1. Effects of exercise on the respiratory system. Dr Abdulrahman Alhowikan Collage of medicine Physiology Dep.

2. Aims By the end of this lecture the students should be able to:  Understand the difference between dynamic and isometric exercise.  Describe the effects of moderate and severe exercise on oxygen consumption (Vo 2 Max), and ventilation volumes.  Describe the effects of exercise on arterial PO2, PCO2 and H+ ions.  Define the diffusing capacity of the respiratory membrane, and its typical values at rest, and explain its changes in exercise.  Explain causes of hyperventilation in exercise.

3. the difference between dynamic and isometric exercise  isometric exercise not shorten during  Muscle contraction is said to be isometric (static) when the muscle does not shorten during contraction length of the muscle does not change  static strength training, involve muscular actions in which the length of the muscle does not change and there is no visible movement at the joint eg Pushing wall  strengthening the muscles without stress  strengthening the muscles without stress on the joint eg in rehabilitation Valsalva-Maneuver  drives up blood pressure and Valsalva-Maneuver  static strength required to stabilize the upper and lower body

4. the difference between dynamic and isometric exercise cont…  dynamic exercise full rang of motion  dynamic exercises increase strength throughout the full rang of motion endurance are improved  Blood circulation, strength, and endurance are improved by these continuous movements  Eg. swimming, walking

5. effects of moderate and severe exercise on oxygen consumption, and ventilation volumes. 250 ml/min.  Normal oxygen consumption (Vo2 Max) for a young man at rest is about 250 ml/min.  However, under maximal conditions!  Untrained average male 3600ml/min  Athletically trained average male 4000ml/min  Male marathon runner 5100ml/min

6. Reference(20-29) y(30-39) y(40-50) y German medical staff 46.340.4 36.1 Canadian Sedentary 51.747.442.3 Saudi sedentary 31.5528.8823.9 Compare Maximal oxygen consumption with other population

7. Peak cardiopulmonary function in healthy Saudi males (mean ± SD). (103) Variables Age (years) (20-29)(30-39)(40-50) VO 2 peak (L. min -1 ) 2.22 ±0.322.23 ± 0.291.93± 0.27 VO 2 peak (ml. kg. -1 min -1 ) 31.6±5.928.9± 5.523.9± 3.6 HR peak (bpm)183 ± 8178±8172 ± 8 VE peak (L. min -1 ) 89.6±14.690.2±1582.3 ± 14.2 ** * *

8. effects of exercise intensity on oxygen consumption  during the first 60-120 seconds of effort pulmonary blood flowcardio ‑ dynamic phase  there is an increase in pulmonary blood flow (phase I or the cardio ‑ dynamic phase) muscle extraction of O2 kinetic phase  before a rapid increase in oxygen consumption related to muscle extraction of O2 (phase II or the oxygen uptake kinetic phase)  before reaching steady-state  before reaching steady-state (phase III) if the work load does not result in the accumulation of blood lactate.

9. Relation between oxygen consumption and total pulmonary ventilation at different levels of exercise. oxygen consumption pulmonary ventilation  There is a linear relation between both oxygen consumption (Vo2 Max) and total pulmonary ventilation increase about 20-fold between the resting state and maximal intensity of exercise in the well-trained athlete.

10. Causes of hyperventilation in exercise.  During maximal effort:  Pulmonary ventilation at maximal exercise 100-110L/min  Maximal breathing capacity  Maximal breathing capacity 150-170L/min  maximal breathing capacity is about 50 % greater than the actual pulmonary ventilation during maximal exercise. to giving athletes extra ventilation E.g (1) exercise at high altitudes, (2) exercise under very hot conditions, and (3) abnormalities in the respiratory system.

11. Causes of hyperventilation in exercise cont... neurogenic mechanisms  Respiration is stimulated mainly by neurogenic mechanisms during exercise same nervous signals that are transmitted from the brain  Stimulation results from direct stimulation of the respiratory center by the same nervous signals that are transmitted from the brain to the muscles sensory signals transmitted into the respiratory center  An additional part is believed to result from sensory signals transmitted into the respiratory center from the contracting muscles and moving joints

12. Effects of exercise on arterial PO 2, PCO 2 and H+ ions. (LT) is strongly correlated with ventilatory This increase in is a homeostatic response to deal with the consequences of the excess lactate production to release H+ The H+ ions are buffered by bicarbonate and release CO2 extra CO2  Many studies have since reported that the lactat threshold (LT) is strongly correlated with ventilatory anaerobic threshold (VAT)The term VAT actually refers to the onset of exercise induced hyperventilation during effort. This increase in is a homeostatic response to deal with the consequences of the excess lactate production which can dissociate to release H+ ions from lactic acid into the blood stream. The H+ ions are buffered by bicarbonate and release CO2.This buffering of lactic acid results in extra CO2 production over that produced by aerobic metabolism and increases the arterial CO2 partial pressure (PaCO2). The increase in PaCO2 stimulates excess ventilation that follows on from the lactate threshold.

13. the lactat threshold (LT) is strongly correlated with ventilatory  http://www.youtube.com/watch?v= VBJ97oeyor0

14. Oxygen-Diffusing Capacity of Athletes the rate at which oxygen can diffuse from the pulmonary alveoli into the blood  The oxygen-diffusing capacity is a measure of the rate at which oxygen can diffuse from the pulmonary alveoli into the blood  It is expressed in terms of milliliters of oxygen that will diffuse each minute for each millimeter of mercury difference between alveolar partial pressure of oxygen and pulmonary blood oxygen pressure.

15. Oxygen-Diffusing Capacity of Athletes cont… differences between diffusing capacity at resting and the state of maximal exercise providing greater surface area through which oxygen can diffuse into the pulmonary  differences between diffusing capacity at resting and the state of maximal exercise make blood flow through many of the pulmonary capillaries and providing greater surface area through which oxygen can diffuse into the pulmonary capillary of blood.

16. Oxygen-Diffusing Capacity of Athletes cont… cardiac output remain constant 95% at rest and during maximal effort  The saturation of red blood cells in the pulmonary capillary influenced by cardiac output. And that, might reducing the time for saturation of red blood cells with oxygen In addition, the saturation of blood artery (%SaO2) remain constant 95% at rest and during maximal effort, due to proportional correlation between diffusion of red blood cells and increase exercise intensities. pulmonary diffusion in oxygen uptake can be noticed in the reduction of exercise capacity by exercising at high altitudes patients with COPD such  However, the impact of reduce pulmonary diffusion in oxygen uptake can be noticed in the reduction of exercise capacity by exercising at high altitudes level (3000-5000 m) in which the O2 concentration at atmosphere reduced less than 20.9% in addition, that can be noticed in patients with COPD such as exercise induce by asthma.

17. Thank you Reference book Guyton & Hall: Textbook of Medical Physiology 12E