2. CONTENT SCIENTIFIC BACKROUND IN THE CZECH REPUBLIC LOCAL STAKEHOLDERS CONGRESS VENUE: PRAGUE CONGRESS CENTRE FINANCIALS ACCOMMODATION IN PRAGUE SOCIAL PROGRAMME WHY PRAGUE, CZECH REPUBLIC? CONCLUSION

4. Jaroslav Heyrovský Nobel Price Winner in Chemistry Antonín Holý Pioneer in the discovery of Virostatics Otto Wichterle Inventor of the soft contact lenses STRONG SCIENTIFIC BACKROUND

5. LOCAL ORGANIZING COMMITTEE President of the congress: Assoc.Prof. Milan Grundmann, M.D., Ph.D. Members at Large: Prof. Stefan Alusik, M. D., Ph.D. Assoc.Prof. Otto Mayer, M. D., Ph.D. Assoc.Prof. Jitka Patockova, M. D., Ph.D. Assoc.Prof. Petr Petr, M. D., Ph.D. Assoc.Prof.Karel Urbanek, M. D., Ph.D. Dr.Hana Brozmanova, Ph.D. Ivana Kacirova, M. D., Ph.D. David Suchy, M. D., Ph.D.

6. THERAPEUTIC DRUG MONITORING, PHENOTYPING AND GENOTYPING – THE BASES OF PERSONALIZED PHARMACOTHERAPY OUR MAIN TOPIC FOR THE 2015 CONFERENCE

7. PROPOSED CHANGES IN THE CURRENT CONFERENCE STRUCTURE In order to reach higher participation of the physicians in clinical practice we propose: Close cooperation with societies of Internal medicine, Cardiology, Hypertension, Pediatrics, Geriatrics, Neurology, Psychiatry, Nephrology, Gynecology etc. Every symposium and section will be introduced by the lecture concerning to pharmacotherapy, followed up TDM lectures (analytics, interpretation and clinical usefulness)

8. Can we do without drugs ? TDM in Drugs of Abuse (testing, monitoring, screening, random testing, reasonable suspicion testing, post accident testing, follow-up testing) with cooperation of police, prisoner duty The application of high resolution mass spectrometry to the screening of drugs and toxicants Is there a future for techniques not based on mass spectrometry for TDM and CT ? Analyses of toxicological events in different medical disciplines (cooperation's with clinicians, toxicologists, clinical pharmacologists and pharmacists) PROPOSED CHANGES IN THE CURRENT CONFERENCE STRUCTURE

9. PROPOSED CHANGES IN THE CURRENT REGISTRATION STRUCTURE To support the increase of the number of participants, we propose following changes in the registration structure : Implement „standalone“ workshops with interdisciplinary themes Selected lectures will be opened also for one-time registration to increase the number of participants from other medical societies Reduced registration fee for students for selected lectures.

10. CZECH SOCIETY OF CLINICAL PHARMACOLOGY 1976 - Section of Clinical Pharmacology of CSECPT 2009 - Czech Society of Clinical Pharmacology (60 members) 2 CPI (Ostrava), 1 CPD (Pilsen), 9 CPU (Prague, Brno, Olomouc, Ceske Budejovice, Hradec Kralove) www.klinfarm.cz Organizers of: 18 National Congresses of TDM 14 National Congresses of Clinical Pharmacology 5 Czech – Slovak Congresses of Clinical Pharmacology 4 Congresses of Czech Society of Hypertension 2 Satellite Symposiums of EACPT (2003, 2005)

11. LOCAL STAKEHOLDERS

12. CZECH-IN LTD. Founded:2002 Business Activity: Congress, Event and Association Management Annually organizes: 8 Congresses and 40 Conferences Nr. of delegates per year: more than 15 000 Employees:28 full time staff, 15 freelance staff Based in:Prague Congress Centre (PCC) Member of:ICCA, MPI, PCB, ISO certified http://www.czech-in.cz/

