1. DOE SUPPORT OF NUCLEAR MEDICINE RESEARCH Alan B. Packard, Ph.D. Vice President Radiopharmaceutical Sciences Council Society of Nuclear Medicine

2. What is the Society of Nuclear Medicine (SNM)? The SNM is an international society established in 1954The SNM is an international society established in 1954 Serves >16,000 members including physicians, scientists, and technologistsServes >16,000 members including physicians, scientists, and technologists Promotes research and education in diagnostic and therapeutic applications of radionuclidesPromotes research and education in diagnostic and therapeutic applications of radionuclides Fosters basic research in Molecular ImagingFosters basic research in Molecular Imaging Facilitates 16M Nuclear Medicine procedures each year in the U.S. for the management of patients in oncology, cardiology, and neurologyFacilitates 16M Nuclear Medicine procedures each year in the U.S. for the management of patients in oncology, cardiology, and neurology

3. Directives and the Role of DOE Atomic Energy Commission (AEC) was established to explore “Atoms for Peace”Atomic Energy Commission (AEC) was established to explore “Atoms for Peace” AEC (now DOE) has supplied radionuclides for peaceful applications since 1946AEC (now DOE) has supplied radionuclides for peaceful applications since 1946 AEC was authorized and directed to promote research activities in the development of medical and biological applications of radionuclidesAEC was authorized and directed to promote research activities in the development of medical and biological applications of radionuclides

4. Highlights of Nuclear Medicine Research Supported by DOE (I) 1946Rectilinear Scanner (UCLA)1946Rectilinear Scanner (UCLA) 1958 99 Mo/ 99m Tc Generator (BNL)1958 99 Mo/ 99m Tc Generator (BNL) 1959 Gamma Camera (Donner Lab, LBNL)1959 Gamma Camera (Donner Lab, LBNL) 1970smIBG development (U. of Michigan)1970smIBG development (U. of Michigan) 1970sPET (Wash. U., U. of Penn., UCLA)1970sPET (Wash. U., U. of Penn., UCLA) 1976[ 18 F]FDG synthesis (BNL)1976[ 18 F]FDG synthesis (BNL) 1978PET with BGO (UCLA)1978PET with BGO (UCLA)

5. Highlights of Nuclear Medicine Research Supported by DOE (II) 1988 99m Tc-MIBI – myocardial perfusion agent (MIT, HMS)1988 99m Tc-MIBI – myocardial perfusion agent (MIT, HMS) 1990sMicro PET (UCLA)1990sMicro PET (UCLA) 1990sPET-receptor gene imaging (UCLA)1990sPET-receptor gene imaging (UCLA) 1990sPET tracers for drug addiction (BNL)1990sPET tracers for drug addiction (BNL) 1990s PET for diagnosis of oncologic, cardiologic, and neurological diseases1990s PET for diagnosis of oncologic, cardiologic, and neurological diseases

6. Highlights of Nuclear Medicine Research Supported by DOE (III) 1990sEstrogen receptor imaging (Wash. U., U. of IL)1990sEstrogen receptor imaging (Wash. U., U. of IL) 1990s Radiolabeled antibodies for therapy1990s Radiolabeled antibodies for therapy 1990sAntibodies for imaging infection1990sAntibodies for imaging infection 1990s  -emitting radionuclides for therapy1990s  -emitting radionuclides for therapy 2000PET studies for accurate assessment2000PET studies for accurate assessment of therapeutic intervention 2000PET imaging of gene expression2000PET imaging of gene expression

7. AEC’s “Atoms for Peace” Legacy The funding has: Supported basic research in physics and chemistry of Nuclear ImagingSupported basic research in physics and chemistry of Nuclear Imaging Funded development and innovations in equipment of Nuclear and Molecular ImagingFunded development and innovations in equipment of Nuclear and Molecular Imaging Accelerated translational research from bench to clinical applicationsAccelerated translational research from bench to clinical applications Generated outstanding leading researchers in Nuclear Medicine and Molecular ImagingGenerated outstanding leading researchers in Nuclear Medicine and Molecular Imaging

8. Basic and Translational Research and Development Grants (2004) Individual Investigators grants -44Individual Investigators grants -44 National Lab. Multi-Investigators projects -25National Lab. Multi-Investigators projects -25 SBIR GrantsSBIR Grants –Phase I 8 –Phase II 8 Total85

10. Effects of Program Termination Weakening of the leadership position of the U.S. in “Atoms for Medical Use” and “Bench-to-Bedside” programsWeakening of the leadership position of the U.S. in “Atoms for Medical Use” and “Bench-to-Bedside” programs Challenging the productivity and creativity of NM professionalsChallenging the productivity and creativity of NM professionals Slowing advances in a highly innovative branch of medicineSlowing advances in a highly innovative branch of medicine Delaying improvements in patient careDelaying improvements in patient care Impeding the development of outstanding scientists in the fieldImpeding the development of outstanding scientists in the field

11. Importance of Continued Funding These severe consequences can be avoided only by the continuation of this program, which supports basic research in “Nuclear Medicine” that is not funded by other mechanismsThese severe consequences can be avoided only by the continuation of this program, which supports basic research in “Nuclear Medicine” that is not funded by other mechanisms Therefore, on behalf of the >16,000 members of the SNM, I urge the nation’s leaders not to terminate this vitally important fundingTherefore, on behalf of the >16,000 members of the SNM, I urge the nation’s leaders not to terminate this vitally important funding