1The ras Proto-oncogenes

29. Copyright © 2009 Pearson Education, Inc. Figure 20.9

30. Copyright © 2009 Pearson Education, Inc. Figure 18-12 Copyright © 2006 Pearson Prentice Hall, Inc.

31. Copyright © 2009 Pearson Education, Inc. 20.4Many Cancer-Causing Genes Disrupt Control of the Cell Cycle 20.4.2The cyclin D1 and cyclin E Proto-oncogenes 20.4.3The p53 Tumor-Suppressor Gene The “guardian of the genome” 20.4.4The RB1 Tumor-Suppressor Gene

32. Copyright © 2009 Pearson Education, Inc. Figure 20.10

33. Copyright © 2009 Pearson Education, Inc. Figure 20.11

34. Copyright © 2009 Pearson Education, Inc. 20.5Cancer Cells Metastasize, Invading Other Tissues

35. Copyright © 2009 Pearson Education, Inc. 20.6Predisposition to Some Cancers Can Be Inherited

36. Copyright © 2009 Pearson Education, Inc. Table 20.3

37. Copyright © 2009 Pearson Education, Inc. Figure 20.12

38. Copyright © 2009 Pearson Education, Inc. But…cancers can vanish on their own

39. Copyright © 2009 Pearson Education, Inc. 20.7Viruses Contribute to Cancer in Both Humans and Animals

40. Copyright © 2009 Pearson Education, Inc. Figure 20.13

41. Copyright © 2009 Pearson Education, Inc. Table 20.4

42. Copyright © 2009 Pearson Education, Inc. 20.8Environmental Agents Contribute to Human Cancers

43. Copyright © 2009 Pearson Education, Inc. Obesity responsible for 100,000 cancer cases annually By Matt Sloane, CNN Medical News November 5, 2009 5:58 p.m. EST http://www.cnn.com/2009/HEALTH/11/05/obesity.cancer.link/

44. Copyright © 2009 Pearson Education, Inc.