13. ESHRE 2006 22nd Annual meeting of the European Society of Human Reproduction and Embryology Event with the highest nr. Of participants in 2006 (6540 participants) Event with the largest Exhibition (280 booth) ERA-EDTA 2011 48TH Annual congress of the European renal association The largest event in Prague in 2011 (10600 participants) FEBS 2009 34TH conference of federation of european biochemical societies Event with the highest Nr. of abstracts (1548 abstractS) HPV 2006 23rd International Papillomavirus Conference and Clinical Workshop Event with the highest nr. of sponsors activiteis and sponsored items During the event MAIN INSTITUTIONAL EVENTS ORGANIZED BY C-I

14. LOCAL AUSPICES Prague Convention Bureau www.pragueconvention.cz CzechTourism www.czechtourism.cz City of Prague www.cityofprague.cz Czech Airlines www.csa.cz Prague Congress Centre www.kcp.cz

15. LOCAL AUSPICES Ministry of Health http://www.mzcr.cz/ Czech Conference of Rectors http://crc.muni.cz/ Council of Higher Education Institutions http://www.radavs.cz/

16. Prague Convention Bureau www.pragueconvention.cz CzechTourism www.czechtourism.cz CZECH-IN, Professional Congress Organiser www.czech-in.cz Prague Congress Centre www.kcp.cz LOCAL SUPPORT

17. LOCAL BUSINESS RocheWatersAgilent ChromsystemSiemensAbbott

18. THE PRAGUE CONGRESS CENTRE

19. PRAGUE CONGRESS CENTRE - ESSENTIALS Located within the City Centre Located on the Metro station Up to date AV and Technical Equipment In-house catering company to be known as the best in the Czech Republic Historically connected with such events like NATO Summit, EU Presidency Spacious foyers to hold large exhibitions, unique view on the Old Prague Seat of CZECH-IN

20. LOCATION OF THE PRAGUE CONGRESS CENTRE

21. THE PRAGUE CONGRESS CENTRE MEETS ALL REQUIREMENTS AND MOST FLEXIBLE SOLUTIONS TO HOST THE IATDMCT CONGRESS PRAGUE CONGRESS CENTRE

22. FORUM HALL Hall located on the 2 nd floor Capacity: 1034 persons -Connected to the parallel rooms -Easy access from PCC main etrance

23. FOYERS – EXHIBITION AREA Forum Hall Foyer 2 nd floor Total area: 600 m² netto - Considered also as the catering area - Easy access from Plenary room and breakout rooms - Natural daylight - Panoramic view on Prague

24. Plenary session Parallel session Exhibition+Catering area Posters Office, speakers ready room Registration Cloakroom PCC – GROUND FLOOR

25. PCC – 1 st FLOOR Plenary session Parallel session Exhibition+Catering area+ Posters Speakers ready room Registration Cloakroom

26. PCC – 2 nd FLOOR Plenary/Parallel session Parallel session Exhibition+Catering area+ Posters Speakers ready room Registration Cloakroom

27. Plenary hall FORUM HALL PARTER 1 Day rental Maximum Capacity 650 pax theatre style 170 000 Parallel sessions and other rooms MEETING HALL IV 1 Day rental Maximum Capacity 220 pax theatre style 41 300 MEETING HALL V 1 Day rental Maximum Capacity 220 pax theatre style 41 300 TERRACE 1 1 Day rental Maximum Capacity 160 pax theatre style 31 500 TERRACE 2 1 Day rental Maximum Capacity 120 pax theatre style 26 700 MEETING ROOM 2.1 (office) 1 Day rental Maximum Capacity 50 pax theatre style 11 500 DRESIING ROOM OF CONGRESS HALL 220 1 Day rental Maximum Capacity 50 pax theatre style 10 100 DRESIING ROOM OF CONGRESS HALL 221 1 Day rental Maximum Capacity 40 pax theatre style 8 100 DRESIING ROOM OF CONGRESS HALL 222 1 Day rental Maximum Capacity 40 pax theatre style 8 100 PCC - OVERVIEW Prices are in CZK excl. VAT. for 1 day rental

