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BIOmem Glucose sensor Une belle histoire…. - Concept -- Clark (1956) - Concept -- Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme.

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Presentation on theme: "BIOmem Glucose sensor Une belle histoire…. - Concept -- Clark (1956) - Concept -- Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme."— Presentation transcript:

1 BIOmem Glucose sensor Une belle histoire…

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4 - Concept -- Clark (1956) - Concept -- Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme electrode -- Lyons and Clark (1962) HISTORY OF BIOSENSORS

5 Oxygen sensor: [O 2 ] current GlucoseGluconic acid OxygenHydrogen Peroxide O 2 H 2 O 2 Glucose Oxidase

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7 - Concept -- Lyons and Clark (1956) - Concept -- Lyons and Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme electrode -- Lyons and Clark (1962) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) HISTORY OF BIOSENSORS

8 Peroxide sensor: [H 2 O 2 ] current GlucoseGluconic acid OxygenHydrogen Peroxide O 2 H 2 O 2 Glucose Oxidase

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10 1975 : YSI 23A Blood Glucose Analyzer First whole blood glucose analyzer (YSI, USA) 1982 : YSI 2300 STAT Plus Glucose & Lactate Analyzer Glucose analyseur commercialisé par YELLOW SPRINGS Instr. Co.

11 - Concept -- Lyons and Clark (1956) - Concept -- Lyons and Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme electrode -- Lyons and Clark (1962) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) - Enzyme Electrode – MediSense Inc. (1987) - Enzyme Electrode – MediSense Inc. (1987) HISTORY OF BIOSENSORS

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13 Mediator (ferrocene)e - current GlucoseGluconic acid OxygenHydrogen Peroxide O 2 H 2 O 2 Glucose Oxidase

14 1983 : Glucose capteur avec médiateur électrochimique GlucoseGluconic acid GOD-FADGOD-FADH 2 FerriciniumFerrocene 1 e-

15 THE MEDISENSE* EXACTECH™ GLUCOSE biocapteur pour le sang *MediSense is now owned by Abbott Since 1996 (867 million $) WalMart ReliOn™ (MediSense ™)

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17 2005 : GlucoWatch G2 (Cygnus Inc., USA) : based on electroosmosis and electrochemical measurement of interstitial fluid Evolution récente : système non invasif

18 GLUCOSE SENSOR Market opportunity -Diabetus Biology -Glucose oxidase Instrumentation -portable Electronics -data processing Chemistry -polymers -electrode materials -mediators

19 Glucose sensors Others THE BIOSENSOR MARKET The growing global problem of diabetes Statistics199520002025 (estimate) People with diabetes (million)135154300 % in developed countries25.223.817.1 Female/male ratio1.181.161.12 Source: World Health Organisation.(Newman & Turner, 2005)

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