1. Welcome to the Molecular Medicine course!

2. Registration General information Over-arching goals Roll call Course contents Information about KS library Coffee Course evaluation HT 2010 Study design - research application + presentations Seminar assignment Final examination Molecular Medicine - from bed to bench

3. Course leader: Rachel Fisher 08-517 732 45rachel.fisher@ki.se Deputy course leader: Ewa Ehrenborg 08-517 761 91ewa.ehrenborg@ki.se Teaching assistant: Louisa Cheung 08-517 732 21 louisa.cheung@ki.se Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, L8:02 Course secretary: Anna Wikman Borén Department of Medicine, Unit for Internal Medicine, Karolinska University Hospital, A3:02 08-517 716 33anna.wikman.boren@ki.se Office hours daily 8.00am - 2.00pm

4. Over-arching goals To integrate previously gained knowledge To stimulate team work To analyse, evaluate and interpret raw data To design a study and write a research application To provide “real life” experience

5. Roll call

6. Course set up Lectures usually 9am – 3pm (check venue!) Labs/demonstrations/seminars usually in groups Time scheduled for group work Seminar assignment Presentation of group work (research application) at end of course (trip to Tallinn) Revision time (last timetabled activity 13 th Dec) Final written examination: 22 nd December

7. Course contents (15 hp/ECTS) Specific areas Circulation, Ischemia, Metabolic Syndrome, Diabetes 4 w Gastroenterology1 w Endocrinology1 w Respiration, asthma & allergy 1 w Pathology1 w Clin immunology/Clin chemistry1 w 9 w Assignments etc. Molecular biology lab Seminars Research application Seminar assignment Revision Integrated

8. Course literature Text books from previous courses: physiology, pharmacology, biochemistry, molecular genetics, immunology Articles and links on the web page Lecture summary points (from lecturers)

9. Information about KS library Barbro Wiström

10. Lab “Methods in Molecular Biology” Lectures, demos, labs, exam Research plan Seminar assignment Pathology seminars

11. Labs and Demonstrations Lab: “Methods in Molecular Biology – Theory and Practice” 3/11 (introduction) 15-17/11, 22-24/11, 29/11-1/12 (lab) 6-7/12 (analysis + statistics) 9/12 (discussion + presentations) Angiography demonstration (3/11) Lung/allergy demonstration (9/11) Blood grouping lab (12-13/12)

12. Labs You must bring your own lab coat It is compulsory to have a lab coat to perform the labs If you have lost the lab coat you were given when you started the Biomedicine Programme, you can buy a new one (499kr): http://www.g-ess.se/ Tel: 08-449 85 70 (Stuvsta + Bromma) Some labs and demonstrations will be performed in active research labs - show consideration for those who work there

13. Pathology seminars Pathology integrated into the course 3 seminars:Atherosclerosis(16+18/11) Endocrinology(23+25/11) Gastrointestinal(30/11+2/12) At Huddinge Teacher-led session Self-study Review with teacher

14. Course evaluation HT 2010 Good Research application Lab “Methods in Molecular Biology” Seminar assignment Site visit Course leaders/administration Mixed Clinical emphasis Pathology seminars Lecturers Bad Lack of a course text book Some repetition within lectures Too many lectures Timing of final examination

15. New for HT 2011 Some lectures removed New theme day “Type 2 diabetes, lifestyle and prevention” includes hand-on section Modified data analysis of Lab “Methods in Molecular Biology” Spread work load more evenly over course Final examination before Christmas Presentation of research applications at end of course, including trip to Tallinn

16. Evaluation of the course We rely on your feedback to improve the course Please give constructive feedback Evaluation forms (online) Cinema ticket voucher if all evaluation forms completed + submitted! Course councils –with representatives 28/11 –with whole class 12/1

17. Forms of feedback feedforward assignments  Research application whole-class feedback  Methods in mol biol Research application feedback on assignments & exam Pre-submission guidance and feedback  Research application editing and redrafting  Methods in mol biol reviewing progress with  students Informing about feedback Course councils and evaluations

18. Course language All literature in English Lectures in English All assignments may be written in either English or Swedish

19. Research application Group assignment Choose a specific issue to focus on Design a research project Write a research application Present the project orally Answer questions Team work Realistic exercise

20. Research application: groups and topics Groups 1-6 each split in 2 12 ”subgroups” of 3-4 people Each subgroup allocated a broad topic Detailed project chosen by the subgroup Discussions with and feed back from topic ”mentor”

21. Research application – broad topics Vascular biology (molecular imaging) Transcription factor regulation in inflammation Aneurysm Energy metabolism (endocrinology) Genetics of thrombosis and haemostasis Diabetes and co-morbidities Metabolism and cardiovascular disease Mesenchymal stem cells and bone formation Cell death in metabolism Interactions between lipids and coagulation factors Inflammation in cardiovascular disease Allergy 2 topics/group, 3-4 people/research application

22. Research application topic lottery

23. Seminar assignment Handed out at course start Group work / individual assessment Research based aspects, requires independent work Obtain appropriate information - lectures, discussions, web, articles..… Time scheduled to prepare answer Presentation of assignment in seminar format: Groups 3 + 4Thursday 17 th November Groups 5 + 6Friday 18 th November Groups 1 + 2Thursday 24 th November Grading = pass / fail

24. Time in schedule for Groups 3 + 4 to work with seminar assignment

26. Time in schedule for Groups 5 + 6 to work with seminar assignment

28. Time in schedule for Groups 1 + 2 to work with seminar assignment

30. Examination Final examination: Thursday 22 nd December Grades A-F Questions testing knowledge + understanding

31. Grading of the examination F, Fx, E, D, C, B, A Goal-based assessment Evaluating the level of knowledge obtained not the amount of knowledge F, Fx = fail E = basic pass: identify, describe, list C, D = pass with merit: compare, explain connections, analyse, apply B, A = pass with distinction: theorise, hypothesise, reflect

32. Prestructural F Unistructural Fx Multistructural E Relational C, D Extended abstract B, A One relevant aspect Several relevant independent aspects Integrated into a structure Generalized to new domain

33. To pass the course … The student must obtain a grade of at least E for the written examination (5 hp) The student must also pass –the seminar assignment (3 hp) –the research application (3 hp) –all labs, demonstrations, seminars (4 hp)

34. Replacement assignments When compulsory parts of the course are missed, there are replacement exercises If written, these must be handed in by the last day of the course (13 January 2012) Next opportunity for submission = next course (HT2012)

35. Term 6 Tuesday 1 st November, 2pm Lars-Arne Haldosén Jan-Ingmar Flock Jonas Sundbäck Masters Programme Monday 28 th November, 2pm Jan-Olov Höög Information about …

36. Molecular Medicine: from bed to bench Important clinical contact Translational research Cross-disciplinary “From bench to bed and back again”

37. Please use the web page!