28. Exhibition + catering + registration FORUM HALL FOYERTotal area 600 sqm netto – Exhibition + catering102 900 CONGRESS HALL FOYER 1BTotal area 418 sqm netto – Exhibition + catering39 200 Prices are in CZK excl. VAT. for 1 day rental PCC - OVERVIEW

29. PCC – LOCATION & TRANSPORT Just two stops by the underground or 10-15 minutes to walk from the downtown City center

30. PCC IN NUMBERS

31. PCC REFERENCES

32. FINANCIALS

33. FINANCIAL STRUCTURE Registration : 157 083,33 EUR excl. VAT ( Early registration fee, 10% students, 550 pax) Sponsorship : 42 517,01 EUR excl. VAT ( already in negotiation with potential sponsors ) Exhibition: 85 034,01 EUR excl. VAT ( 25 stands ) Organisation costs: 35 500 EUR excl. VAT ( 12,8% from the turnover) CONCLUSION The conference profit: 7 700 EUR excl. VAT FINANCIALS

34. Registration fee: Member 350 EUR Non Member390 EUR Young scientific Member180 EUR Young scientific Non Member200 EUR REGISTRATION FEE

35. FINANCIALS BALANCE / 550 PAX IATDMCT 2015 Prague Congress Centre, Czech Republic Rate CZK/Euro:24,50 BALANCE Total (CZK, excl VAT) Total (EUR, excl VAT) % on total (%, excl VAT) COSTS 6 784 800,00 Kč276 930,61 € PRINTED MATERIALS (PROMOTION MATERIALS) 100 250,00 Kč4 091,84 €1,48% GRAPHICS (GRAPHICS TEMPLATES, LOGO) 30 000,00 Kč1 224,49 €0,44% SIGNPOSTING (NAVIGATION SYSTEM) 60 000,00 Kč2 448,98 €0,88% DELEGATE'S SERVICES (REGISTRATION, ABSTRACTS ETC.) 376 000,00 Kč15 346,94 €5,54% STAFF (HOSTESSES, HELPERS) 155 000,00 Kč6 326,53 €2,28% CZECH-IN CONGRESS MANAGEMENT (PRODUCTION TEAM) 420 000,00 Kč17 142,86 €6,19% AGENCY FEE 450 000,00 Kč18 367,35 €6,63% RENTALS (MEETING ROOMS, HALLS AND FOYERS) 1 489 400,00 Kč60 791,84 €21,95% AV AND TECHNICAL EQUIPMENT 771 050,00 Kč31 471,43 €11,36% CATERING (COFFEE BREAKS AND LUNCHES) 1 370 600,00 Kč55 942,86 €20,20% SOCIAL PROGRAM (WELCOME RECEPTION) 265 500,00 Kč10 836,73 €3,91% SPEAKERS AND GUESTS (TRAVEL COSTS, ACCOMMODATION) 297 500,00 Kč12 142,86 €4,38% OTHER SERVICES (BANK COSTS, BAGS AND SUCH) 999 500,00 Kč40 795,92 €14,73% INCOME 6 973 541,67 Kč284 634,35 € REGISTRATION FEE (BASED ON THE EARLY FEE / 550 PAX) 3 848 541,67 Kč157 083,33 €55,19% SPONSORS (ESTIMATE) 1 041 666,67 Kč42 517,01 €14,94% EXHIBITION (25 STANDS) 2 083 333,33 Kč85 034,01 €29,87% BALANCE188 741,67 Kč7 703,74 € CZECH-IN Professional Event ► Congress Organizer

