1. Female Genital Tract I, Case 3
Patient is a 69 year-old woman who presents with intermittent vaginal bleeding of 9 months duration.
Bimanual exam reveals a symmetrically enlarged, non-tender uterus.

2. Identify the organ
Describe the gross findings

3. Endometrial
cavity
Tumor
Myometrium
Uterus – endometrial cavity
A diffuse tumor involves the entire endometrial surface

4. Identify the organ
Identify the structures
Describe the gross findings

5. A – Endometrial Cavity
B – Endocervical Canal
C - Ectocervix
Endometrial Adenocarcinoma
The surgical specimen consists of the entire uterus, right ovary, and fallopian tube.
The uterus is opened along the anterior midline. A polypoid carcinoma (arrow)
is present in the upper left corner of the endometrial cavity.
Note that the remainder of the cavity is lined by flat, normal epithelium.

6. Endometrial Adenocarcinoma
A close-up view of the endometrial cavity reveals a polypoid carcinoma (arrow).
The mucosa lining the remainder of the cavity is normal.
A = Myometrium

7. Endometrial biopsy - Describe the histologic findings
Microscopic section of the endometrium reveals an adenocarcinoma.
The neoplasm is composed of well differentiated glands
which are "back to back". Very little stroma exists between the glands.
The glands are lined by multilayered, atypical epithelium.
Numerous mitoses (arrows) are present.