36. FINANCIALS BALANCE / 750 PAX IATDMCT 2015 Prague Congress Centre, Czech Republic Rate CZK/Euro:24,50 BALANCE Total (CZK, excl VAT) Total (EUR, excl VAT) % on total (%, excl VAT) COSTS 7 881 870,00 Kč321 708,98 € PRINTED MATERIALS (PROMOTION MATERIALS) 133 550,00 Kč5 451,02 €1,69% GRAPHICS (GRAPHICS TEMPLATES, LOGO) 30 000,00 Kč1 224,49 €0,38% SIGNPOSTING (NAVIGATION SYSTEM) 60 000,00 Kč2 448,98 €0,76% DELEGATE'S SERVICES (REGISTRATION, ABSTRACTS ETC.) 466 000,00 Kč19 020,41 €5,91% STAFF (HOSTESSES, HELPERS) 155 000,00 Kč6 326,53 €1,97% CZECH-IN CONGRESS MANAGEMENT (PRODUCTION TEAM) 420 000,00 Kč17 142,86 €5,33% AGENCY FEE 450 000,00 Kč18 367,35 €5,71% RENTALS (MEETING ROOMS, HALLS AND FOYERS) 1 676 320,00 Kč68 421,22 €21,27% AV AND TECHNICAL EQUIPMENT 908 700,00 Kč37 089,80 €11,53% CATERING (COFFEE BREAKS AND LUNCHES) 1 858 300,00 Kč75 848,98 €23,58% SOCIAL PROGRAM (WELCOME RECEPTION) 354 000,00 Kč14 448,98 €4,49% SPEAKERS AND GUESTS (TRAVEL COSTS, ACCOMMODATION) 297 500,00 Kč12 142,86 €3,77% OTHER SERVICES (BANK COSTS, BAGS AND SUCH) 1 072 500,00 Kč43 775,51 €13,61% INCOME 8 280 208,33 Kč337 967,69 € REGISTRATION FEE (BASED ON THE EARLY FEE / 750 PAX) 5 155 208,33 Kč210 416,67 €62,26% SPONSORS (ESTIMATE) 1 041 666,67 Kč42 517,01 €12,58% EXHIBITION (25 STANDS) 2 083 333,33 Kč85 034,01 €25,16% BALANCE 398 338,33 Kč16 258,71 € CZECH-IN Professional Event ► Congress Organizer

37. ACCOMMODATION

38. HOTEL Category Hotel Capacity Distance from PCC PRICE for SGL EURO excl. VAT, incl. Breakfast Radisson SAS 5*2112 metro stops200,- Corinthia Towers 5*532Walking distance160,- Holiday Inn 4*251Walking distance140,- Corinthia Panorama 4*4501 metro stop140,- Yasmin 4*1982 metro stops150,- Beranek 3*801 metro stop60,- Otar 3*351 metro stop60,- Oya 3*351 metro stop60,- Ibis Old Town 3*2715 metro stops58,- Ibis Wenceslas Sq. 3*1811 metro stop58,- Chodov Dormitory 2*10006 metro stops, 1 bus stop15,- Prices are indicative only ACCOMMODATION PRICE OVERVIEW

39. HOTELS LOCATION

40. SOCIAL PROGRAMME

41. VENUES Municipal House Up to 1100 persons Žofín Palace Up to 700 persons O2 Arena Up to 2000 persons Industrial Palace Up to 1800 persons

42. TOURS Large variety of tours inside and outside of Prague Prague, Kutná Hora, Karlovy Vary, Český Krumlov, Karlstejn Castle and many others

43. TourPrice excl. VAT (Euro) Karlovy Vary89,- Cesky Krumlov 85,- Grand Tour of Prague 37,- Prague Jewish Quarter 38,- Hradcany and Prague Castle39,- Prague´s famous Characters34,- Prague Boat Trip on the Vltava river48,- Karlstejn Castle48,- Kutna Hora45,- VENUE Price excl. VAT, incl. services (Euro) Municipal House36000,- Zofin Palace21000.- Trade Fair Palace12000,- Zofin Palace20800,- Industrial Palace16400,- Barrandov Studiosfrom 24000,- O2 Arena38000,- SOCIAL PROGRAMME

44. WHY PRAGUE, CZECH REPUBLIC?

45. The Czech Republic is a safe destination with politically and economically stable environment Rich Cultural and Historical Heritage, UNESCO listed Ideal location and easy access - Situated in the very centre of Europe Congresses in Prague usually have higher attendance of 10 – 15 % Extended network of public transportation High quality at competitive prices „Prague hospitality program“ offers public transportation passes for all delegates during congress duration free of charge WHY PRAGUE?

46. Prague is located in the very centre of Europe, with easy access by all means of public transport. At present there are over 100 direct flights from 48 countries around the world. Travel time from most of the European cities is around 1.5 hours, the maximum travel time from e.g. Moscow or Lisbon is 2.5 hours. Prague is suitably connected to the national highway system further interconnected with road nets of all neighboring countries. The city forms the hub of the Czech railway system, with services to all parts of the Czech Republic and abroad. There is also a commuter rail system which serves the Prague metropolitan area. CZECH REPUBLIC – CONNECTION

47. PRAGUE – FLIGHT CONNECTIONS Flights durations FROM / TO PRAGUE Amsterdam705 km1h25 Brussels714 km1h25 Copenhagen643 km1h20 Frankfurt537 km1h10 Helsinki1307 km2h25 Lisbon2241 km3h15 London1035 km2h10 Montreal6197 km8h25 New York6567 km9h10 Oslo1117 km2h00 Paris882 km1h45 Zurich636 km1h35

48. Free circulation of scientists in the Czech Republic is guaranteed No visa for visitors from the EU countries Many non-EU Countries also need no visa : Albania, Andorra, Argentina, Australia, Bolivia, Brazil, Bulgaria, Canada, Columbia, Chile, Croatia, Dominican Republic, Ecuador, Guatemala, Honduras, Hongkong, Israel, Japan, South Africa, Korea, Costa Rica, Macao, Malaysia, Mexico, Monaco, Nicaragua, New Zealand, Panama, Paraguay, Peru, Romania, Salvador, San Marino, Singapore, Serbia, Montenegro, Brunei, Switzerland, Turkey, Uruguay, USA, Vatican, Venezuela Citizens from the rest of world need visa, but generally the procedure is quick and very simple. For more information visit web www.mzv.cz IMMIGRATION CONTROL

49. Czech Republic is situated in the temperate climate zone, described by pleasantly warm summers Average low to high temperatures range between 12-14 ºC to 22-24 ºC Precipitation of 65-73 mm, 71-73 % of air humidity Typically 230-250 sunshine hours per month CLIMATE

50. The Czech currency is called the Czech Crown (CZK). Exchange offices are located all around the city centre (exchange offices, banks, post offices). At present 1 Euro = 24.5 CZK, 1 USD = 18.5 CZK,1 GPB = 28 CZK, 1 AUD = 18 CZK All types of credit cards (Visa, MasterCard, American Express) are generally accepted Many hotels and restaurants accept Euro as well. CURRENCY

51. EXCELLENT TRANSPORTATION NETWORK Congress Centre Located at the Metro station (Vysehrad), 2 stations from the downtown Adult ticket for 1 EUR / Congress delegates for free for the congress duration

52. Prague (Praha) - capital and the largest city in the Czech Republic, with about 1.3 million people Situated on the river Vltava in central Europe Political, cultural and economic centre of the state Home to a number of famous cultural attractions Since 1992 on the UNESCO list of World Heritage Sites One of the most popular tourist destinations; over 4 millions visitors annually - the 6th most visited in Europe ABOUT PRAGUE

53. Prague contains one of the world’s most pristine and varied collections of architecture, ranging from Art Nouveau to Baroque, Renaissance, Gothic and Neo-Classical. Hundreds of concert halls, galleries, cinemas and music clubs. Each year Prague hosts a number of famous international music festivals as well as hundreds of vernissages and fashion shows Prague can be enjoyed not only for its museums and cultural sites but also for famous Czech beer and hearty cuisine. ABOUT PRAGUE

54. PRAGUE ON PICTURES

56. CONCLUSION

57. The Czech Republic has a strong knowledge-based economy The committed Team is in place with identified responsibilities Our candidacy is supported by leading officials and stakeholders Dynamic practices will be applied to exceed the planned economic outcome Prague has a proven record of successfully organized large international events IATDMCT conference has never taken place in Prague Prague selection will further stimulate - Implementation of appropriate legislation - Positive public/institutional awareness - Participation from the Central & Eastern European Region CONCLUSION

58. WE ARE LOOKING FORWARD TO WELCOMING YOU TO PRAGUE IN 2015!